Sentences with phrase «immune response in the mouse model»

To test the role of innate immune response in the mouse model of ALS, the researchers focused on Toll - like receptors (TLR), which are important sensors for innate immunity.

A few interesting articles in early life human microbiome, plus: A comparison between Staphylococcus epidermidis commensal and pathogenic lineages from the skin of healthy individuals living in North American and India; A new tool to reconstruct microbial genome - scale metabolic models (GSMMs) from their genome sequence; The seasonal changes in Amazon rainforest soil microbiome are associated with changes in the canopy; A specific class of chemicals secreted by birds modulates their feather microbiome; chronic stress alters gut microbiota and triggers a specific immune response in a mouse model of colitis; and evidence that the short chain fatty acids profile in the gut reflects the impact of dietary fibre on the microbiome using the PolyFermS continuous intestinal fermentation model.

Her work focuses on using RNA vaccines for Leishmaniasis and prostate cancer to generate protective or therapeutic immune responses in mouse models and evaluate in an artificial lymph node system.

Not exact matches

Based primarily at Harvard with Maniatis, tenOever developed a knockout mouse model to study a particular protein, IKKε, that's involved in the immune response to viral infection.

When injected together with factor VIII into mouse models of haemophilia A, the nanoparticles deliver their payload to cells in the lymphoid tissue that are responsible for initiating immune responses.

The systemic response to surgery triggers the outgrowth of distant immune - controlled tumors in mouse models of dormancy

Combined treatment with two cancer immunotherapy drugs — one a novel immune modulator and one that focuses and activates the antitumor immune response — significantly prolonged survival in mouse models of the aggressive cancer malignant mesothelioma.

When STAT3 was knocked out in a mouse model, researchers observed increased T - cell immune responses, suggesting a valuable therapeutic target.

We find that a single administration of the MN patch induces robust immune responses in a B16F10 mouse melanoma model compared to MN without degradation trigger or intratumoral injection of free aPD1 with the same dose.

Hypothesis driven approaches to vaccinology can utilise the knowledge gained from mechanistic mouse models and our molecular understanding of intrinsic defects to human cells.5 However, caution is required when extrapolating data from murine models, as there are substantial differences between immune ageing in mice and humans.6 Nevertheless, model systems and ex vivo analyses of molecular alterations in aged human cells have identified multiple changes in the vaccination response with age and the aged immune system in general.

Our technological expertise ranges from the most fundamental approaches to study membrane transport in lymphocytes and dendritic cells (subcellular compartmentalization, intravital microscopy, phagosomal functions), the systematic analysis of gene expression and it regulation (RNAseq, Chip Seq, proteomics) and physiological and pathological immune responses (mouse models for cancer immunity, immunomodulation / vaccination, human clinical studies in cancer).

We chose this model because 1) it more closely recapitulates features of human pancreatic cancer than do s.c. - implanted tumors, 2) it can be used in immunocompetent mice to permit assessment of immune responses, and 3) the cells grow in vivo with predictable kinetics (34).

This research, funded by NIH, aims to test adenoviral recombinants based on simian serotypes for induction of immune responses to gag / pol / rev of HIV - 1 or SIV - 1 in a mouse model.

His most recent work, studying human skin tissues, confirms that these mouse models mimic the allergic immune response seen in humans.

Acute immune responses to Helicobacter pylori in the mouse model.

His lab has extensive experience evaluating and modulating T cell responses to tumors and viruses, including introducing genes into T cells to impart specificity and modulate function, designing strategies to overcome tolerance and enhance in vivo activity, and developing mouse models that more accurately model human immune responses to candidate vaccines.

Findings (i)- (iii) strongly resemble the changes seen after Abeta immunotherapy in mouse models of AD and suggest that the immune response generated against the peptide elicited clearance of Abeta plaques in this patient.

In 2010, we formally demonstrated ADE by developing a mouse mode of ADE - mediated disease, and we began to dissect the contribution of humoral vs. cellular immune components in dengue vaccine - mediated protection using model vaccine candidates as tools to probe the mechanisms by which the vaccine - induced immune responses in mice contribute to protection vs. ADIn 2010, we formally demonstrated ADE by developing a mouse mode of ADE - mediated disease, and we began to dissect the contribution of humoral vs. cellular immune components in dengue vaccine - mediated protection using model vaccine candidates as tools to probe the mechanisms by which the vaccine - induced immune responses in mice contribute to protection vs. ADin dengue vaccine - mediated protection using model vaccine candidates as tools to probe the mechanisms by which the vaccine - induced immune responses in mice contribute to protection vs. ADin mice contribute to protection vs. ADE.

The department of Immunology has a long tradition in studies of innate, mucosal, and placental, as well as classical acquired immune responses, in both human and experimental mouse models.

In summary, the TJU team's findings suggest that B. hermsii - infected humanized NSG mice are an excellent model for studying the pathogenesis of, and immune responses to, human relapsing fever.

At JAX's new Alzheimer's Disease Precision Models Center, Howell is genetically manipulating mice to understand how unhealthy lifestyle habits trigger immune responses in the brain, leading to a cascade of events that may ultimately impair thinking and memory, as in Alzheimer's disease.