Moreover, following transformation with H - Ras, these cells initiated tumor xenografts in
immunocompromised mice with higher efficiency than their epithelial counterparts [5].
«If you infect
immunocompromised mice with Pseudomonas,» Blackwell reports, «they are dead in about 48 hours.»
Not exact matches
Because
mice with intact immune systems are resistant to S. stercoralis infection, the researchers began
with an
immunocompromised strain of
mice, and then exposed some to a synthetic steroid called methylprednisolone (MPA) that is commonly used to treat asthma in humans.
To translate these findings into an in vivo setting, we performed a modification of the established in vivo spheroid - based angiogenesis assay35, by co-grafting HUVEC
with WT or Tie2 - silenced BP in a gel matrix subcutaneously into
immunocompromised mice.
Delaney et al. [4] who have shown that cord blood - derived CD34 + cells cultured in StemSpan ™ medium
with cytokines, on plates coated
with Notch ligand, are expanded ex vivo while still maintaining their ability to engraft into
immunocompromised mice.
By culturing cells in a fed - batch system
with StemSpan ™ medium containing cytokines and UM171, expanded cells were found to successfully engraft and repopulate
immunocompromised mice,
with no disadvantage when compared to unmanipulated cells.
Moreover, treatment
with clinically approved mast - cell stabilizing compounds inhibited both mast cell activation and vascular leakage, in normal as well as
immunocompromised mice.