Sentences with phrase «immune mechanisms of»

Dr. Kim is particularly interested in glutamate homeostasis and the interplay between neural and immune mechanisms of drug dependence and relapse.

OBJECTIVE: To elucidate potential immune mechanisms of treatment - induced ME.

Not exact matches

Tecentriq belongs to a class of drugs called PD - 1 inhibitors, which help the immune system to fight cancer by blocking a mechanism that tumors use to evade attack.

if you're referring to classical Christianity, God created man immune to such destruction yet man then invited entropy into the system; so then God went all out in order to provide a mechanism of forgiveness so that even as beings of discord we could be compatible with eternity and preserved.

The immune system is actually an astonishing array of struc - tures and mechanisms de - signed to defend us from a wide variety of agents, in - cluding bacteria and viruses.

In addition, Red Star Nutritional Yeast contains other beneficial components, such as beta - 1,3 glucan and mannan, complex carbohydrates known to improve the immune response and help maintain cholesterol levels that are already within a healthy range; trehalose, a disaccharide that helps maintain the health of brain cells; and glutathione, an antioxidant that plays an important role in cellular defense mechanisms.

Through a variety of mechanisms, a healthy gut has been shown to improve immune function, fight certain forms of cancer, prevent diabetes, increase fat metabolism and encourage a healthy body weight.

And yet the intricacies of that science — the precise mechanisms through which adrenal glands release glucocorticoids and immune cells send out cytokines — don't tell us much about how best to help children in trouble.

«It appears the immune system becomes educated when there is an overlap of solids and breast milk because the milk promotes tolerogenic mechanisms against the solids.

The authors suggest several biological mechanisms of breast milk may explain their results, including that breast milk contains many immunologically active components and anti-inflammatory defense mechanisms that influence the development of an infant's immune system.

One mechanism for food reaction = > oversupply link I've heard is: milk production is connected to white blood cell and mucous production, which are both heavily involved with the immune system and, therefore, our systems of inflammation.

Breast milk contains many immunologically active components and multifactorial anti-inflammatory defense mechanisms that influence the development of the immune system of the breastfed infant.

There are a variety of mechanisms of immune resistance that operate in the tumor.

The advance, reported in Proceedings of the National Academy of Sciences (PNAS) journal, for the first time allows scientists to analyze how normal gut microbes and pathogenic bacteria contribute to immune responses, and to investigate IBD mechanisms in a controlled model that recapitulates human intestinal physiology.

What we're hoping, therefore, is that the new mechanisms we've discovered will help in the development of more targeted drugs, where existing immune - modulating drugs can also be of interest.»

Meanwhile, Van den Eynde and his team are already hard at work looking for the other novel mechanisms of immune suppression in their model.

To understand the mechanism of how Neu5Gc affects the human immune system, researchers analyzed various cells of the immune system that play a role during an inflammatory reaction.

Commenting on the study for ESMO, Dr Olivier Michielin, head of Personalised Analytical Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, said: «Omaveloxolone's novel mechanism of action is to block MDSCs, cells known to suppress the immune response.

The work was on the role of interleukin - 1 in the pathology of graft - versus - host disease (GVHD), the mechanism by which the new immune system, which a patient receives as a bone marrow transplant, attacks the patient's body following the transplantation.

According to Kemble, many of today's vaccines were created by relying on the natural immune response mechanisms.

Publishing online this week in Cell Host & Microbe, researchers at Johns Hopkins report the discovery of a key underlying immune mechanism that explains why to how our skin becomes inflamed from conditions such as atopic dermatitis, more commonly known as eczema.

«This discovery demonstrates the effect the gut microbiome has on the immune system and unearths a novel mechanism via which changes in the gut microbiome can increase the risk of autoimmune disorders.

Only viruses that have mutated escape mechanisms from immune pressures are able to survive, but the mutations come at the cost of other aspects of viral fitness, perhaps inhibiting entry into cells or integration into cell DNA.

The molecule regulates genes that suppress immune surveillance mechanisms, including the production of cells that inhibit the immune response.

In addition to formulating diagnostic strategies for cancer immunotherapy agents, her team is focused on developing a deep understanding of tumor immune biology as well as mechanisms associated with immune response and immune escape in cancer patients, with the intent of generating rational strategies for the creation of combination therapies.

In a study published in the journal Science, an international collaboration of investigators from Dana - Farber, Harvard Medical School, Boston Children's Hospital, and the University of Strasbourg uncovered a mechanism that allows key immune system cells to keep a steady rein on their more belligerent brother cells, thereby protecting normal, healthy tissue from assault.

