Sentences with phrase «immune system interaction»

• New human - specific biomarker identification and new drug discovery is possible using Organ - Chips, based on new insights into biological pathways of disease and immune system interaction.

This is conducted through the understanding of immune regulation and tumor - immune system interaction and translating the findings into therapeutic approaches.

Not exact matches

Alterations in this interaction between breast milk and the infant's immune system are thought to contribute to disease development.

The reasons for this controversy lie in the complexity of the interaction between breast milk and the infant's intestinal environment and immune system.

Some researchers have revealed that postpartum preeclampsia is caused by the change of interaction between placenta and immune system.

It is also good to allow kids to have moderate interaction with less - than - perfectly clean spaces, so as to encourage a healthy immune system.

«Chronic inflammation of the intestine is thought to be caused by abnormal interactions between gut microbes, intestinal epithelial cells and the immune system, but so far it has been impossible to determine how each of these factors contribute to the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the intestines.

«Cardiac stem cells from heart disease patients may be harmful: Researchers discover molecular pathway involved in toxic interaction between host cells and immune system.»

Researchers have revealed the molecular structure of a protein produced by the Zika virus that is thought to be involved in the virus's reproduction and its interaction with a host's immune system.

We now know that the immune system is very likely a key player in many neurological diseases and, surprisingly, that immune - CNS interactions may not all be bad.

Luis Martinez studies the interactions of infectious microbes with the immune system, focusing on fungal and bacterial infections affecting immunocompromised individuals.

This interaction activates MALT1 to cleave and inactivate a number of cellular proteins that normally keep the immune system in check.

«We set out to map out interactions between bacteria and the immune system in the hope that this could eventually lead to the development of an apothecary of agents tailored to modulate the immune system selectively and precisely,» said senior investigator Dennis Kasper, professor of medicine and microbiology and immunobiology at HMS.

But exactly how the immune system works remains, in many ways, a mystery, as there are numerous cell types whose functions and interactions with our immune systems have not been well understood.

TEDDY researchers next plan to look at factors including interaction between genes and the environment, including examining how diet affects bacteria in the gut and the immune system of children with differing genetic risks.

«We know there's an interaction between stress hormones and the immune system,» she says.

Enhancing such an interaction, perhaps in combination with other therapies that attack the virus at other stages of its life cycle, could give the immune system the opening it needs to overcome an infection.

This is an illustration showing interactions between components of the AH10 - 7 compound (yellow), an immune system antigen - presenting cell (gray), and an invariant natural killer T cell (green and blue) that spark activation of iNKT cells in «humanized» mice.

«Not only does this report shed light on how colds exacerbate asthma, it also suggests new pathways and existing drugs that might be exploited to limit this, in some cases, severe combination of respiratory events,» said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology, «These findings also highlight an emerging appreciation for the interaction between metabolic pathways and the immune system.»

Information about interactions between the immune system and the virus, which influence the set point level are therefore of crucial importance.

Her work seeks to elucidate the mechanisms and pathways underlying the interaction between the immune system and cancer using mouse models that recapitulate the coevolution of tumor progression and the antitumor immune response.

Dr Mattarollo said psychoneuroimmunology — or the interaction between the mind, the nervous system and the immune system — is a rapidly growing discipline and is becoming an increasing focus of the lab's cancer research.

A University of Michigan - led team has revealed the molecular structure of a protein produced by the Zika virus that is thought to be involved in the virus's reproduction and its interaction with the host's immune system.

Source: Brown, Akey, et al., Nature Structural and Molecular Biology.ANN ARBOR — Researchers have revealed the molecular structure of a protein produced by the Zika virus that is thought to be involved in the virus's reproduction and its interaction with a host's immune system.

Hence, we merged our expertise in evolutionary biology and immunology to study the complex interactions between the vertebrate immune system, composed of a myriad of different cells, and the gut microbiota, composed of another myriad of different bacteria.

With respect to biological applications, the group is focusing on how cellular heterogeneity and cell - to - cell communication drive ensemble - level decision - making in the immune system, with an emphasis on «two - body» interaction (e.g., host cell - virus interactions, innate immune control of adaptive immunity, tumor infiltration by immune cells).

NEW YORK and SEATTLE — April 5, 2018 — The Cancer Research Institute (CRI), Institute for Systems Biology (ISB) and Sage Bionetworks — three organizations on the forefront of cancer immunotherapy, systems biology and bioinformatics — today announced the release of the Cancer Research Institute iAtlas, a comprehensive web - based tool that allows oncologists and researchers to study and analyze interactions between tumors and the immune microenvirSystems Biology (ISB) and Sage Bionetworks — three organizations on the forefront of cancer immunotherapy, systems biology and bioinformatics — today announced the release of the Cancer Research Institute iAtlas, a comprehensive web - based tool that allows oncologists and researchers to study and analyze interactions between tumors and the immune microenvirsystems biology and bioinformatics — today announced the release of the Cancer Research Institute iAtlas, a comprehensive web - based tool that allows oncologists and researchers to study and analyze interactions between tumors and the immune microenvironment.

Research Interests: Inflammatory bowel disease (IBD); Crohn's disease; ulcerative colitis; animal models of IBD; mucosal T - cell death and survival; tolerance to gut microbiota; interactions between immune and non-immune cells; immune - driven angiogenesis and lymphangiogenesis; intestinal fibrosis; intestinal myofibroblasts, extracellular matrix; systems biology; complex diseases

Systems biology research will aim to identify and validate mathematical models that can accurately predict interactions between immune system components in relation to vaccination, as well as develop state - of - the - art methods for the structural and functional analysis of vaccine candidates.

