We are interested in evaluating the role of maternal viral load, immune activation and plasma cytokine environment on the neonatal
immune repertoire present at birth by measuring cord blood TCR diversity through amplification of the CDR3 region followed by sequence analysis of expanded clones.
One avenue of our translational research aims to determine the impact of in utero HIV - 1 exposure on infant immunity to vaccinations and co-infections by dissecting the infant
immune repertoire present at birth in the context of maternal HIV - 1 infection and how the infant T cell repertoire changes following early life exposures compared to infants born to the HIV - 1 uninfected women of similar socio - economic status.
Not exact matches
This work yielded the draft sequence of a waterfowl - duck for the first time, and the data indicated that the duck, like the chicken and zebra finch, possessed a contractive
immune gene
repertoire comparing to those in mammals, and it also comprises novel genes that are not
present in the other three birds (chicken, zebra finch and turkey).
This position, funded by Cancer Research UK, will explore whether manipulation of a novel antigen presentation checkpoint can enhance the
repertoire of tumour antigens
presented for
immune recognition.
Whilst there Sabrina
presented a poster showing her research work entitled: «The peripheral blood TCR
repertoire might facilitate patient stratification for
immune checkpoint blockade inhibition in metastatic melanoma.»