Sentences with phrase «immune tolerance in»

If you notice the development of indentations (almost like small «holes») on this area, it may indicate a weaker immune tolerance in the lungs and higher susceptibility to infection including colds and respiratory issues.

Microchimerism is the presence of small populations of genetically disparate cells within a host as a result of transfusion or transplacental trafficking during pregnancy, and may influence immune tolerance in the recipient.

Made major contributions to the field of immunology through his studies on immune tolerance in animal models, with particular focus on transplantation tolerance and autoimmunity, in addition to pioneering the use of therapeutic monoclonal antibodies against T cells, resulting in the development of Campath - 1H, the first humanised monoclonal antibody to be used therapeutically.

Saturday, May 5, 6:00 PM, Ballroom D Jeffrey A. Bluestone Univ. of California, San Francisco Treg - mediated immune tolerance in health and disease

Jeffrey A. Bluestone Univ. of California, San Francisco Treg - mediated immune tolerance in health and disease

Inducing immune tolerance in people who have developed inhibitors is one approach.

Not exact matches

Different classes of MHC molecules exist and are involved in immunity against pathogens and tumor cells as well as the formation of immune tolerance to self - antigens.

Although immune tolerance can occur — in rare cases, transplant recipients who stop taking immunosuppressants have not rejected their foreign organs — researchers don't have a clear picture of what is happening at the molecular and cellular levels to allow this to happen.

Researchers infuse the patient with the organ donor's bone marrow in hopes that the donor's immune cells will teach the host to tolerate the transplant; donor immune cells that come along with the transplanted organ also, some contend, can teach tolerance.

One gene that controls this pathway, HDAC7, is known to be a key factor in immune tolerance and the new data strongly suggests exploring the possibility that drugs affecting HDAC7 function may serve as future therapeutics in PSC.

They examined oral tolerance, a state in which the immune system is trained to remain neutral to food and harmless bacteria.

The findings, published online in Nature Communications on July 7, support inducing immune tolerance as a viable strategy to achieve life - long transplant survival.

Better understanding of how immune tolerance is lost and regained could inform efforts toward establishing stronger and more durable phases of remission in autoimmune disease and toward preventing cancer recurrence.

While difficult to achieve, immune tolerance — in which a transplanted organ is accepted without long - term immunosuppression — can be induced in some patients.

In the new study, scientists built upon previous discoveries that a safe, non-reproducing vaccine strain of T. gondii could cure mice of several types of solid tumors, and identified which parasite proteins and which immunological pathways are required to break immune tolerance.

In contrast, lymphocytes in both types of endothelial cell grafts expressed higher levels of genes known to be involved in dampening the immune response and inducing self - tolerancIn contrast, lymphocytes in both types of endothelial cell grafts expressed higher levels of genes known to be involved in dampening the immune response and inducing self - tolerancin both types of endothelial cell grafts expressed higher levels of genes known to be involved in dampening the immune response and inducing self - tolerancin dampening the immune response and inducing self - tolerance.

An act of tolerance In 2006, Lillicrap demonstrated that a simple oral treatment could train the immune system not to produce inhibitors.

Currently, the use of the bacterium Listeria monocytogenes to break the immune tolerance of pancreatic tumors is being explored in clinical trials and T. gondii may be similarly useful.

One promising strategy in the fight against cancer is to use the body's own immune system to remove tumor cells, but due to a phenomenon called immune tolerance, the immune system has a difficult time identifying which cells to attack.

In the skin, for example, Rosenblum and colleagues have previously shown that Tregs help establish immune tolerance to healthy skin microbes in newborn mice, and these cells also secrete molecules that help with wound healing into adulthooIn the skin, for example, Rosenblum and colleagues have previously shown that Tregs help establish immune tolerance to healthy skin microbes in newborn mice, and these cells also secrete molecules that help with wound healing into adulthooin newborn mice, and these cells also secrete molecules that help with wound healing into adulthood.

Using infectious organisms to break tumor immune tolerance may be an excellent therapeutic option for treating cancer in the future.

«Although this seems like a big step in understanding an essential part of tolerance, there are things we still don't know such as how the immune system compensates for mistakes made during negative selection.»

