Sentences with phrase «immune responses to»

Conceptually, the antigen - specific enhancement of Treg cell function is of particular importance because such strategies will minimize the requirements for pharmaceutical immunosuppression, sparing desired protective host immune responses to infectious and malignant insults.

Further histological analysis assessing immune responses found that compared to sham rats, all 3 - NP treated rats had higher numbers of activated microglia (CD11b +), gaining significance over the 3 - NP mice in the 3 - NP - iPSC - 7 and -42 rats, indicating possible local immune responses to the transplanted cells.

The investigators found that the immunized monkeys mounted antibody responses against diverse strains of HIV and the monkeys also mounted cellular immune responses to multiple regions of the virus.

Differential immune responses to HIV - 1 envelope protein induced by liposomal adjuvant formulations containing monophosphoryl lipid A with or without QS21.

Blood is the body's only site in which antigens are not handled by lymph nodes; instead, adaptive immune responses to blood - borne antigens are orchestrated entirely within the spleen.

We are particularly interested in leverage our interdisciplinary expertise in polymer chemistry, nanomedicine, drug delivery and immunobiology to innovate new approaches to modulate the tumor microenvironment and enhance cellular immune responses to cancer vaccines.

Dr. Anuja Mathew is the newest members of the iCubed team, joining the Institute in August 2015 to research human immune responses to dengue virus infections alongside world renowned Dr. Alan Rothman.

The scientists who posted this paper argued that a lot of people had immune responses to Cas9, because they knew that the two most widely used Cas9 enzymes come from S. aureus and S. pyogenes bacteria, and humans have been infected by these bacterias for a long time.

Jäger E, Ringhoffer M, Dienes HP, Arand M, Karbach J, Jäger D, Ilsemann C, Hagedorn M, Oesch F, Knuth A. Granulocyte - macrophage - colony - stimulating factor enhances immune responses to melanoma - associated peptides in vivo.

In particular we are focusing on the impact of diet on intestinal barrier function and the associated innate immune responses to modulate healthspan.

«Our results suggest a role for gestational maternal infection and innate immune responses to infection in the onset of at least some cases of autism spectrum disorder,» says first author Mady Hornig, associate professor of Epidemiology and director of Translational Research at CII.

These latter two cell types can mount effective immune responses to viruses and tumors; whereas, exhausted T cells fail and memory T cells, in particular, for long - lasting durable effects.

«He clearly didn't have any bad immune responses to the stem cells, so that's encouraging.»

levels, and their immune responses to the SGE were more likely to be Th2 - type cellular responses.

An added benefit is that MenAfriVac ® also boosts protective immune responses to tetanus, a painful bacterial disease that can cause involuntary muscle tightening and spasms sometimes strong enough to fracture bones and even cause death.

Most allergies are immune responses to proteins — peanuts, for instance, contain proteins that link up with antibodies in people who are allergic, triggering a reaction.

He teamed up with Robert Seder of the Vaccine Research Center (VCR) at the National Institute of Allergy and Infectious Diseases in Bethesda, Maryland, and scientists at other labs to test immune responses to the vaccine in animals.

She ultimately chose to study leukemia patients» immune responses to bone marrow transplants, an area conducive to translational research in part because the work involves treating patients with human cells, which can be prepared at academic health centers.

No data are yet available for trials in children, who typically have much less robust immune responses to the seasonal influenza vaccine and require a second dose.

Vitamin D is thought to protect against such attacks by boosting immune responses to respiratory viruses and dampening down harmful airway inflammation.

However, the new, larger study found that the effect of viral replication capacity was very early after infection, and was independent of both initial viral load and whether individuals carried certain protective variants of immune genes called HLA that positively influence immune responses to HIV.

«This study provides new insight into the pathways that regulate immune responses to commensal bacteria and maintain tissue homeostasis» adds Hepworth.

Dr. Gnjatic's research focuses on human antigen - specific immune responses to tumor antigens, in an attempt to define new targets for the development of cancer immunotherapies, assess the efficacy of these immunotherapies, and learn why they may fail.

