Sentences with phrase «immunodeficiency virus]»

Non-compliance in teenagers and young adults is particularly high, with around 40 - 50 % of adolescents and young adults not adhering to the therapy regimen in Europe and the USA.xix Research into long - acting anti-retroviral therapy represents an exciting opportunity to tackle these issues and reduce the global burden of HIV related secondary immunodeficiency.

Superior efficacy of a human immunodeficiency virus vaccine combined with antiretroviral prevention in simian - human immunodeficiency virus - challenged nonhuman primates.

This is of limited use in chronic conditions such as organ transplantation or HIV where the emphasis is on managing the condition to minimise immunodeficiency.

Separation and partial characterization of proteinases with substrate specificity for basic amino acids from human MOLT - 4 T lymphocytes: identification of those inhibited by variable - loop - V3 peptides of HIV - 1 (human immunodeficiency virus - 1) envelope glycoprotein

Results from a recent study show that novel vaccine combinations can provide partial protection against infection by Simian Immunodeficiency Virus (SIV) in rhesus monkeys.

The LVSCID clinical trial for X-linked severe combined immunodeficiency uses a lentiviral vector to insert a healthy copy of the IL2RG gene into blood cells.

Human immunodeficiency Virus (HIV) continues to be a major public health problem.

The BSI has published a policy briefing on immunodeficiency, a class of disorders that impair the immune system's ability to mount an appropriate defence.

Blood Systems Research Institute (BSRI) today announced a collaboration to more precisely and efficiently measure the human immunodeficiency virus (HIV) latent reservoir in clinical samples using the Panther system from Hologic, Inc. — a fully automated molecular diagnostics platform that provides test consolidation, random - access sample loading, and proven assay chemistry.

It is this cell type that is hit hardest by the virus, causing the typical immunodeficiency that characterizes AIDS.

Cells with similar characteristics accumulate during normal aging as well as in younger persons infected with human immunodeficiency virus, suggesting that the process of replicative senescence is not an artifact of cell culture but is also occurring in vivo.

Reporting in Nature Medicine this week, Philip Johnson, a professor of pediatrics at the University of Pennsylvania, in Philadelphia, and his colleagues managed to protect monkeys from infection with the simian immunodeficiency virus (SIV), the animal model that is closest to HIV, by shuttling a gene into their muscles that produces antibody - like molecules that work against SIV.

Gene therapy is currently offered for a small number of immunodeficiency conditions, but with further research it is hoped that the therapy can be offered to more patients in the coming years.

LA JOLLA — Imagine a single drug that could prevent human immunodeficiency virus (HIV) infection, treat patients who have already contracted HIV, and even remove all the dormant copies of the virus...

Guido Silvestri, MD, division chief of Microbiology and Immunology at the Yerkes Research Center at Emory, and several of his research colleagues performed the first hematopoietic stem cell transplantation in three rhesus macaques infected with a simian human immunodeficiency virus (SHIV).

In a person with an immunodeficiency disorder, one or more components of either the adaptive or innate immune response is impaired, resulting in the body being unable to effectively resolve infections or disease.

Her main area of research is in CVID (common variable immunodeficiency) and antibody deficiency which resulted in better understanding of this rare group of disorders.

A prospective study on the natural history of patients with profound combined immunodeficiency (P - CID): an interim analysis.

2012 — Novel Ad26MVA vaccine provides protection against SIV — Results found Ad26 / MVA vaccine combinations can provide partial protection against infection by Simian Immunodeficiency Virus (SIV) in rhesus monkeys.

Immunodeficiency disorders result in partial or full impairment of the immune system, leaving the patient unable to effectively resolve infections or disease.

Notably, in May 2016 the European Commission granted marketing authorization for Strimvelis for the treatment of ADA - SCID, a severe form of immunodeficiency.

Using enhanced DNA technology, the lab has designed DNA vaccines that drive immune responses in prophylactic or therapeutic settings against Human Immunodeficiency Virus (HIV), Dengue (DV), Chikungunya virus (CHIKV), Middle Eastern Respiratory Syndrome (MERS) virus, and Zika Virus (ZV).

Biological and functional characterization of bone marrow - derived mesenchymal stromal cells from patients affected by primary immunodeficiency.

Transfer of a functional human immune system to mice with severe combined immunodeficiency.

In essence, cytokine signalling through TYK2 for those carrying genetic markers for autoimmune diseases is low enough to protect against autoimmunity, but high enough to prevent immunodeficiency.

