Sentences with phrase «immune molecule called»

Compared to skinnies, muscular men also tended to produce fewer infection - fighting white blood cells and less of an important immune molecule called C - reactive protein, which helps destroy pathogens.

The protein senses a potent immune molecule called tumour necrosis factor (TNF) that destroys cancerous cells but that is also implicated in autoimmune disease.

The study pinpoints an immune molecule called interferon gamma as the key to this link.

But rather than delivering the entire gene for the clotting - factor proteins to cells, as most gene therapies do, the researchers used the viruses to engineer immune - regulating B cells to express a fragment of the clotting factor fused to an immune molecule called an immunoglobulin.

Not exact matches

The reason for this is that breastmilk has immune molecules, called antibodies.

The molecule in question, known as beta - 2 microglobulin, or B2M, is a component of a larger molecule called MHC I (major histocompatibility complex class I), which plays a major role in the adaptive immune system.

The researchers looked for 200 types of immune - signaling molecules called cytokines and identified 64 that were different, usually more abundant, in the eyes affected by NIV.

For decades, researchers have suspected that when the immune system molecule CD1a comes in contact with the plants» oily resin, called urushiol, it triggers inflammation.

The immune system depends on molecules called T cell receptors on the surface of T cells to recognize and respond to foreign antigens from virus - infected cells, tumors and other threats.

If either is present, it will bind to a specific molecular brush linked to immune molecules, called antibodies, which affix to antigen 85b and alpha - crystallin but reject all other proteins.

In this study, the SIgN team discovered for the first time that the integrity of p53 affects the production of a special cell surface protein called Major Histocompatibility Complex (MHC) class I. MHC class I molecules on the cancer cell surface serve as targets for the immune system.

One key gene encodes the making of a receptor called TREM2, a docking site for molecules on the surface of microglia and other innate immune cells.

One approach uses an antibody called ipilimumab, which may block a molecule that inhibits the immune system.

Yet until she proved otherwise, few scientists thought MHCI or other so - called «immune molecules» were even present in a normally functioning brain.

Assembling mRNA using pseudouridine, a nucleoside variant that occurs naturally in the body, greatly reduced the tendency of immune sentinels called dendritic cells to shoot out inflammatory molecules in response, they reported in 2005.

In their report published in Science Immunology they describe how expression of a specific molecule — complement C5a — is required to cause the immune cells called neutrophils to adhere to joint surfaces and migrate into the joint, a process known to set off the inflammatory cascade.

The virus uses a shield of sugar molecules, called glycans, to hide from the immune system and block antibodies from attacking it.

Immune messenger molecules called cytokines and certain types of immune cells race to the bite site, making it inhospitable for the parasite.

Current thinking regarding type III hypersensitivity is that immune cells within tissues sense the presence of these immune complexes (ICs) through specific receptor molecules and release inflammatory factors called cytokines that activate the endothelial cells lining adjacent blood vessels to promote the recruitment of neutrophils.

Gram - negative bacteria produce molecules called lipopolysaccharides (LPS) that are potent activators of innate immune signaling.

Some of the killer cells lose CXCR5 upon stimulation, but adding an immune regulatory molecule called TGF - beta can boost the CXCR5 levels.

Zitvogel's team found that a specific immune signaling molecule, or cytokine, called IL12 that is released in response to A. muciniphila may help rally the T cells.

But mounting evidence implicates the immune system in the overproduction of cell - signalling molecules called cytokines, which stimulate skin cells called keratinocytes to express genes that maintain an inflammatory microenvironment.

In both cases, the immune cells produced fewer inflammatory molecules, particularly one called interleukin 17, or IL - 17, which is strongly associated with MS and very harmful to nerve cells and their insulating covers.

A new class of drugs called immune checkpoint inhibitors block molecules on T cells that shut down immune response, freeing the immune system to attack tumors.

