Sentences with phrase «immunocompetent mice»

This study focuses on the engraftment of HPCs in immunocompetent mice and proposes a strategy that could exploit available human ES cell lines to improve organ transplantation.

To sidestep the shortcomings of currently used cancer models, the Salk team harnessed the power of lentiviral vectors to infect nondividing as well as dividing cells and ferry activated oncogenes into a small number of cells in adult, fully immunocompetent mice.

Although a number of groups have already looked at the engraftment of ES - derived HPCs in Rag2 − / − γc − / − mice, there are no reports on HPC engraftment in either syngeneic or allogenic immunocompetent mice.

This is the first time that in vitro generated HPCs were transplanted and used to establish long - term engraftment in allogeneic immunocompetent mice, resulting in the protection of donor type grafts from immunological rejection.

We chose this model because 1) it more closely recapitulates features of human pancreatic cancer than do s.c. - implanted tumors, 2) it can be used in immunocompetent mice to permit assessment of immune responses, and 3) the cells grow in vivo with predictable kinetics (34).

In striking contrast, wild - type LCMV Armstrong, from which these variants were generated, induces a potent CTL response in immunocompetent mice and the LCMV infection is rapidly cleared.

Such virus variants selectively suppress LCMV - specific CTL responses and cause persistent infections in immunocompetent mice.

Although a number of instances of successful long - term engraftment of ES - derived HPCs have been published, no data are available yet on engraftment of these cells in immunocompetent mice.

A combination of our current protocol with a myeloablative treatment approach might further improve HPC engraftment in immunocompetent mice.

These results reinforce our notion that the decrease in mixed chimerism in the immunocompetent mice, but not in the Rag2 − / − γc − / − mice, is likely due to competition for space by the recovering autologous bone marrow cells.

While T and B cell development was very low in the Rag2 − / − γc − / − mice, higher numbers of lymphocytes (but still lower than would be expected in bone marrow transplants) were identified in the immunocompetent mice.

In ongoing experiments, we are studying whether natural killer cells play a role in the engraftment of HPCs in immunocompetent mice.

While this difference was largely strain - dependent, it also reflected the fact that in the Rag2 − / − γc − / − mice hematopoietic space was greater than in the immunocompetent mice.