CIVIR's mission is to develop technologies to investigate the dynamic interactions between the immune, vascular and nervous systems as a way to better understand the origins and progress of neurological diseases.

Research interests: Evolution of the primate immune system, human immune function variation, socioecology of immunity, innate immunity, severe bacterial infections, host - pathogen interactions, immunogenomics, evolutionary medicine

Through understanding the biology of cancer cells and their interaction with the immune system we are able to discover and trial novel therapies to induce the immune system to detect and fight cancer cells.

For understanding the biology of gene - gene, gene - drug and gene - microenvironment interactions, a considerably broader range of in vitro and in vivo model systems is required — we are generating 1,000 organoid cultures from human cancers, characterising their genomes, functional dependencies and drug response, and we are expanding our in vivo models to study the interface between cancer and the immune system and microenvironment.

8.30 Hana Paculová CDK12 connects transcriptional regulation to DNA damage repair pathway 8.55 Karol Kaiser Wnt secretion during nervous system development 9.20 Simona Hankeová The role of Notch signaling in vasculogenesis 10.00 Coffee break 10.30 Tomáš Doležal Extracellular adenosine regulates complex host - pathogen interactions through the energy release for the immune response 10.55 Ondřej Bernatík and Igor Červenka Regulation of diverse function of Dvl by phosphorylation 11.20 Jan Ryneš Dissection of Axin interactome: rational approach for control of signaling cascades via intervention with specific protein - protein interactions 12.05 Targeting opportunities: discussion & sum - up 13.00 Lunch and departure

Inflammatory bowel disease represents a complex interaction between genetics, gut bacteria, the body's immune system, and the environment.

This novel approach, which reveals complex interactions between cells and proteins, can also be used for other diseases to generate new knowledge about the regulation and dysregulation of the immune system, which can eventually give rise to new, improved immunological therapies.

She is broadly interested in using computational techniques to model the in - host population dynamics of viral infections, and is particularly interested in modeling the interactions between Human Immunodeficiency Virus and the immune system.

The interaction of A. fumigatus and other airborne fungi with the immune system is increasingly linked to severe asthma and sinusitis.

Briggs» research has a two - pronged approach: One focuses on the innate immune system of plants, while the other delves into mass spectrometry technology so that researchers can see directly protein dynamics and interactions on a large scale.

Hereditary investigations revealed that some degree of inbreeding occurred during these interactions, which scientists said has led to some beneficial traits in modern humans such as having a strong immune system.

Since their first work together in 2000, Collmer and Martin have sought to tease apart the interactions between effectors and plant defense proteins, to understand how and when the plant's immune system responds.

It is believed that T1D results from complex interactions between multiple genes, environmental factors and the immune system, and the autoimmune aspects may begin many years before the clinical manifestation of T1D.

Stephen Alexander, UK - Cannabinoid receptors, transporters, endocannabinoid turnover, hydrogen sulphide turnover Arthur Christopoulos, Australia (GPCRs Liaison)- G protein - coupled receptors; analytical pharmacology; allosteric modulation; biased agonism; drug discovery; neuropharmacology John Cidlowski, USA (NHRs Liaison)- Glucocorticoid receptor signaling; apoptosis and the immune system Anthony P. Davenport, UK (Chair Evolving Pharmacology, GPCRs Liaison) Doriano Fabbro, Switzerland - Kinases and their biology, kinase inhibitors, drug discovery, pharmacology of drugs (kinase inhibitors) in the indication oncology, biology of oncology Kozo Kaibuchi, Japan Yoshikatsu Kanai, Japan - Transporters, amino acid signals, epithelial function, cancer biology Francesca Levi - Schaffer, Israel - eosinophils and mast cells as effector cells in allergic inflammation: characterization of new receptors / ligands, hypoxia / angiogenesis and eosinophils, asthma, atopic dermatitis, allergic rhinitis, immunopharmacological modulation of allergic diseases by bispecific recombinant antibodies, bacteria interactions with eosinophils and mast cells, the allergic effector unit, mast cell derived tumors: new antibody based treatment, the allergic inflammation and the resolvome, non IgE - mediated mast cell activation in diseases Eliot H. Ohlstein, USA (Editor)- Drug discovery and development, urogenital biology, cardiovascular / metabolic medicine John A. Peters, UK (LGICs Liaison) Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Joerg Striessnig, Austria (VGICs Liaison)- Physiology, pharmacology and pathophysiological role of voltage-gated calcium channels

As the cancer field saw successes with immunotherapies that could boost patients» immune responses to cancer, Swanton turned to studying how heterogeneity within a tumor influences its interaction with the immune system.

100/2: 45 Genome - wide interaction study of Parkinson disease and vitamin D deficiency implicates immune system pathways.

Uppsala, Sweden (Scicasts)-- Dynamic interactions between the nervous system, hormones and the immune system are normally on - going but in diabetes the balance is disturbed.

• Disease - driving pathways that involve the human immune system are often targeted by antibodies, and Organ - Chips recreate complex interactions of different human cell types and aspects of the human immune system, overcoming limitations of animal models which do not reflect all human immune cells.

Dr. Locksley's laboratory focuses on tracking cytokine expression in model systems, as a mechanism to investigate complex functional interactions between innate and adaptive cells in the immune system.

During these interactions, genetic and chemical screens converge on Mtb enzymes, helping the organism resist sterilization by the immune system.

Background & aims: Interactions between commensal microbes and the immune system are tightly regulated and maintain intestinal homeostasis, but little is known about these interactionInteractions between commensal microbes and the immune system are tightly regulated and maintain intestinal homeostasis, but little is known about these interactionsinteractions in humans.