Scientist at the University of Copenhagen and Skejby Hospital will continue their work on how bacteria might affect the balance between the immune defence mechanism and the disease.

Professor Nutt said increasing our knowledge of the mechanisms that controlled the immune response was vital for understanding how immune and inflammatory diseases arise and, ultimately, developing more effective treatments.

«We believe that small subsets of metastatic tumor cells have the ability to adopt the mechanisms used by immune cells to exit the blood vessels into the lungs, the bone marrow, the brain, and other organs.

«Our study reveals a new mechanism that could be harnessed for biological therapies for lupus and other autoimmune diseases, where the immune system mistakenly targets the body's own cells,» says senior study author Boris Reizis, PhD, professor of Pathology and Medicine at NYU Langone.

The TSRI scientists discovered the fundamental mechanism of the S1PR1 receptor, developed the chemical tools to synthesize both agonists and antagonists of the receptor, discovered the role of the receptor in the immune system's «cytokine storm» in pandemic influenza, and investigated the role of the receptor in type 1 diabetes.

The underlying mechanism involves the activation of the immune system, resulting in local inflammation and proliferation of skin cells.

«It suggests there's a common mechanism in both species for susceptibility to tumor progression that may involve subversion of the host immune response.

This suggests, the researchers say, that because previous generations of Yanomami had never been exposed to TB, their immune systems had not evolved a mechanism for mounting an immune response to it.

«Like zebrafish, we have this rich source of gut microbes that have figured out how to coexist with us and soothe the immune system,» she says, adding that «there is enormous potential to harness those mechanisms» to address ailments such as inflammatory bowel disease and other chronic inflammation.

«The practice of the Wim Hof Method may lead to tonic changes in autonomous brain mechanisms, a speculation that has implications for managing medical conditions ranging from diseases of the immune system to more intriguingly psychiatric conditions such as mood and anxiety disorders,» said Diwadkar, professor of psychiatry and behavioral neurosciences.

Based on a defense mechanism in the immune system of bacteria that hunts and destroys invading viruses, CRISPR can locate and replace specific genes.

The Leuven - based VIB researchers have revealed a mechanism that explains why the anti-tumor activity of specific immune cells called macrophages is suppressed during tumor growth.

The authors said that this result suggests that the reason bacterial numbers are so high in these mice, and, by extension, human LAD patients, is not because of a defect in the immune system's surveillance mechanism but because of the inflammation caused by the immune system's abnormal response to normal levels of bacteria in the gums.

A group of researchers at Immunology Frontier Research Center (IFReC), Osaka University and RIKEN Center for Integrative Medical Sciences jointly clarified the mechanism for inducing germinal - center B cells» differentiation into memory B cells, immune cells that remember antigens, at the molecular level.

HIV also has developed sophisticated mechanisms to dodge immune attack, shrouding its surface protein in sugars to hide vulnerable sites from antibodies and producing proteins that thwart production of other immune warriors.

«Mechanism for inducing memory B cell differentiation elucidated: Efficient induction of immune cells that remember antigens will lead to the development of new vaccines.»

Researchers targeting colorectal cancer stem cells — the root cause of disease, resistance to treatment and relapse — have discovered a mechanism to mimic a virus and potentially trigger an immune response to fight the cancer like an infection.

«We have been able to isolate the mechanisms that prevent the immune systems of children with an IFIH mutation from successfully combating the viral infection.»

«In addition, the results of this study provide new mechanisms for how abnormal pigmentation associated with some melanocytic nevi and melanomas might arise as a result of immune responses to the growths.»

The drug's mechanism of action was entirely new: Instead of attacking cancer cells (like chemo), or indiscriminately revving up the immune system (like IL - 2), ipilimumab blocked a single receptor on one type of immune cell.

Just as flu season swings into full gear, researchers from the University of Colorado Boulder and University of Texas at Austin have uncovered a previously unknown mechanism by which the human immune system tries to battle the influenza A virus.

Future studies are needed to better define the molecular mechanism behind TREML4 - induced amplification of TLR7 signaling and to clarify beneficial reactions controlled by TREML4 — for example, the immune response to influenza virus, which the current study found was inhibited by TREML4 deficiency.

In laboratory studies, daratumumab caused the targeted killing of CD38 - carrying tumor cells by several distinct and potent mechanisms, including some that involve the immune system.

The ability of these children to maintain an intact immune system in the face of ongoing viral replication and in the absence of antiretroviral therapy can provide us with new insights into hitherto unknown defense mechanisms, which could eventually benefit other HIV patients,» says Professor Oliver T. Keppler, Chair of Virology at the Pettenkofer Institute, and former head of the German Reference Center for Retroviruses in Frankfurt am Main.