Sentences with phrase «immune system pathways»

100/2: 45 Genome - wide interaction study of Parkinson disease and vitamin D deficiency implicates immune system pathways.

Because it's usually accompanied by allergies, scientists have wondered whether the same immune system pathways may be to blame.

The researchers found that these immune system pathways were suppressed in a large number of primary tumors — roughly 50 percent of ovarian cancers studied, 40 percent of colorectal cancers and 30 percent of breast cancers.

Not exact matches

In a new study published in the Journal of Allergy and Clinical Immunology, Paller, the Northwestern Medicine chair of dermatology, together with Dr. Emma Guttman - Yassky of Mount Sinai Medical School, discovered that an arm of the immune system — the Th17 pathway — in these patients is way too active, and the higher its activity, the worse the disease severity.

«Cardiac stem cells from heart disease patients may be harmful: Researchers discover molecular pathway involved in toxic interaction between host cells and immune system.»

«The human genes and pathways that Tat manipulates correlate well with symptoms observed in these patients, such as immune system hyperactivation, then weakening, and accelerated aging,» Dr. D'Orso said, describing the situation in which HIV infection leads to AIDS.

«An exaggerated inflammatory response among cellular elements of the innate immune system can drive the adaptive immune system down an allergy - associated T H2 pathway,» said Vuillermin.

Two years into her research on a mouse - model study of a gene pathway's role in the immune system, she joined UCB Celltech.

Using the JEDI technology, Mount Sinai researchers uncovered evidence that immune cells can find cells in the brain expressing their target antigen, even in non-infected states, which provides evidence of an immune surveillance pathway within the body's central nervous system.

However, the Moffitt scientists suggest that it may be possible to target the TGF - β - miR183 - DAP12 pathway in patients with lung cancer to activate the immune system and kill cancer cells.

They identified a panel of 80 biological pathways commonly increased in expression by AZA in all three cancers, finding that 16 of them (20 percent) are related to the immune system.

IL - 17 is in a signaling pathway that acts as a feedback loop for the immune system.

«We have achieved the important goal of helping these young patients and made progress in understanding the biological pathways and proteins that are important for the regulation of the immune system's responses.»

Understanding how this immune system is regulated at the appropriate level of activity gives the researchers more ideas of points in the immune signaling pathway that could targeted to increase the plant's baseline ability to resist disease.

Dr. Sharma is a trained medical oncologist and immunologist whose research work is focused on investigating mechanisms and pathways within the immune system that are responsible for tumor rejection and clinical benefit.

«The results suggest that ploidization may offer yet another pathway to which DFTD is able to adapt to the ever - changing evolutionary landscape sculptured by the devils» immune system.

The identification of this two - stage pathological reflex arc — consisting of nerve pathways between the spinal cord and the adrenal glands, as well as a hormone - mediated link with the immune system — helps to deepen our understanding of the interconnections between the nervous and immune system.

Knowing this, Dimopoulos and his colleagues were able to manipulate a component of the immune system, the JAK - STAT pathway, that regulates production of antiviral factors.

«Not only does this report shed light on how colds exacerbate asthma, it also suggests new pathways and existing drugs that might be exploited to limit this, in some cases, severe combination of respiratory events,» said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology, «These findings also highlight an emerging appreciation for the interaction between metabolic pathways and the immune system.»

Stylized representation of a newly - discovered signaling pathway active after spinal cord injury, which sees the injured central nervous system use adrenal hormone production to potentially disrupt the immune system in a way that lead to severe infections.

«Making our inhibitors available could take basic research and the understanding of JAK signal pathways and their role in guiding the immune system a big step further in the future,» Laufer says.

Once they identified this pathway, Hanks and colleagues conducted laboratory tests of a molecule that blocks melanoma cells from going stealth, enabling the immune system to mount a direct attack while also enhancing the function of current immunotherapies such as pembrolizumab and nivolumab.

Second, affected genes may disturb fundamental pathways in the body and lead to chronic inflammation across the brain, immune system, and digestive system.

«We found that this pathway regulates not only IDO but also other important components of the immune system, suggesting that blocking this pathway may be superior to targeting IDO only,» Hanks said.

Pathway analysis also found changes in genes linked to the immune system, the body's inflammatory response, and cells» energy metabolism.

Loss of the PBRM1 gene function caused the cancer cells to have increased expression of other genes, including gene pathway known as IL6 / JAK - STAT 3, which are involved in immune system stimulation.

Poznansky's team — with lead scientist Huabiao Chen, PhD, corresponding author of the current report — had been investigating applications of AMD3100, a drug that blocks the CXCR4 / CXCR12 signaling pathway known to be involved in cancer development and in the way in which mesothelioma evades the immune system.

Durvalumab and tremelimumab are drugs in clinical development that block the PD - 1 / PD - L1 and CTLA - 4 pathways, respectively, and function to restimulate the immune system to target tumor cells.

Her work seeks to elucidate the mechanisms and pathways underlying the interaction between the immune system and cancer using mouse models that recapitulate the coevolution of tumor progression and the antitumor immune response.