They found that, while the grafts of undifferentiated iPS cells harbored large numbers of T cells of only a few specificities — indicating a robust immune response — those found in grafts of the two types of endothelial cells were more diverse, suggesting a more limited response associated with a phenomenon known as self - tolerance.

Possible biological explanations for the findings include changes in the immune tolerance of the embryo, whose full genome is not concordant with the recipient's.

Now, researchers at Washington University School of Medicine in St. Louis have found that a kind of tolerance - promoting immune cell appears in mice that carry a specific bacterium in their guts.

So he and Mellor teamed up to see whether tryptophan starvation might play a role in fetal immune tolerance.

The immune system has several strategies to prevent this, known as tolerance, and researchers at the Medical University of South Carolina (MUSC) have identified a novel checkpoint of peripheral tolerance, specifically in B cells.

The immune system has built - in tolerance mechanisms that harness itself from responding to benign foreign antigens beneficial to our system, like food.

«Typical food triggers creation of regulatory T cells: Researchers document how normal diet establishes immune tolerance conditions in the small intestine.»

When the tumor - fighting T cells are kept in check by inhibitory regulatory T cells, scientists speak of «peripheral immune tolerance.»

The study participants were injected under the skin with different doses of GAD or a placebo preparation in order to induce immune system tolerance to the beta cells.

«New key regulator of acquisition of immune tolerance to tumor cells in cancer patients.»

Although a person's tolerance to hypoxia (lack of oxygen) varies according to differences in innate physiology and physical conditioning, no one is immune.

A more thorough immune system swap in which the donor's immune cells virtually take over might better ensure long - term tolerance, according to transplant surgeon Tatsuo Kawai of Massachusetts General Hospital in Boston, a co-leader of the trial.

Together with the more studied regulatory T cells (Tr1 and CD25 + FOXP3 + Treg), growing evidence indicates that different subsets of dendritic cells (DC), play a critical role in promoting immune tolerance.

In this study, the researchers were able to block the autoimmune response by inducing immune tolerance to alpha - myosin.

Tolerance induction in the periphery is believed to be critical for the prevention of autoimmunity and maintenance of immune homeostasis.

This study relates to a big hurdle that needs to be overcome in order to better fight cancer: immune tolerance.

In the last decade, Foxp3 + Treg cells have raised the hope for novel cell - based therapies to achieve tolerance in clinical settings of unwanted immune responses such as autoimmunity and graft rejectioIn the last decade, Foxp3 + Treg cells have raised the hope for novel cell - based therapies to achieve tolerance in clinical settings of unwanted immune responses such as autoimmunity and graft rejectioin clinical settings of unwanted immune responses such as autoimmunity and graft rejection.

Since the liver plays a key role in inducing immune tolerance, that protein increases the production of regulatory T cells, suppressing the immune system's attack on the body.

During exposure to food antigens or nonpathogenic microbes, inflammation is absent, which results in immune tolerance — the default response.

Identify the mechanisms of autoreactive T effector and T regulatory expansion in man that can be harnessed to maintain or re-instate self - immune tolerance.

«This progressive colonization is thought to be important for development of immune system tolerance... lack of such tolerance possibly leads to food allergies and chronic inflammation,» the researchers write in Proceedings of the National Academy of Sciences.

His lab has extensive experience evaluating and modulating T cell responses to tumors and viruses, including introducing genes into T cells to impart specificity and modulate function, designing strategies to overcome tolerance and enhance in vivo activity, and developing mouse models that more accurately model human immune responses to candidate vaccines.

The $ 144 million research effort is led by a consortium of 70 world leaders in immune tolerance from over 40 institutions around the globe.

A number of studies reported that HDAC inhibitors could suppress the immune response of T cells and reduce the severity of inflammation and, therefore, might be used to inhibit immune rejection or induce tolerance in organ transplantation and BMT (20 — 23).

Dr. Bluestone has spent over 35 years working as an immunologist interested in immune tolerance as it relates to autoimmunity and organ transplantation.

In the first mouse model of the progressive form of multiple sclerosis, nanoparticles that created immune tolerance to myelin prevented the development of progressive MS.

At least in theory, producing regulatory T cells could promote immune tolerance and prevent the body from rejecting newly transplanted cells.

IDO1 has been implicated in immune modulation through its ability to limit T cell function and engage mechanisms of immune tolerance, and as such preventing tumor rejection.