These molecules function by shuttling broken - down proteins called peptides from inside the cell to the surface, where other immune cells inspect them to see whether they are invaders.

Jules Hoffmann of the University of Strasbourg in France first identified a key molecule, called Toll, involved in the innate immune response in fruit flies.

However, this re-activation is blocked in most latently - infected cells by cellular molecules called immune check - points.

They have detected, for example, revved up signaling molecules involved in inflammation, such as tumor necrosis factor α (TNFα) and other cytokines; skewed populations of natural killer cells and other immune cells; imbalances in the protein - destroying enzymes called proteases; and a shortening of the telomeres, the «end caps» on chromosomes, which indicates prematurely aged cells.

But some bacteria have evolved a counter strategy — injecting special proteins that suppress the plant's immune response by adding small, disabling chemical tags called acetyl groups to immune molecules.

The researchers modified a type of human immune cell — called T lymphocytes, or T cells — to target a molecule called CS1, which is found on more than 95 percent of myeloma cells, and to kill the cells.

The auto - reactive B cells produced autoantibodies that mistakenly targeted proteins within their own body, in particular targeting immune inflammatory molecules called interferons and interleukins.

The researchers went on to identify the immune networks underlying IL - 33's harmful effects and discovered that this molecule activates immune cells called type 2 innate lymphoid cells (ILC2), which had never before been linked to liver disease.

Humans respond to cold in two ways: we shiver to produce a quick burst of heat, and as Ajay Chawla at the University of California, San Francisco, recently discovered, immune signals get sent to molecules called macrophages.

After looking at lung samples from 75 young and middle - aged adult victims of the 2009 pandemic, they found an uncanny amount of a protein called C4d, a molecule that normally binds to antibodies to form virus - fighting immune complexes.

Additionally, immune cells express a molecule called CTLA - 4 that inhibits their activation.

He and his colleagues take one immune regulatory molecule, GM - CSF, and stick it onto others, creating a series of potent immune stimulants he calls «fusokines.»

FcRn bears an intriguing structural resemblance to molecules called major histocompatibility complex (MHC) proteins, which function in the vertebrate adaptive immune response by presenting antigenic peptides to T cells.

The molecule, called microRNA 29b, would be ineffective if delivered by injection alone, as it quickly becomes degraded in the bloodstream or picked up and removed by immune cells.

By binding to and blocking certain molecules on T cells, in this case a molecule called PD - 1, pembrolizumab «takes the brakes off» the immune response, allowing a more powerful response to cancer.

In models lacking NLRX1, innate immune cells called macrophages produce higher levels of IL - 6, a signaling molecule that has a central role in colorectal cancer development.

The target of «atezo» is a molecule called PD - L1, which some cancer cells make to try to avoid being killed by the immune system.

He will now investigate a set of molecules called TLR agonists that act through receptors on the surfaces of innate immune cells to set off a chain reaction of molecular signaling and activation within the immune system, which includes activation of latently infected CD4 cells.

Besides keeping microglia at bay, less PLSCR1 resulted in reduced production of inflammatory molecules called cytokines, whose typical role is to recruit more immune cells to the fight.

We have also discovered an adapter molecule called Act1 that has an important role in regulating autoimmunity through its impact on both T - and B - cell - mediated immune responses.

Under normal conditions, so - called checkpoint inhibitor molecules rein in the immune system to ensure that it does not attack the body's own cells, tissues and organs.

The new work focuses on the regulation of immune response by two forms of the signaling molecule IL - 8, as well as IL - 8's interaction with cell - surface molecules called glycosaminoglycans (or GAGs for short).

Most famous is an antibody that targets a molecule on immune cells called PD - 1.

Through his work with large patient groups, he has managed to show that narcolepsy is closely genetically linked to so - called HLA molecules, which play a key part in the immune system by presenting foreign substances to immune cells.

Ozone stimulates the white blood cells to produce immune - related messenger molecules called cytokines.