Sentences with phrase «immune receptor on»

The gene codes for an immune receptor on red blood cells; lack of that receptor prevents infection by Plasmodium vivax, a species of the malaria parasite.

When the researchers added a little of this bacterial byproduct to the mix, Fel d 1 activated a specific immune receptor on cells, called Toll - like receptor 4 (TLR4).

Not exact matches

A transformative cancer therapy based on modified immune cells has lured doctors, companies, and patients alike, but many are hitting a frustrating roadblock: generating enough of these chimeric antigen receptor (CAR)- T cells to meet surging demand.

The immune system depends on molecules called T cell receptors on the surface of T cells to recognize and respond to foreign antigens from virus - infected cells, tumors and other threats.

These are receptors on immune cells, which control for example effector T - cells by dampening their activation if damage to healthy cells is imminent.

They identified five receptors closely related to a class of receptor already known to help immune cells hone in on pathogens and inflammation.

This drug (vedolizumab) blocks a specific adhesion molecule on the surface of the T - cell and thereby inhibits immune cells from binding themselves to receptors present in the intestine, preventing the T - cells from penetrating the blood vessels in the intestinal tissue.

A 2 - year fellowship from the Human Science Frontier Program financed a postdoc at Yale University School of Medicine on the role of so - called «toll - like receptors» in immune responses.

One key gene encodes the making of a receptor called TREM2, a docking site for molecules on the surface of microglia and other innate immune cells.

«What we think happens is that the bacteria activate immune cells, which release chemicals called cytokines that then act on receptors on the sensory nerves to increase their activity,» he says.

What they discovered was that an inflammatory factor known as TGF - beta (transforming growth factor - beta) can give cancer cells properties of immune cells by supplying the surface of the cancer cell with a receptor that normally only exists on the white blood cells that travel through the lymphatic system.

The system, says Brahmer, provides a kind of «handshake» or connection between receptors on immune cells, called PD - 1, and their sister - proteins on tumor cells, called PD - L1.

Dectin - 1 previously has been studied as a receptor that recognizes structures on fungi and other microbes and triggers immune responses to them.

The drug blocks CTLA - 4, a protein receptor on the surface of T - cells that serves as a molecular stop sign, preventing the immune system from going into overdrive.

THC activated two types of cannabinoid receptor on immune cells, called CB1 and CB2.

In this study, the researchers found that a specific population of immune cells called macrophages have the ability to secrete or produce a protective or healing factor known as Interleukin - 10 (IL - 10), which can interact with receptors on intestinal epithelial cells to promote wound healing.

On encountering the TB bacillus, receptors on immune - system scavenger cells known as macrophages stimulate the conversion of circulating vitamin D to its active form, which produces a peptide that destroys the bacilluOn encountering the TB bacillus, receptors on immune - system scavenger cells known as macrophages stimulate the conversion of circulating vitamin D to its active form, which produces a peptide that destroys the bacilluon immune - system scavenger cells known as macrophages stimulate the conversion of circulating vitamin D to its active form, which produces a peptide that destroys the bacillus.

Prof. Mandelboim and his research collaborators found that the NKp46 receptor present on Natural Killer or NK cells (an essential part of the immune system) play a critical role in the development of the disease in mice.

Antril, which is classified as an interleukin - 1 receptor antagonist, occupies the site on cells lining blood vessels where interleukin - 1 docks before it triggers an immune response.

The drug's mechanism of action was entirely new: Instead of attacking cancer cells (like chemo), or indiscriminately revving up the immune system (like IL - 2), ipilimumab blocked a single receptor on one type of immune cell.

TLR7 is one of a family of receptors present on innate immune cells like macrophages that have been linked to chronic inflammation and autoimmunity.

«The strategy of using peptides that mimic regions of a human immune receptor, to put the brakes on the excessive inflammatory response triggered by superantigen toxins, is a host - oriented strategy that is broadly effective against the diverse family of superantigens,» said Prof. Raymond Kaempfer.

Newly - discovered mechanism of action of the bacterial superantigen toxins: Superantigens bind to both B7 - 2 and CD28, the major costimulatory receptors expressed on human immune cells.

Anti-CD40 drugs (in this trial, CP - 870,893) antagonize the CD40 receptor, and effectively «push the gas» on the immune system to make it work harder.

To curb attacks on our own tissues, immune cells carry receptors that dial down their activity.

PD - 1 (programmed cell death protein 1) is a receptor on the surface of T cells (the white blood cells that are part of the immune system), while PD - L1 (programmed death - ligand 1) is a molecule that binds to PD - 1 and is often over-expressed on the surface of cancer cells, enabling them to evade the immune system and allow cancer to grow and spread.

