Sentences with phrase «immune proteins called»

Inflammation creates immune proteins called cytokines.

«When you sleep, your body releases immune proteins called cytokines, which help fight infections and control the body's response to stress,» Dr. Phillips says.

BMS's Opdivo is the second FDA - approved checkpoint inhibitor targeted at an immune protein called PD - 1.

Not exact matches

The treatment is a type of so - called CAR T - cell therapy — taking a patient's own immune cells, called T cells, genetically manipulating them to attack specific proteins on cancer, and infusing them back into the patient.

Findings of the research, published April 22 in the journal Mucosal Immunology, reveal that a substance found in animal and human breast milk called epidermal growth factor, or EGF, blocks the activation of a protein responsible for unlocking the damaging immune cascade that culminates in NEC, a disease marked by the swift and irreversible death of intestinal tissue that remains one of the most - challenging - to - treat conditions.

Breast milk colitis, also called food protein — induced proctocolitis or cow's - milk protein allergy, is a poorly characterized immune reaction to a breast milk food protein (mainly milk proteins) and is the most common food allergy under 2 years of age (21).

A decade ago a drug based on an internal protein of the flu virus, called NP (for nucleoprotein), set the immune system's killer T cells into action, but it only partially protected mice from the flu.

Rothenburg; microbiology doctoral students Chen Peng, China, and Sherry Haller, Topeka; and collaborators from the University of Florida, recently published a study in the Proceedings of the National Academy of Sciences of the United States of America about the function of an immune - regulating protein from myxoma virus, called M156.

Further study revealed that these so - called immune proteins are actually present on the surface of certain nerve cells, but that they functioned differently in the brain than they did in the rest of the body; rather than scouting for germs, they influenced signals sent between neurons.

Four small proteins that stimulate inflammation (called cytokines) were found to work in tandem to trigger inflammatory immune responses that damage and irritate the bowel.

If either is present, it will bind to a specific molecular brush linked to immune molecules, called antibodies, which affix to antigen 85b and alpha - crystallin but reject all other proteins.

In this study, the SIgN team discovered for the first time that the integrity of p53 affects the production of a special cell surface protein called Major Histocompatibility Complex (MHC) class I. MHC class I molecules on the cancer cell surface serve as targets for the immune system.

«We found that a protein expressed by gut bacteria called Bacteroides works to prevent IBD by rapidly recruiting white blood cells to kill a cell of the immune system that is responsible for orchestrating IBD,» says McCoy.

Infectious organisms trip specialized immune cells in the body and cause them to pump out proteins called cytokines, which produce inflammation and other hallmarks of infection, such as chills and fever.

The system, says Brahmer, provides a kind of «handshake» or connection between receptors on immune cells, called PD - 1, and their sister - proteins on tumor cells, called PD - L1.

The gene encodes a protein called PD - 1 that normally acts as a check on the cell's capacity to launch an immune response, to prevent it from attacking healthy cells.

The explanation seems to lie in a protein called SOCS3, which stops immune cells working.

Allison's seminal work focuses on a protein called CTLA - 4, which reins in T - cell activation in the immune system.

On the one hand, the treatment of rats after a stroke involves specific immune therapy, where so - called Nogo proteins are blocked with antibodies.

Both tasocitinib and Incyte's drug, INCB028050, target Janus kinases, which mediate signaling by immune - system proteins called cytokines.

The speaker woefully described his difficulties determining the structure of an immune system protein called calcineurin: Do what he might, one very large region of the protein simply refused to come into focus.

After almost a decade of effort, crystallographers have achieved a major goal in AIDS research: They have determined the detailed structure of the protein HIV uses to infect immune cells called T lymphocytes.

An animal's immune system detects foreign cells by scanning for proteins, called antigens, that stick out from the surface of each cell.

But when PD - 1 binds to proteins called PD - L1 and PD - L2 on the surface of certain cancer cells, the T cells essentially become paralyzed: the immune attack on cancer is called off.

The patients received biweekly infusions of nivolumab, which is an antibody that blocks a protein called PD - 1 on the surface of immune system T cells.

Findings from a study in animals appear to demonstrate that temporarily blocking a type of protein, called type I interferon, can restore immune function and speed up viral suppression during treatment with anti-viral drugs for people with chronic infection of the virus that causes AIDS.