Other viruses, such as cytomegalovirus, herpes simplex virus types 1 and 2, varicella - zoster virus, human immunodeficiency virus, and chikungunya virus, have also been described to cause congenital malformations.16, 17

«Patients who develop granulomatous lymphocytic interstitial lung disease (GLILD) as a complication of common variable immunodeficiency (CVID) often have poorer outcomes.

The virus's long hibernation, which can last for decades in people with HIV (human immunodeficiency virus), appears to boost its ability to live and spread within people, researchers have now shown in a pair of studies published in Cell on Thursday.

In the 1970s, Wong - Staal worked in the field of retroviruses at the National Cancer Institute in Bethesda, Md., with researcher Robert Gallo, credited as the co-discoverer of the human immunodeficiency virus (HIV), the virus that causes AIDS.

• Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ≤ 1.5 times ULN) • Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN Exclusion Criteria: • Presence of active / uncontrolled central nervous system involvement • History of clinically significant cardiac disease; uncontrolled hypertension • Left ventricular ejection fraction (LVEF) < 45 % • Allogeneic stem cell transplant within 100 days before first dose of study drug • Known history of human immunodeficiency virus (HIV) infection • Chronic or active hepatitis B or C, requiring antiviral therapy • Evidence of history of bleeding disorder, dialysis, or coexisting cancer that is distinct in primary site or histology from the cancer evaluated in this study • Serious, uncontrolled infection • Unresolved chronic toxicity > grade 1 from prior therapy • Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of the study

IgA deficiency is one of the most common genetic immunodeficiency disorders in humans and is associated with an insufficiency or complete absence of the antibody IgA.

By means of a non-obese diabetic / severe combined immunodeficiency disease (NOD / SCID) xenotransplant assay in combination with specific cell surface markers (CD44 + CD24 - / low), CSCs were enriched from metastatic and primary breast tumors and were shown to have the ability to reestablish tumor heterogeneity after transplantation [1].

Researchers have found a receptor for human immunodeficiency virus (HIV) that appears to play a key role in the transmission of the virus between individuals.In the June 20, 1996, issue of Nature, a...

Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency.

Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus - based lentiviral vector system.

Immunodeficiency, Centromere region instability, Facial anomalies syndrome (ICF) is a rare autosomal recessive disease that damages the immune system.

LA JOLLA — For infants with severe combined immunodeficiency (SCID), something as simple as a common cold or ear infection can be fatal.

For the first time, researchers have peered deep inside the human immunodeficiency virus (HIV - 1) and described a fragment of the egg - like shell that envelops the virus» genetic material.

She is broadly interested in using computational techniques to model the in - host population dynamics of viral infections, and is particularly interested in modeling the interactions between Human Immunodeficiency Virus and the immune system.

Read about the St. Jude trial: LVXSCID - ND: Gene Transfer for X-Linked Severe Combined Immunodeficiency in Newly Diagnosed Infants

(a) Growth curves of primary tumors in non-obese diabetic / severe combined immunodeficiency disease (NOD / SCID) mice injected with 5 × 105 or 5 × 104 MDA - MB 231 and MDA - MB 231 F3 cells.

The first reports that gene - editing of bone marrow stem cells in monkeys infected with a variant of simian immunodeficiency virus (SIV) significantly reduces the number Read more about Gene - editing and vaccines could improve HIV treatment - Scimex

St. Jude has played a key role in vector development, pioneering innovative vector designs for patients with hemophilia and the devastating immune disorder X-linked severe combined immunodeficiency (SCID).

Cell - Mediated Immunity to Target the Persistent Human Immunodeficiency Virus Reservoir.

A team of researchers based partly in South Africa has identified a key set of immune system molecules that helps determine how effectively a person resists infection with human immunodeficiency...

This is in addition to the licensing of products such as GlaxoSmithKline's Strimvelis ex-vivo stem - cell therapy for treatment of severe combined immunodeficiency caused by adenosine deaminase deficiency (ADA - SCID) in 2016 (1)-- has led to an increase in demand for therapeutic vector manufacturing capabilities.

Dr. Verma and his Salk colleagues pioneered the use of a stripped - down version of the human immunodeficiency virus (HIV, the causative agent of AIDS) to carry genes into defective cells.

Visualization of human immunodeficiency virus protease inhibition using a novel Förster resonance energy transfer molecular probe.

Enfuvirtide (T - 20): a novel human immunodeficiency virus type 1 fusion inhibitor.

Bachelerie F. CXCL12 / CXCR4 - axis dysfunctions: Markers of the rare immunodeficiency disorder WHIM syndrome.