Organ transplantation is a challenge, requiring immunosuppressive drugs and careful matching of donor and recipient for human leukocyte antigen markers, receptors on immune cells that recognize foreign proteins.

LPA in turn acts on lymphocytes via a specific receptor (LPA2), enabling them to move around efficiently through the narrow spaces in lymph nodes, which are normally jammed with immune cells and stromal cells.

The researchers are now looking at how ICOS signals can be altered to diminish autoimmune disorders and augmented for more effective vaccine development, and are beginning research on how ICOS signaling may benefit Chimeric Antigen Receptor - T cell (CAR - T) therapies, which involves engineering of patient's own immune cells to recognize and attack their cancers.

New findings published in the journal Nature Chemical Biology by UNC School of Medicine scientists show that MRGRPX2, a receptor protein on the surface of mast cells, can trigger the immune system response that leads to itching associated with some opioids.

The ccr5 receptor, a protein found on the surface of cd4 T - cell lymphocytes in the immune system (try saying that quickly), may hold the key to ending the aids pandemic (see «The End of AIDS»).

Receptors on T - cells recognize antigens, or pieces of other cells that trigger an immune response, particularly antibodies.

IL - 6 is a cytokine, a signal molecule that is produced and secreted both by immune cells and by tumor cells and binds specifically to a receptor (IL - 6R) that is found on the surfaces of many cell types.

The Johns Hopkins team tested ImmunoMap's ability to correlate immune responses on receptor sequencing data from T - cells in the tumors of 34 patients with cancer enrolled in a nationwide clinical trial of the immunotherapy drug nivolumab.

«This technique could be applied to other cell types of the immune system — anywhere the receptors on the membrane are renewed often,» says Griessinger.

To test the role of innate immune response in the mouse model of ALS, the researchers focused on Toll - like receptors (TLR), which are important sensors for innate immunity.

The other end, known as the constant region, binds to receptors on the surface of cells that can direct the immune system to respond in a variety of ways, all in the hopes of eliminating the target on the variable end of the antibody.

The drug tested is an antibody that blocks a receptor called PD - 1 on the surface of the immune system's T cells.

These antibody drugs block receptors on T cells that tumors use to hide from the immune system.

The studies, conducted separately on the East and West coasts of the United States, attempt to make the immune system resistant to HIV by crippling a receptor, known as CCR5, on T cells that the virus uses during the infection process.

PD - L1 binds to its receptor PD - 1 found on immune cells to downregulate their activity.

Normally, when the cat protein finds its way into the blood of an allergic person, antibodies called IgE grab it and bind to receptors on immune cells.

Researchers from immune biology professor Annette Oxenius's group have now discovered what keeps NK cells from killing off their «colleagues from the other department» of the immune system: healthy CD8 + cells are able to detect the immune messenger substance type 1 interferon, which binds to specific receptors on the surface of these immune cells and thereby conceals their stress.

Depending on characteristics such as how many tumor cells, blood vessel cells, and immune cells are touching each other, the tumor microenvironment can nearly triple the chance that a common type of breast cancer (estrogen - receptor positive / HER2 negative) that has reached the lymph nodes will also metastasize, Condeelis and colleagues showed in a 2014 study of 3,760 patients.

In CAR T therapy, a person's own T cells — disease - fighting immune cells — are removed and sent to a lab where they are genetically re-engineered to produce chimeric antigen receptors (CARs) on their surface.

Skeletal muscle fiber formation, bone marrow stem cell formation, thymus T - cell formation, TNF - a / INF - gamma production by immune system's macrophages (immunosenescence by IGF loss), neuregulin and brain - derived neutrophic factor depend on IGF - 1 acting on brain IGFR receptors.

The company showed how they first defined A2A as the receptor required for mediating the effect of adenosine on immune cells within the tumor microenvironment and reported the characterization of a novel immuno - oncology - dedicated adenosine receptor 2A antagonist that functions in the high adenosine concentration found in tumors.

The adenosine A2A receptor is the main adenosine receptor expressed on immune cells, which promotes immune suppression, leading to tumor evasion.

The adenosine A2A receptor is the main adenosine receptor expressed on immune cells, which promote anti-tumor immune responses, leading to tumor regression when inhibited with an adenosine A2A antagonist.

Binding of adenosine to the A2A receptor on immune cells blocks the activation and effector functions of anti-tumor immune cells and promotes a regulatory, immune - suppressive phenotype.