By Day 42,
immunized animals generated plasma Abeta antibodies that labeled Abeta plaques in human, AD transgenic mouse and vervet brains; bound Abeta1 - 7; and recognized monomeric and oligomeric Abeta but not full - length amyloid precursor protein nor its C - terminal fragments.
Molecular analysis of the VHH repertoires of two sets of
immunized animals showed that each neutralizing lineage was only observed following immunization, demonstrating that they were elicited de novo.
Cross-reactive NAbs against the more sensitive tier 1 viruses were also induced in all
the immunized animals, but heterologous neutralization of tier 2 viruses was seen only weakly and sporadically.
-- Hyperimmune globulin, prepared by purifying and concentrating plasma of
immunized animals or previously infected humans with high titers (concentrations) of neutralizing antibody against Ebola virus, which have been shown to be protective in monkeys but are not currently available and would not be expected before mid-2015.
All of
the immunized animals were protected from infection when later exposed to chikungunya virus.
When Sanchez later injected the vaccinated guinea pigs with lethal amounts of live Ebola, none of the effectively
immunized animals became sick or died.
Protecting amphibians against chytrid may be tricky, if not impossible — attempts to
immunize the animals would last only a single generation, and fungicides could kill beneficial types and have other unintended consequences.
Additional vaccine doses in
an immunized animal do not increase or improve the immunity, but they do increase the risks.
Their job includes
immunizing animals to prevent them from disease, diagnosing animals to prevent any disease, and perform surgery on any part of their bodies.
Not exact matches
Now scientists report their first success in boosting these protective powers in large
animals: The first milk of cows vaccinated while pregnant temporarily
immunizes calves against bovine rotavirus, a serious threat to young farm
animals.
Forty days later, the tumors in the
immunized mice were one - tenth the size of those in the
animals that did not get the vaccine.
(Right) Autologous tier 2 serum NAb titers (IC50) in 50
animals immunized with various uncleaved gp140 proteins, compared to titers in the 30 rabbits given the BG505 or B41 SOSIP.664 trimers described here (see legend of Fig. 2 in the full article for details; P < 0.0001, two - tailed Mann - Whitney test).
Autologous tier 2 NAb responses in
animals immunized with native - like (SOSIP.664) trimers or non-native uncleaved gp140s.
Examination of brain homogenates from
immunized TG mice revealed no effect on monomeric human AS as compared with vehicle - treated
animals, but a 45 % reduction in oligomeric AS and a trend toward reduction of human AS dimers.
The finding of a Th -2-type pathology in our studies in
animals immunized with an rDNA - produced S protein is unequivocal.
Animals were administered 10 mg / kg of candidate mAbs weekly for 6 mo; control animals (WT and TG) were immunized with IgG1 as a cont
Animals were administered 10 mg / kg of candidate mAbs weekly for 6 mo; control
animals (WT and TG) were immunized with IgG1 as a cont
animals (WT and TG) were
immunized with IgG1 as a control Ab.
Additionally, splenocytes derived from transgenic
animals that had been
immunized with one or the other candidate did not activate an AS - specific T - cell reaction following in vitro stimulation with AS or the candidate antigens themselves.
Abeta42 - immunoreactive plaques were detected in frontal cortex in 11 of the 13 control
animals, but not in six brain regions examined in each of the four
immunized vervets.
Immunizing transgenic PDAPP mice, which overexpress mutant APP and develop beta - amyloid deposition resembling plaques in Alzheimer's disease (AD), results in a decrease of amyloid burden when compared with non-treated transgenic
animals.
Annual vaccination for diseases caused by CDV, CPV2, FPLP and FeLV has not been shown to provide a level of immunity any different from the immunity in an
animal vaccinated and
immunized at an early age and challenged years later.
If my
animal is not currently
immunized against rabies, I hereby consent to the administration of a rabies immunization to my
animal at the time of the surgical procedure.
The
animal may be too young, too weak or not
immunized.
for inside the home and well loved companion
animals who are spayed or neutered, fully
immunized and whose owners are on a very limited income.
(a) a statement of exemption is issued by a veterinarian with respect to the
animal that sets out the reason why the
animal can not be
immunized or reimmunized; and
The intent of the confinement agreements between HHS / CDC and the importer is to ensure that inadequately
immunized dogs will be confined in such a way as to minimize the risk of exposing persons and other
animals especially dogs to rabies until the dogs are considered adequately
immunized against rabies.
All
animals who find their way into the shelter are
immunized, spayed or neutered.
In
animals, there have been no documented cases in North America of rabies in vaccinated, truly
immunized dogs and cats for two decades, although the disease still exists among wildlife and feral companion
animal species.
That's why North Shore
Animal League America Veterinarian, Dr. Christina Buchter is urging all doggy parents to make an appointment at their local veterinary center to
immunize their pooch this season.
The American
Animal Hospital Association Vaccination Guidelines give greater detail should you want to know more about
immunizing your dog.
Immunize comes in two forms, a chewable pellet and a paste, which is easier to administer to an
animal that isn't eating.
If one booster vaccination is administered, almost all
animals (95 percent) are
immunized for life.