Sentences with phrase «immune system cells into»

These memory cells then lead other immune system cells into battle against invaders.

Not exact matches

Or consider a vaccine that, when injected directly into a tumor, would not only destroy the malignant cells but also stimulate the body's immune system to go after similar tumor cells.

The drug has an unfortunate side effect of tricking the immune system into attacking healthy cells, but the relative damage was insignificant compared to what cancer would have done to them.

The old episode on the immune system took us into the blood vessels and showed us the drama of white blood cells marking strep bacteria for death, then engulfing and digesting them.

Autoimmunity is commonly caused by bacterial infections or overgrowth in the small intestine, in which partially digested food compounds are incorporated into bacterial cell walls and then the immune system, reacting to the bacteria, forms antibodies that also recognize food compounds, some of which might cross-react with human counterparts.

A decade ago a drug based on an internal protein of the flu virus, called NP (for nucleoprotein), set the immune system's killer T cells into action, but it only partially protected mice from the flu.

But during pregnancy, the fetus is protected from the mother's immune system by the placenta, which has specialized cells — called trophoblasts — that can burrow into the mother's body without exciting an attack by the immune system.

The goal of the new approach is to convert that immunosuppressive environment into an «immunostimulatory» one, Goldberg says — a condition in which the immune system is primed for an offensive against cancer cells.

In reaction to infection or inflammation, immune system cells known as effector T cells (Teffs) undergo rapid changes - arming themselves and diversifying into groups that target specific diseased cells.

A second type of immune system cell, called regulatory T cells (Tregs), are a model of constancy, remaining stable even as Teffs go into battle mode.

The inner surface is «greasy» and is believed to interact with cell membranes, while the outer surface, once secreted into the blood, can interact with the patient's immune system.

But if you put that same virus into a rhesus macaque, the monkey's immune system reacts similarly to that of humans; there is severe depletion of CD4 T cells and progression to AIDS, explains U.C.S.F. researcher Peter Hunt.

Researchers at Penn State have combined the two approaches by taking biodegradable polymer nanoparticles encapsulated with cancer - fighting drugs and incorporating them into immune cells to create a smart, targeted system to attack cancers of specific types.

Researchers injected both the naked virus and SEVI - treated HIV into the tails of rats that had been given human immune system cells.

The researchers found that HIV spiked into semen was more successful than the virus alone at infecting T cells and macrophages (immune system cells that are believed to be the infection's initial targets in the body).

The drug blocks CTLA - 4, a protein receptor on the surface of T - cells that serves as a molecular stop sign, preventing the immune system from going into overdrive.

To create mouse avatars, researchers implant some of a patient's cancer cells into rodents lacking a normal immune system and measure whether various drugs destroy the tumors that sprout in the animals.

Ultimately, the team hopes to inject BMP - 7 directly into the pancreas to stimulate the creation of new beta cells, allied with a small amount of immunosuppressive drugs to stop the new insulin factories being destroyed by the immune system.

Another possibility would be to create new beta cells from donated pancreases, and package them into materials that shield the cells from the immune system.

Adenoviruses can deliver foreign genes into mammalian cells, but within 3 to 4 weeks the immune system kills cells that have taken up the virus.

Then it infects various cells of the immune system, which it tricks into making more copies of itself.

Hoping to treat the fetus when its immune system was especially primitive and the disease in a nascent stage, doctors infused stem cells into the fetus's abdominal cavity at just 12 weeks» gestation.

They've figured out how to turn human stem cells into functional pancreatic β cells — the same cells that are destroyed by the body's own immune system in type 1 diabetes patients.

After an initial infection, HSV - 1 goes into hiding in nerve cells, where it eludes the immune system's sentries.

Converting these cells into regulatory T cells could help reduce the hyperactivity and return balance to the immune system, thus treating the root of the disease.

One likely reason for this is that animals undergo cellular differentiation; human life begins as a single cell that differentiates into the various cell types needed for different organs, body parts, blood, the immune system, etc..

More precisely, they discovered how to turn pro-inflammatory cells that boost the immune system into anti-inflammatory cells that suppress it, and vice versa.

The researchers then introduced the two strains into mice transplanted with a human immune system and watched in real time as HIV spread from one CD4 + helper T cell to another.

The capsule protects the donator's cells against attacks of the immune system but, passes the hormones by semi-permeable walls into the body of the receiver.

When a T cell detects one, it morphs into a fighting machine, zapping invaders with lethal chemicals, multiplying into an army of identical killers or signaling other immune - system troops to join the attack.

Affecting the central nervous system, it causes neonatal meningitis by multiplying in immune cells, such as macrophages, and then disseminating into the bloodstream to subsequently invade the blood - brain barrier.

Rick Maizels at the University of Edinburgh and his colleagues find that the worms manipulate their hosts into producing cells called regulatory T cells, which calm the immune system.

The findings of the research are to be published in the December 2014 issue of the scientific journal Immunity, a Cell Press journal that specialises in publishing high - impact research into the function of the immune system.

This virus inserts its genome into the body's memory cells and sits there quietly avoiding detection by the immune system,» Associate Professor Palmer explained.

Tumors protect themselves by tricking the immune system into accepting everything as normal, even while cancer cells are dividing and spreading.

But if a person's immune cells hover on the verge of hyperactivity, cytomegalovirus could push the system into danger.

«Imagine that the pathogen injects directly into the plant cell a protein that mimics part of a particular immune system machine.

«Research into basic workings of immune system points to way of improving therapies for cancer: Differences in wiring of «exhausted» and effective T cells indicate possible gene - editing targets.»

Once the particles get into cells, the RNA is translated into proteins that are released and stimulate the immune system.

These then grow into all types of blood cells, including the white blood cells of the immune system.

The findings provide new insights into the immune system's T cells, each of which possesses receptor proteins that allow it to recognize a specific pathogen.

It's believed that in type 1 diabetes, the body's immune system destroys the pancreatic beta cells responsible for making insulin, a hormone the body needs to convert food into energy.

They systematically deleted genes for secreted effector proteins — molecules that the parasite injects into a host cell to modulate the immune system during infection — and injected the altered parasites into mice with aggressive ovarian cancer.

Wu, who is also a professor of cardiovascular medicine and of radiology, said, «This study certainly makes us optimistic that differentiation — into any nonpluripotent cell type — will render iPS cells less recognizable to the immune system.

Key immune system cells produced before birth may survive well into adulthood, according to new research published in PLOS Computational Biology.

Monitoring immune cell activity — including phenotyping immune cell subsets, tracking cell proliferation, and measuring cytokine production — can provide insights into the overall status of immune function in patients, particularly those undergoing immunosuppression after transplants, enduring cancer treatment, or suffering from autoimmune disease or other pathologies that affect the immune system.

Areas covered range from basic studies into the biology of innate and adaptive immunity (immune cell development and differentiation, immunogenomics, systems immunology, structural immunology, antigen presentation, immunometabolism, and mucosal immunology) to immune contributions to health and disease (host defense, inflammation, cancer immunology, autoimmunity, allergy, transplantation, and immunodeficiency).

The human immune system is poised to spring into action at the first sign of a foreign invader, but it often fails to eliminate tumors that arise from the body's own cells.

HIV - 1 integrates its own genome into the genome of human immune system cells known as CD4 + T cells, hijacking their cellular machinery to make more copies of itself.

If this were disabled, then the parasite would produce just one PfEMP1 protein, allowing the immune system to swing into action and destroy infected cells.