Sentences with phrase «immune suppression in»

Dr. Matsuzaki has accumulated extensive expertise in T - cell biology and mechanisms of immune suppression in periphery and tumor microenvironments in patients with ovarian cancer.

The use of immune suppression in the treatment of autoimmune disorders and other diseases needs to be better individualised to prevent undue impairment of lung defences and severe secondary infections.

This approach has led to the finding that activated fibroblasts in the tumor stroma mediate immune suppression in several mouse models of cancer, including the autochthonous model of pancreatic ductal adenocarcinoma of the Tuveson lab.

iTeos» pipeline addresses key unmet needs in immuno - oncology: the inhibition of immune suppression in inflamed (hot) tumors and the increase of immunogenicity in non-inflamed (cold) tumors.

The mechanism which underlies the susceptibility of liver disease patients to life - threatening infection has been uncovered by Wellcome Trust - funded medical scientists, who have also suggested a possible treatment to reverse immune suppression in these patients.

The researchers plan to carry out a clinical trial looking at the ability of albumin to reverse immune suppression in liver cirrhosis starting this summer.

«Our research has uncovered a powerful mechanism for immune suppression in cirrhosis patients and also proposes a relatively simple and safe treatment.»

«Mechanism, possible treatment, for immune suppression in liver disease uncovered.»

However, he says, it's unclear whether Olthoff's technique would prevent immune suppression in people.

Meanwhile, Van den Eynde and his team are already hard at work looking for the other novel mechanisms of immune suppression in their model.

Not exact matches

Dioxin is carcinogenic and has been linked to birth defects, skin disease, liver disease, immune system suppression & genetic damage in lab animals.

She's going to start immune suppression right in the beginning of winter.

In particular, two molecules known to play a role in cancer's suppression of the immune system are PD - L1 and galectin - In particular, two molecules known to play a role in cancer's suppression of the immune system are PD - L1 and galectin - in cancer's suppression of the immune system are PD - L1 and galectin - 9.

In the placenta, RDGs have been found working in pathways associated with many of the tools of invasion: immune suppression, blood vessel growth, cell proliferation, and inflammatioIn the placenta, RDGs have been found working in pathways associated with many of the tools of invasion: immune suppression, blood vessel growth, cell proliferation, and inflammatioin pathways associated with many of the tools of invasion: immune suppression, blood vessel growth, cell proliferation, and inflammation.

The gene signature identified by Hancock and his colleagues relates to a special type of immune suppression called cellular reprogramming and suggests that treating inflammation in sepsis is a bad idea.

«If you give patients immune cells to eradicate any remaining cancer cells that might be present,» he says, «those immune cells would not be prevented from doing their job by ongoing immune suppression drugs that are being used in patients treated with conventional transplant approaches.»

Researchers from Swinburne University of Technology identified plant species that could potentially be applied in the management of type 2 diabetes and related complications of weight gain, hypertension and immune suppression.

«Our studies imply that the change of oxygen levels in different tissues can be sensed by Treg cells and that this process is critically important for maintaining the correct balance between activation and suppression of the immune system,» says Liu.

Researchers have had some success in transplanting islet cells, but recipients require heavy doses of immune suppression.

Less suppression of the immune response and less blood vessel formation in the tumor leads to less tumor growth.

Findings from a study in animals appear to demonstrate that temporarily blocking a type of protein, called type I interferon, can restore immune function and speed up viral suppression during treatment with anti-viral drugs for people with chronic infection of the virus that causes AIDS.

Research has already shown that immune response provided by nasal mucous membranes is compromised in cigarette smokers, which causes them to be more susceptible to the outcomes of a viral infection, said Ilona Jaspers, deputy director of the Center for Environmental Medicine Asthma and Lung Biology at the University of North Carolina at Chapel Hill, but her new research revealed even more immune suppression effects in e-cigarette users than in smokers of traditional cigarettes.

These cells, in turn, instruct factor - VIII — specific immune cells to become tolerant to the coagulation protein, resulting in suppression of misdirected antibody responses to the replacement therapy — all without affecting the rest of the immune system.

Because previous work in rats and monkeys has found that proteins that block the costimulatory signal can hold T cells at bay, Kim Olthoff, a transplant surgeon at the University of Pennsylvania Medical Center in Philadelphia, thought her team could achieve a targeted immune suppression by getting the transplanted organ itself — rather than proteins injected into the bloodstream — to block the costimulatory signal.