The findings, based on a study of blood samples from a small number of women, suggests that the two conditions have similar underlying biochemistries marked by over activation of a part of the immune system called the alternative pathway of complement.

This and other studies suggest that DDT and the other pesticides may alter not only specific genes but also pathways of genes that collectively control the immune system or other systems that can be altered by chemicals.

Dr James Larkin, a Consultant Medical Oncologist at The Royal Marsden, London, UK, told the 2015 European Cancer Congress [1], that results from the CheckMate 067 phase III clinical trial had already shown that the combination of the two drugs, which target two different pathways that regulate the immune system, improved the progression - free survival in patients with melanoma who had not received any other treatment.

«Our team discovered an enzymatic pathway that converts omega -3-derived endocannabinoids into more potent anti-inflammatory molecules that predominantly bind to the receptors found in the immune system,» Das said.

Kim et al. suggest that moving away from empirical research to either systems analysis or hypothesis driven approaches may advance our vaccinology understanding.5 Interrogation of peripheral blood responses following vaccination, termed «systems vaccinology», has led to the identification of immune signatures and pathways that are correlated to immune responses.

As an Associate Professor at OSU, my research has been concentrated in the areas of aging, neuroimmunology, and neurotrauma.Overall, my research aim is to determine the degree to which the bi-directional communication between the brain and the immune system is affected by age, stress, and traumatic CNS injury and to delineate the mechanism by which inflammatory cytokine pathways cause long - lasting complications (e.g., cognitive decline and depression).

Dr. Levitsky: My organization within Roche, Pharma Research and Early Development (pRED), has invested in antibody engineering, not only for use of monoclonal antibodies in the established ways of delivering cell - killing agents to tumors or interrupting cell signalling pathways, but also as ways to engage and manipulate the immune system's response to tumors.

8.30 Hana Paculová CDK12 connects transcriptional regulation to DNA damage repair pathway 8.55 Karol Kaiser Wnt secretion during nervous system development 9.20 Simona Hankeová The role of Notch signaling in vasculogenesis 10.00 Coffee break 10.30 Tomáš Doležal Extracellular adenosine regulates complex host - pathogen interactions through the energy release for the immune response 10.55 Ondřej Bernatík and Igor Červenka Regulation of diverse function of Dvl by phosphorylation 11.20 Jan Ryneš Dissection of Axin interactome: rational approach for control of signaling cascades via intervention with specific protein - protein interactions 12.05 Targeting opportunities: discussion & sum - up 13.00 Lunch and departure

Topics covered will include how the immune system and commensal microbes interact in the context of health and disease; how dendritic cells respond to infectious or inflammatory stimuli and the roles they play in the induction and polarization of adaptive immune responses against pathogens; how the innate immune pathways regulate inflammation at mucosal barrier tissue sites and how the macrophages are involved in intestinal inflammation.

«Using a small molecule to significantly boost and overcome limitations of the TRAIL pathway appears to be a promising way to address difficult to treat cancers using a safe mechanism already used in those with a normal effective immune system.

Her research focuses on understanding how signaling pathways control gene expression, using T cells and other cells of the immune system as models.

Stimulation of the STING pathway appears essential to generate a de novo immune response comprising tumor cell death, generation of antigens, and activation of the innate and adaptive immune system.

The innate immune system is particularly amenable to characterization with expression - based methodology such as RNA - seq, as one of the key biological consequences of pathogenic infections is the rapid induction of several classes of effector proteins, along with up - regulation of a number of other pathway components.

There is also growing evidence that the protein - coding repertoire of the innate immune system is rapidly evolving in insects [5], [8]--[11], even though comparative genomic analysis reveals the existence of a conserved core of immune signaling pathways in most insects [12]--[15].

Also of wide impact have been Goldberg's studies showing that the ubiquitin proteasome pathway is critical in the clearance of misfolded proteins and in muscle atrophy in many disease states, as well as in antigen presentation to the immune system.

They linked these behaviors to immune pathways, implicating that targeting key components of the immune system could be a new therapeutic strategy for FTD.

Certain metabolites, such as fatty acids, ceramides and cholesterol crystals, elicit inflammatory responses through pathogen - sensing signalling pathways, implicating a maladaptation of macrophages and the innate immune system to elevated metabolic stress associated with overnutrition in modern societies.

In particular, we are interested in the contributions of the innate immune system, including the resident macrophage in the liver (Kupffer cells) and the complement pathway, in the initiation and progression of ethanol - induced liver injury.

• Disease - driving pathways that involve the human immune system are often targeted by antibodies, and Organ - Chips recreate complex interactions of different human cell types and aspects of the human immune system, overcoming limitations of animal models which do not reflect all human immune cells.

• New human - specific biomarker identification and new drug discovery is possible using Organ - Chips, based on new insights into biological pathways of disease and immune system interaction.

His studies are mainly focused on a classical innate immune pathway known as the OAS / RNase L system.