Genetic Vaccine Helps Immune System Researchers Dr. H. Kim Lyerly and Eli Gilboa from Duke University's Center for Genetic and Cellular Therapies in Durham, NC, are studying the safety and effectiveness of a new
immune system therapy called a genetic vaccine.
Treatment can include Polymodal therapy (polymodal nerve cells line the liver), immunomodulation (
immune system therapy), antioxidants, Vitamin E, Silibinin (stunts the growth of tumors), polyunsaturated phosphatidylcholine (fatty acid) or colchicine (derived from a plant).
Not exact matches
One setback for these
therapies which use the body's
immune system to fight cancers is that they are, at times, more effective in certain patient pools than others.
For example, we've seen new discoveries in health care recently, especially in immuno - oncology
therapies, which help the
immune systems of cancer patients recognize and destroy cancerous cells.
Massage
Therapy is delivered to improve the flow of blood and lymph (fluid in lymph glands, part of
immune system), to reduce muscular tension or flaccidity, to affect the nervous
system through stimulation or sedation, and to enhance tissue healing.
A randomized placebo - controlled trial of massage
therapy on the
immune system of preterm infants.
She will have a stronger
immune system, for instance, and will be much less likely to need orthodontia or speech
therapy.
Non-lactational mastitis occurs in women with weakened
immune systems, including women who have had lumpectomies with radiation
therapy and women with diabetes.
During the sessions, U.S. and Cuban scientists explored such topics as the molecular mechanisms cancer cells employ to evade the body's
immune system, new tools to image and manipulate that
system, and ways to rethink how such
therapies can best be deployed to reach patients where they receive health services.
A group of the nation's leading cancer research scientists and their Cuban counterparts are exploring how to advance cancer
therapy, diagnosis, and prevention, including the use of immunotherapy to harness the body's
immune systems to attack and eliminate cancer cells.
«This approach will hopefully lead to better mechanistic predictive modeling of response and future design of
therapies that further take advantage of how the
immune system recognizes tumors.»
Revving up the
immune system to combat a wide variety of tumor types may take cancer
therapy in a new direction, says Khaled Barakat, a computational scientist at the University of Alberta in Canada, who was not involved in the study.
A type of
immune therapy known as PD - 1 blockade controlled cancer in 77 percent of patients with defects in DNA mismatch repair — the
system cells use to spell - check and fix errors in DNA (SN Online: 10/7/15).
Side effects of the treatment included skin rashes, thyroid problems and diarrhea as the
therapy caused the
immune system to attack other parts of the body.
«If we know which genes are damaged in a breast cancer patient's
immune system, prevention or even
therapy can be tailored by giving vaccines or perhaps antiviral drugs to reduce the chances of recurrence,» said Friedenson.
Has anybody ever done anything like this — used gene
therapy to modify the
immune system?
«Current
therapies in clinical trials are focused on targeting genetic changes in tumors and helping to boost one's
immune system to fight the cancer cells.
More and more, Sweeney says, the
immune system is proving to be the most difficult hurdle in developing gene
therapy for humans.
The
therapy gives the
immune system the tools to flush out HIV, meaning daily drugs can be ditched — one man has been free of them for seven months
«Steep funding cuts for the federal health agencies are counterproductive at a time when innovative research is moving us closer to identifying solutions for rare diseases, new prevention strategies to protect Americans from deadly and costly conditions, advances in gene
therapy, new technologies for understanding the brain, and treatments that harness the ability of our
immune system to fight cancer.»
Patients with metastatic non-small cell lung cancer will always progress after chemotherapy, so most patients go on to be treated with immunotherapy, a type of
therapy that uses the body's
immune system to fight cancer.
«Our findings results suggest a new strategy for
immune system - based
therapies for cancer,» says the study's senior author, Harvey Cantor, MD, of Dana - Farber and Harvard.
«The findings also suggest that
therapies targeting the
immune system may be effective treatments against this disorder and possibly other forms of epilepsy,» said Nath.
Antibodies and T cells against the protein could cause the
immune system to attack cells carrying it, making gene
therapy ineffective.
For this study, researchers combined two
therapies, each targeting a different part of the
immune system.
Yet studies have shown single
therapies targeting only one part of the
immune system have been effective in only a small percentage of patients.
Treatments aimed at revving up the
immune system's attack on the cancer may be the most promising approach to cancer
therapy since combination chemotherapy.
