Sentences with phrase «immune therapy»

Their discoveries have led to the development of effective immune therapies for several types of cancer.
Rates of dementia were lower in people who had been treated with immune therapies for arthritis, compared to those who had not.
In this webinar we will discuss the latest advances in mouse models for cancer research and how they are being applied to help us understand the pathways and mechanisms involved in new immune therapies.
Many groups around the world hope to use gene - editing to improve immune therapies for cancer.
Other immune therapies based on antibodies have also produced impressive outcomes in recent years.
Six patients were treated first with epigenetic therapy followed by immune therapy.
But if the researchers could teach T cells to target B cells specifically, perhaps immune therapy could do what chemotherapy could not.
But a new class of cancer therapy is going even further by combining targeted treatments with personalized immune therapy.
Hortense Dodo, a food molecular biologist on the team, says other attempts to solve the problem, such as immune therapy or vaccines, have failed so far (but see ScienceNOW, 10 March).
Important reports from the Weiner lab include the first DNA vaccine studied for HIV as well as for cancer immune therapy of cutaneous T cell lymphoma, the early development of DNA encoded genetic adjuvants, including IL - 12, advances in gene optimization, and advances in electroporation technologies resulting in improved gene delivery.
«We anticipate,» says Dr. Chou, «that this research will provide important pre-clinical data to support clinical trials using DAC and similar drugs combined with immune therapies targeting antigens like NY - ESO - 1 to treat advanced colorectal cancer and potentially other common cancers.»
In recent studies, about one - third of patients treated with immune therapies such as anti-CTLA4 or anti-PD1 respond, but the results vary widely.
Jedd Wolchok (Memorial Sloan - Kettering Cancer Center) and F. Stephen Hodi (Dana - Farber Cancer Institute,), in conjunction with scientists at Bristol - Myers Squibb Company, which had acquired Medarex, spearheaded an effort to devise new guidelines to assess patient benefit from immune therapies.
Weidhaas said that using the KRAS - variant and biomarkers like it to personalize radiation therapy as well as developing immune therapies for all cancer is very promising.
Purpose: The development of the UNC Immuno - Oncology Patient Centered Translational Research (IMPACT) Biorepository involves the collection of tumor tissue and blood, as well as data (e.g., demographic, clinical, questionnaire) from patients attending Oncology Clinics at UNC Hospital and undergoing immune therapy through participation in a Merck IT trial at UNC.
A new wave of potential immune therapies aims to target the network of complex sugars that coat cancer cells, Esther Landhuis reported in «Cancer's sweet cloak» (SN: 4/1/17, p. 24).
Muthumani's research interest is in the area of immune approaches to emerging infectious diseases and immune therapy approaches for the treatment cancer.
Cancer Center Director William Nelson said the institute would tackle some of the most pressing issues surrounding immune therapy: Why do only 20 to 30 percent of patients respond to the approach?
While combination chemotherapy is currently the treatment of choice, bone marrow transplants are available at select facilities and future treatment may include immune therapy with vaccines.
«We think that immune therapies work in cancers that have the most mutations and therefore have the most abnormal proteins being expressed that stimulate the immune system,» said Venook, the UCSF oncologist.
The company actually beat Wall Street profit estimates largely thanks to its superstar cancer immunotherapy drug Keytruda, which has been shown to best chemotherapy in helping lung cancer patients live longer and given Merck a leg up over rivals like Bristol - Myers Squibb's immune therapy Opdivo.
A type of immune therapy known as PD - 1 blockade controlled cancer in 77 percent of patients with defects in DNA mismatch repair — the system cells use to spell - check and fix errors in DNA (SN Online: 10/7/15).
The implication is that either immune therapies based on this approach will need to be implemented early in the course of the disease — before the tangles become resistant — or a multi-antibody approach that attacks both Ab and tau proteins will be necessary.
On the one hand, the treatment of rats after a stroke involves specific immune therapy, where so - called Nogo proteins are blocked with antibodies.
Physician Peter Bach at Memorial Sloan Kettering Cancer Center is appalled at the sky - high price of cancer treatments in the United States, and he is watching new immune therapies drive them higher still.
The researchers were able to reverse these epigenetic changes with the use of an FDA - approved drug, forcing the cancer cells out of hiding and potentially making them better targets for the same immune therapy that in the past may have failed.
«This would really strengthen the way clinicians can treat cancer using immune therapy, which holds so much promise for patients.»
«Scientists stimulate immune system, stop cancer growth: Anti-tumor immune therapy for colon cancer works in mice.»
Provide example data from experiments using PD - L1 positive tumors and a cancer cell - line engraftment into a humanized mouse model that was used to test anti-PD1 immune therapy
«New way to unmask melanoma cells to the immune system: Lab studies show promise for a clinical trial aimed at improving current immune therapies
Obese patients with metastatic melanoma who are treated with targeted or immune therapies live significantly longer than those with a normal body mass index (BMI), investigators report in a study published in Lancet Oncology of 1,918 patients in six independent clinical cohorts.
Though immune therapy and regenerative medicine are promising areas of research for future medical therapies, they are limited today by the difficulty of creating stem cells, and scientists around the world are searching for ways to create somatic stem cells in the easiest way possible.
Neoantigens are molecules on cell's surfaces that are produced by DNA mutations that are present in cancer cells but not in normal cells, making neoantigens ideal targets for immune therapy against cancer, say the scientists.
A special collaboration between UNC Linberger Comprehensive Cancer Center & Merck to advance immune therapy cancer research
«Although prior series have suggested that administering immune therapy to patients with autoimmune disease may be feasible, doing so conveys risk of disease exacerbation and requires careful monitoring.»
The long - term vision is to apply these technologies to other genetic diseases, such as sickle cell disease, and to explore applications in developing effective immune therapies for cancer.
University of Washington Fred Hutchinson Cancer Research Center Toward immune therapy for colon cancer: identification of antigens recognized by CD8 + T lymphocytes on colon cancer stem cells
The goal is to accelerate the development of breakthrough immune therapies capable of turning most cancers into curable diseases.
Our aim is to identify immunomodulatory mechanisms associated to the presence of the invading tumor in the LNs, and to discover biomarkers that could guide the design of patient - tailored immune therapies.
Novel immune therapies for prostate and pancreatic cancers, among others, are also in clinical study.
The team believes pairing a latency reversing agent, like Vorinostat, with an antiviral immune therapy, such as a vaccine or an antibody capable of recognizing and clearing the latent cells, will be needed to achieve a cure.
New epigenetic therapies, therapeutic viruses, novel nanoparticles and immune therapies look at external responses to cancerous growths — sequencing out mutations that can lead to cancerous growths; creating new pathogens that only attack cancer cells; building new particles that attack cancer cells; or boosting the ability of the body's natural immune system to attack cancer cells.
Worked in a Phase I / II clinical trials research laboratory that focuses on the development of antigen - specific cytotoxic T - lymphocytes for adoptive cellular immune therapies in children and adults
They are investigating other bacteria that could influence other immune therapies, such at the CTLA - 4 pathway, exploited by ipilimumab.
Another major focus of the Center is to generate new immune therapies for CANCER prevention or recurrence or for treatment.
Do not use this skinbooster on patients who are prone to hypertrophic scarring, who are undergoing immune therapy or have a history of autoimmune disease, who have inflammation or infection, or who have just had chemical peels, dermabration, or laser therapy.
The collaboration will explore the potential of various combinations of agents, including leveraging Immune Design's GLAASTM platform, with the goal to select the best potential immune therapy for patients.
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