Surprisingly, the researchers detected levels of viruses in sepsis patients that were on par with those seen in patients who have had organ transplants and are taking immune - suppression drugs to prevent rejection.

«Because JAK3 has such an isolated role in the immune system, we believe that inhibiting it will lead to a suppression of immune responses which could be used to treat autoimmune disorders like psoriasis and rheumatoid arthritis.

They say more research is needed to understand whether this level of virus suppression would be enough to halt disease transmission, and they are working on other experiments to see if they can produce antiviral factors in the gut, which could assist in inducing a stronger immune response and possibly confer resistance to the other viruses.

«Our work has shown that overcoming brain tumor - induced immune suppression is critical for enhancing efficacy of anti-tumor immunotherapies,» says first author Neha Kamran, Ph.D., a U-M neurosurgery research fellow in the Castro / Lowenstein Lab.

«It's surprising, because [suppression of the immune system is] not what the field has been thinking is happening in AD,» Kan said.

In light of the new findings, the researchers think current immune - suppression strategies should be re-evaluated in lung transplantatioIn light of the new findings, the researchers think current immune - suppression strategies should be re-evaluated in lung transplantatioin lung transplantation.

Just as in a human, the rabbit's immune suppression system would see this new organ as an invader and attack.

The researchers suggest that primates such as baboons and humans have benefited from an «evolutionary flexibility» in how they respond to stress and that immune suppression is not always the result.

Such a treatment in humans, Glick says, might have fewer side effects than the immune - suppression drugs currently used to treat the condition.

By blocking a specific cell signaling pathway in lab animals, researchers reversed signs of chronic immune activation, thereby boosting T - cell recovery and viral suppression.

Aflatoxins in fungi have been linked to stunted growth in children, liver cancer, and immune suppression.

Several reports indicated that B cells can mediate immune suppression and negatively affect the antitumor immune response in several cancer types.

This suggests that in the children who fail to respond to the oral polio vaccine, bacteria are leaking out of the gut and induce an overstimulation of the immune system, which paradoxically results in suppression of the response to the vaccine.

In recent years, therapeutics aiming to restore the tumor suppression function of the immune system have shown impressive clinical results, but not all cancer patients benefit from these.

Bottom Line: Bacterial load was significantly higher in pancreatic tumor samples from patients with pancreatic ductal adenocarcinoma compared with pancreatic tissue from normal individuals, and in studies using mice, eliminating certain «bad» bacteria slowed the growth of pancreatic cancer, reversed immune suppression, and upregulated the immune checkpoint protein PD1.

In summary, our results point to both a significant «vacation effect» that benefitted all groups, and a suppression of stress - related responses and immune function related to acute - phase wound healing and inflammation.

In patients who are cured, the long term side - effects of the chemotherapy and immune suppression treatment as well as any graft versus host disease.

Intriguingly, we also found that rare individuals moved out of the IRP category by a process of immune suppression, including increases in IL - 6 and IL - 10 and decreases in the number of CD3 + CD8 + CD28 - cells.

JDRF and ViaCyte share a continuing commitment to realizing the potential of beta cell replacement strategies to deliver insulin independence without immune suppression for people living with type 1 diabetes, and ultimately, at JDRF we hope this will move us forward in fulfilling our vision of a world without type 1 diabetes.»

The goal of this study was to assess if immune suppression followed by postnatal thymus transplantation would lead to T - cell function in 6 infant patients who had host T cells at the time of transplantation.

These findings are in agreement with previous studies that show that xenografts can be compromised [4], [44] even after triple immune suppression [45].

Although red therapy light helps to modulate the immune system, a 2006 study with mice found that over treatment actually resulted in immune suppression.

«It has been implicated in the development of Type 1 diabetes — probably related to its immune suppression and role in GI tract inflammation.»

Squamous cell carcinomas in people of color, especially African Americans, are often associated with other conditions (such as a non-healing wound or immune suppression), he says, and this skin cancer type has a worse prognosis than when it strikes fair - skinned people.

-- immune system suppression — rise in cholesterol and triglycerides — allergies — pancreas damage — headaches, including migraines — high blood pressure

There is a delicate balance of activity and suppression taking place every moment of every day in our immune systems, and utilizing the strategies above allow us to be proactive in maintaining this balance.