In this study, we examined the effectiveness of a vaccination targeting tumors that produced IL - 15 and its cell surface receptor called IL - 15R - alpha -LRB--RRB- and examined their ability to up - regulate (or increase) immune responses to tumor antigens,» Morris says.

These drugs work by targeting the PDL - 1 receptor — a known immunotherapy biomarker for lung and other cancers — to boost immune responses to the cancer.

Scientists had thought that a mother somehow suppresses her immune responses to the baby, or that the placenta blocks her immune cells.

A human enzyme that can degrade the chitin of insect exoskeletons also regulates allergic inflammation in asthma, reinforcing the similarities between immune responses to parasitic and allergic stimuli.

This finding helps explain why immune responses to dengue are highly variable, and it has complex implications for epidemiology, disease, and vaccine deployment.

«In addition, the results of this study provide new mechanisms for how abnormal pigmentation associated with some melanocytic nevi and melanomas might arise as a result of immune responses to the growths.»

It is designed to learn more about the immune responses to the vaccine in different populations.

The short - term changes detected by fructosamine are also associated with changes in cytokine levels, another factor in promoting strong immune responses to infection.

In a phase 2 trial that included nearly 1,000 adults, the AS03 and MF59 adjuvants (a component that improves immune response of inactivated influenza vaccines) increased the immune responses to two doses of an inactivated H7N9 influenza vaccine, with AS03 - adjuvanted formulations inducing the highest amount of antibody response, according to a study in the July 21 issue of JAMA.

Low - dose and high - dose OIT were safe and equally effective at suppressing allergic immune responses to peanut, investigators found.

Walter and Eliza Hall Institute researcher Dr Melinda Hardy said the research was the first of its kind to comprehensively profile immune responses to oats in people with celiac disease.

A team led by Ron Dagan, a pediatric infectious disease specialist at Soroka University Medical Center in Beer - Sheva, Israel, wanted to know if a new pneumococcal vaccine based on tetanus toxoid would change infants» immune responses to the standard regimen of vaccines, including those for diphtheria, tetanus, pertussis (DTP), and Haemophilus influenzae type B, which protects against meningitis.

Dectin - 1 previously has been studied as a receptor that recognizes structures on fungi and other microbes and triggers immune responses to them.

«There is some evidence that men make weaker immune responses to some viruses than women, but how this happens and whether it is seen across all viruses is still unclear to me,» notes John Upham, professor of respiratory medicine at Queensland University in Australia.

This then activates immune responses to stop the pathogen and so protect the plant from infection.

They are referred to as serotypes 1 - 4 because, following infection, individuals have distinct antibody profiles in their blood serum, resulting from specific immune responses to each of the four virus types.

Those who had the strongest inflammation responses to the saline solution had the weakest immune responses to the VZV, suggesting that the excessive inflammation was inhibiting VZV - specific immunity.

These findings add to previous work showing bat - specific changes in other DNA sensors such as AIM2, IFI16, and TLR9 that elicit more harmonious immune responses to pathogens.

The company leverages its unique insights in cancer biology and the immune system to discover and develop novel oral small molecules that activate immune responses to eliminate cancer cells.

Sue warns that, if these hormones do have a profound effect on the immune system, then «men may not be exaggerating symptoms, but have weaker immune responses to viral respiratory viruses, leading to greater morbidity and mortality than seen in women.»

Researchers in my lab think that this impact of influenza infection on muscles is another unintended consequence of the immune response to the virus.

In addition, the buildup of mucous in the lungs, as a result of this immune response to infection, induces coughing as a reflex to try to clear the airways.

While this process causes some lung injury, most of the symptoms of the flu are actually caused by the immune response to the virus.

Treatment vaccines treat an existing cancer by strengthening the body's natural immune response to the cancer.

Her doctoral research investigated the immune response to infection with Yersinia pseudotuberculosis.

A food allergy is an immune response to protein to which an individual has become sensitised.

Celiac disease is an autoimmune disease that triggers an immune response to gluten.