Many are now literally feeling the effects of such macronutrient skew either due to gluten sensitivity (or it could be due to another grain protein; we now realize that immunologic
reactivity in celiac disease may not be limited to wheat gluten, but can involve certain nongluten proteins,
too, see Nongluten wheat proteins triggered
immune response in celiac patients), fructose malabsorption, or some other food intolerance / sensitivity).