Sentences with phrase «immunocompromised mice»

"Immunocompromised mice" refers to mice that have a weakened immune system. This means their ability to defend against diseases and infections is reduced. Full definition
Delaney et al. [4] who have shown that cord blood - derived CD34 + cells cultured in StemSpan ™ medium with cytokines, on plates coated with Notch ligand, are expanded ex vivo while still maintaining their ability to engraft into immunocompromised mice.
Moreover, following transformation with H - Ras, these cells initiated tumor xenografts in immunocompromised mice with higher efficiency than their epithelial counterparts [5].
The tissue - engineered colonic organoids were transplanted into the kidney capsules of immunocompromised mice for six to 10 weeks.
«If you infect immunocompromised mice with Pseudomonas,» Blackwell reports, «they are dead in about 48 hours.»
In a separate study published online this week by the Proceedings of the National Academy of Sciences, they show, among other things, that classic vaccinia causes weight loss, skin lesions, and death in severely immunocompromised mice, while MVA does not — even if the dose was 1000 times higher than normal.
To make a model system, a piece of a human tumor is implanted and grown in several immunocompromised mice, then harvested, fragmented, and implanted again in a larger set of mice that are treated with a variety of drugs and drug combinations.
In contrast, the same cells transplanted to immunocompromised mice remained highly immunogenic; eight of ten are still eliminated when transplanted to wild - type mice (regressor clones).
By culturing cells in a fed - batch system with StemSpan ™ medium containing cytokines and UM171, expanded cells were found to successfully engraft and repopulate immunocompromised mice, with no disadvantage when compared to unmanipulated cells.
Furthermore, the transplantation and subsequent engraftment of 3D - cultured skeletal muscle tissue into the endogenous muscles of immunocompromised mice led to high levels of vascularization and maintained muscle functionality.
Moreover, treatment with clinically approved mast - cell stabilizing compounds inhibited both mast cell activation and vascular leakage, in normal as well as immunocompromised mice.
The epithelial stem cells, when implanted into immunocompromised mice, regenerated the different cell types of human skin and hair follicles, and even produced structurally recognizable hair shaft, raising the possibility that they may eventually enable hair regeneration in people.
The iPS cell - derived bone substitutes were implanted under the skin of immunocompromised mice.
As proof - of - principle of the potential efficacy, Zhang's team grew human ovarian tumors in immunocompromised mice, then injected short - interfering RNAs to block the tumors» growth using RNA interference against FAL1.
The team also looked at a different mouse model of CML, where human CML cells were transplanted into an immunocompromised mouse.
«So you have to transplant those tissues into an immunocompromised mouse.
To translate these findings into an in vivo setting, we performed a modification of the established in vivo spheroid - based angiogenesis assay35, by co-grafting HUVEC with WT or Tie2 - silenced BP in a gel matrix subcutaneously into immunocompromised mice.
The new iPS cells passed the standard tests for pluripotency: They formed tumors called teratomas when injected into immunocompromised mice, and they could differentiate into cells from the three main tissue types in the body, including neurons, muscle and gut epithelium.
Although the cells died within about seven to 10 days in mice with functioning immune systems, they survived and proliferated in the immunocompromised mice.
So a project that we have been wanting to do for some time is to reconstruct autoimmunity in an immunocompromised mouse by putting in the target cells (beta cells), the effector cells (the immune system) and the educating cells (thymic epithelia).
Using both wild - type and immunocompromised mice, we hope to elucidate the role of dengue - specific CD8 + and CD4 + T - cells against Zika.
As proof - of - principle of the potential efficacy, Zhang's team grew human ovarian tumors in immunocompromised mice, then injected short - interfering RNAs to block the tumors» growth using RNA interference againstFAL1.
He injected them into immunocompromised mice, where they specialized into the body's main cell types, as the mouse iPS cells had done earlier.
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