In findings they call counterintuitive, a team of UCLA - led researchers suggests that blocking a protein, which is crucial to initiating the immune response against viral infections, may actually help combat HIV.

Further experiments suggested that the production of high levels of cell wall - associated GAG makes A. fumigatus more resistant than A. nidulans to neutrophil killing by neutrophil extracellular traps, or NETs (NETs are are networks of extracellular fibers, composed of DNA and proteins secreted by immune cells called neutrophils, that bind and trap various pathogens).

The paper focuses on two key molecular players in the story of influenza infection: a human protein called TRIM25, which was recently discovered to play an important role in the human immune response to flu infection; and a protein called NS1 present in all strains of the influenza A virus and shown to bind TRIM25 to keep it from doing its job.

The study included 124 newly diagnosed patients at 25 clinical trial sites in the U.S. Two - thirds of the patients were treated with ICT - 107, an experimental vaccine based on immune system cells called dendritic cells that were exposed to six synthetic proteins, or antigens, known to be involved in GBM development.

But rather than delivering the entire gene for the clotting - factor proteins to cells, as most gene therapies do, the researchers used the viruses to engineer immune - regulating B cells to express a fragment of the clotting factor fused to an immune molecule called an immunoglobulin.

BCL - 2 is a so - called «pro-survival» protein that makes normal immune cells survive for extended periods.

The immune system recognizes transplanted organs as foreign tissue by telltale proteins, called the major histocompatibility complex (MHC), that coat cell surfaces.

Other vaccines in trials target the blood - cell stage, and contain a parasite protein called AMA - 1, meant to prime the body's immune system to attack it.

Because all the itchy mice had a defective version of the E3 ligase, Copeland suspects that their ubiquitin systems fail to tag immune - related defense proteins or foreign substances called antigens for disposal — both of which then might pile up and attract too many helper macrophages to the scene, wreaking havoc with the immune response.

To do this, they vaccinated mice with a combination of two of the T. cruzi proteins (called TcG2 and TcG4), which they had shown to be the most potent in provoking both an antibody and a T - cell immune response.

In EAE, as with MS, immune cells attack a nerve cell protein called myelin, causing symptoms ranging from impaired vision to severe motor dysfunction and even death.

In clinical trials already underway, for example, researchers have used an older gene - editing technique, enzymes call zinc finger nucleases, in immune cells to deactivate the gene for CCR5, a surface protein that HIV latches onto in order to infect cells.

As for the underlying mechanism, there's evidence that a bacterial protein called endotoxin is important for damping down overactive immune systems.

IL - 17 attracted other immune cells called neutrophils — the most abundant type of white blood cell — to the conjunctiva and induced the release of anti-microbial proteins into the tears.

For example, they produce proteins called cytokines that tell infection - fighting immune cells to back off and recruit «suppressor» cells directly from the bone marrow that help cancel the immune attack.

In its normal form, caspase - 12 curtails the production of regulatory proteins called cytokines, which help mount an immune response against bacterial infection.

There also were increased levels of proteins called cytokines that signal the immune system to ramp up.

Significantly, J&J's latest vaccine uses so - called mosaic technology to combine immune - stimulating proteins from different HIV strains, representing different types of virus from around the world, which should produce a «global» vaccine.

Previous studies in the lab showed that once HCMV is inside the cell, it quickly becomes latent by entering the cell's nucleus and co-opting a cellular protein called Daxx — part of the intrinsic immune system — to shut down its own replication, the process of reproducing its genetic material to make more copies of itself.

IFNL4 is a member of the family of proteins called interferons (named after their ability to interfere with viruses), which are an essential part of our immune defence against viral infections.

The protein senses a potent immune molecule called tumour necrosis factor (TNF) that destroys cancerous cells but that is also implicated in autoimmune disease.

MYSM1 is an enzyme in the body's immune system that turns genes on and off by modifying proteins called histones embedded in DNA.

These molecules function by shuttling broken - down proteins called peptides from inside the cell to the surface, where other immune cells inspect them to see whether they are invaders.

Compared to skinnies, muscular men also tended to produce fewer infection - fighting white blood cells and less of an important immune molecule called C - reactive protein, which helps destroy pathogens.