Sentences with phrase «immune surveillance»
"Immune surveillance" refers to the process where the immune system constantly watches and protects the body against the growth and spread of harmful cells, including cancer cells. It acts as a defense mechanism, identifying and eliminating abnormal or dangerous cells to maintain the body's health. Full definition
In turn, it appears microbes on the skin tweak the complement system, as well as immune surveillance of the skin.
sciencedaily.com
But cancer cells can escape immune surveillance using a variety of techniques to disguise themselves.
In turn, it appears microbes on the skin tweak the complement system, as well as immune surveillance of the skin.
Escape from immune surveillance is believed to be a primary feature of malignant disease in humans.
Italian and American researchers report that the PD - 1 (programmed cell death protein 1) / PD - L1 (ligand 1) axis is a key player in immune surveillance in hematologic malignances.
These allogeneic cells have the potential to participate in immune surveillance for breast or other cancers as observed in clinical hematopoietic stem cell transplantation.
After an initial acute disease state, that is kept in check by host immune response, bacteria as Pseudomonas aeruginosa and Staphylococcus aureus can establish persistent infections and colonize the host by evading immune surveillance.
«T - cell presence in tumors can be associated with immune surveillance and improved patient survival,» explained Beg.
By integrating the aforementioned observations of FMc in autoimmunity and transplantation immunobiology, we reasoned that allogeneic FMc might provide immune surveillance for breast cancer in parous women.
«The cells we found perform immune surveillance and contain the virus in the key battlefield where infection occurs, which is the dermal - epidermal junction,» said Zhu.
«The whole body is under immune surveillance all the time.
«Promising way to boost body's immune surveillance via p53 in fight against cancer.»
The molecule regulates genes that suppress immune surveillance mechanisms, including the production of cells that inhibit the immune response.
«New mechanism allowing tumor cells to escape immune surveillance discovered.»
«This is a whole new way of looking at immune surveillance in the epithelium of the human gut and airway,» said Lo, a distinguished professor in the medical school's Division of Biomedical Sciences.
TRAIL is a natural antitumor protein that suppresses tumor development during immune surveillance, the immune system's process of patrolling the body for cancer cells.
As a postdoctoral fellow in the Department of Biochemistry at Trinity College, Dublin, she uncovered a new adapter molecule and new immune surveillance receptors, and was subsequently awarded a Wellcome Trust International Research Fellowship.
Allogeneic cells, particularly mismatched or haploidentical cells, in the context of hematopoietic transplantation have been found to provide potent immune surveillance for both hematologic and solid tumor malignancies in a process referred to as graft - versus - tumor [13]--[15].
One possible role of FMc in healthy women might be the provision of allogeneic immune surveillance for (pre --RRB- malignant cells.
Warren Alpert Foundation Honors Five Pioneers in Cancer Immunology Scientists recognized for seminal discoveries in cancer's ability to thwart immune surveillance that paved the way to immune - based cancer therapies.
Residing in the epithelial cells that line our skin and gut are specialised T cell compartments that run tight immune surveillance on local tissues.
CMB305 may also generate memory CTLs, and therefore long - term immune surveillance, as well as enhance other immune anti-tumor mechanisms.
Immunoglobulin A, or IgA, is one of the body's class of antibodies or immune surveillance proteins.
The histiocyte group of cells are part of the body's immune surveillance system.
Interestingly tumor cells, whilst not allogeneic, are in many cases both «altered - self» and immunogenic but often actively modulate immune responsiveness to evade immune surveillance 76.
They found that genes associated with immune surveillance were downregulated in the skin in inhibitor - treated animals, as was the number of immune cells overall.
These antibodies are typically involved in immune surveillance, but in this case they promote the myelination of axons.»
When ICZ binds to and activates the Aryl hydrocarbon receptor (AHR) in the intestinal lining, it aids in maintaining a healthy balance in the gut flora and immune surveillance, and enhances host barrier function, according to the researchers.
«We present an interdisciplinary approach to studying immunotherapy and immune surveillance of tumors,» said Benjamin Greenbaum, PhD, the senior author, who is affiliated with the departments of Medicine, Hematology and Medical Oncology, Pathology, and Oncological Sciences at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai.
«The brain is invisible to certain kinds of immune surveillance,» says Lisa Boulanger, a neurobiologist at the University of California, San Diego.
Using the JEDI technology, Mount Sinai researchers uncovered evidence that immune cells can find cells in the brain expressing their target antigen, even in non-infected states, which provides evidence of an immune surveillance pathway within the body's central nervous system.
Research in the UCR School of Medicine laboratory of David Lo found that certain cells of the epithelium have a potentially important role in immune surveillance — creating an electrostatic repulsion field to microbial invasion.
Further, depleting either NK cells or T - cells in mice led to increased tumor incidence, suggesting that both innate and adapative immunity contribute to immune surveillance.
«The study of PD - 1 / PD - L1 axis in hematologic malignancies highlighted the importance of immune surveillance to cure these diseases.
Autologous stem cell transplantation was one of the first forms of immune regenerative treatments to show that patients can have long term disease free survival after the transplant by re-instatement of immune surveillance.
«This pathway enables multiple tumor types to evade immune surveillance.
Building on each other's work, the five award recipients demonstrated how this normal self - defense mechanism can be hijacked by tumors as a way to evade immune surveillance and dodge an attack.
Researchers in this area focus on various aspects of immunology and infection, including mechanisms of infection processes, host - pathogen interactions, cellular and organismal immune systems, immune surveillance, innate immunity, viral entry and replication, microbial pathogenesis, antibiotic resistance, bacterial toxins, vaccine development and microbial diagnostics.
These findings establish a role for Ccr6 in augmenting innate - like lymphocyte responses to lymph - borne pathogens, and they define requirements for cell movement between parenchyma and SCS in what we speculate is a program of immune surveillance that helps achieve LN barrier immunity.
If we project this micro event into the cosmos of our overall biology, our metabolic function becomes run down, immune surveillance is compromised, causing us to slide into a constellation of possible diseases and disorders.
«ILCs are essential for immune surveillance of the digestive system and this is the first time that we have identified a gene responsible for the production of ILCs.»»
«ILCs are essential for immune surveillance of the digestive systemand this is the first time that we have identified a gene responsible for the production of ILCs.»»
Increased stimulation of these defense cells (natural killer cells) leads to better immune surveillance and a lower likelihood that a virus or bacteria can set up in your body and create an illness.
The significance of these findings is not known, but may indicate focal aberrations in immune surveillance.