«As a field, we are starting to grapple with premature aging in the HIV - infected population, even in patients who are on
therapy — their
immune systems largely look like someone whose
immune system is many years older,» Hunt notes.
And early stage startup Neochromosome, which includes Boeke, intends to raise money to design synthetic chromosomes for medicine that could be used in an off - the - shelf universal cell line in cell
therapies and transplants with minimal risk of rejection from the
immune system.
Their findings suggest that
therapies based on these compounds could help to treat rheumatoid arthritis, which occurs when the
immune system attacks the joints, causing pain and swelling.
«Our study reveals a new mechanism that could be harnessed for biological
therapies for lupus and other autoimmune diseases, where the
immune system mistakenly targets the body's own cells,» says senior study author Boris Reizis, PhD, professor of Pathology and Medicine at NYU Langone.
EMD Serono, Kirschbaum says, «focuses on the development of targeted cancer
therapies on three therapeutic platforms: targeting the tumor cell, the tumor environment, and the
immune system.»
Researchers are developing many different versions of CAR - T cell
therapies, but the basic premise is the same: Doctors remove a patient's T cells (
immune system cells that attack invaders) from a blood sample and genetically modify them to produce artificial proteins on their surfaces.
HIV also hides in cells and continues to undermine the host's
immune system despite antiretroviral
therapy that has improved the outlook of those with AIDS.
A phase 3 trial of lenalidomide / dexamethasone with elotuzumab (Empliciti ™), an antibody
therapy that attacks myeloma cells directly and spurs the
immune system to launch an attack of its own.
With additional genome tinkering to avoid rejection by the
immune system, they could be used clinically as a universal stem cell
therapy.
At the moment a lot of
therapies are focused on the site of infection or injury itself but this data suggests that it's the signals that are being sent out from the gut that are impacting the whole
immune system.
Dr. Cripe and his colleagues at The Ohio State University, the University of Pittsburgh School of Medicine and Cincinnati Children's Hospital Medical Center tested how well the oncolytic viral
therapy — a cancer - killing form of the herpes simplex virus, called oHSV — infected and killed tumor cells in mice with and without a healthy
immune system.
So he joined GSK Vaccines in 2010, as a molecular biologist in the company's Antigen - Specific Cancer Immunotherapeutic program, which aims to harness the
immune system for the development of well - tolerated cancer
therapies.
Stamets furnished capsules of freeze - dried fungus for a seven - year, NIH - funded study by Bastyr University and the University of Minnesota to determine whether turkey tail mushrooms could help breast cancer patients whose
immune systems had been compromised by radiation
therapy.
Much of the cancer - killing effect of the oHSV injections was lost when the researchers tested the
therapy in tumors of mice with defective
immune systems.
Participants also continued to take
immune system — modulating
therapies known to reduce symptoms.
Despite these promising clinical implications, the team calls for additional research on the interplay between viral
therapy, infectability and
immune system response.
Epigenetic
therapies are thought to work in two ways to fix these errors in cancer cells — by correcting the «position» of the gene switches and by making the cell appear as though it's infected by a virus, triggering the
immune system.
Viral
therapy for childhood cancer could possibly improve if treatments such as chemotherapy do not first suppress patients» immune systems, according to findings published today in the journal Molecular Therapy — Onco
therapy for childhood cancer could possibly improve if treatments such as chemotherapy do not first suppress patients»
immune systems, according to findings published today in the journal Molecular
Therapy — Onco
Therapy — Oncolytics.
According to Dr. Cripe, the study suggests that some patients could respond to
therapy even if their tumors aren't very infectable by the virus, provided their
immune systems were stimulated by the viral
therapy to attack the tumor cells.
Instead, the
therapy may benefit from the activity of the
immune system operating in tandem, creating a synergistic, cancer - killing effect.
Immune therapy for ovarian, breast and colorectal cancer — treatments that encourage the
immune system to attack cancer cells as the foreign invaders they are — has so far had limited success, primarily because the
immune system often can't destroy the cancer cells.
To help formulate effective
therapies against MRSA, researchers need a better understanding of how the
immune system can combat unyielding bacteria.
«We hope that this research showing GM - CSF is an important target will lead us toward
therapies that more effectively block the damaging
immune reaction in the central nervous
system of MS patients,» says Dr. Rostami.