Sentences with phrase «immunodeficient mice»

To improve our understanding and to build better and more translatable in vivo mouse tumor models, we are developing humanized mouse models consisting of the transplant of patient - derived tumor xenografts into immunodeficient mice reconstituted with human immune cells (isolated from the matching patient from the draining LNs or with allogenic PBMCs or LN cells).

However, their initial finding demonstrated that progenitor derived from iPSCs generated using lentiviral gene transduction led to the high incidence of highly aggressive tumors in immunodeficient mice after transplantation under the kidney capsule.

Implementation of experimental procedures in cancerology and availability of 7 specialized laboratories of biosafety level BSL2 and BSL3, equipped with imaging (bioluminescence / fluorescence), surgery rooms with volatile anaesthesia, means of phenotypic characterization of immunodeficient mouse models, sensitization of murine tumours to radiotherapy and vectorized internal radiotherapy

In tests on human breast cancer cells and in special immunodeficient mice with tissue grafts, the scientists found that both agents interfered with genes involved with breast cancer cell growth, resulting in more cancer cells.

NOD.Cg - Rag1tm1Mom Prf1tm1Sdz / SzJ, a new immunodeficient mouse strain supporting enhanced human hematolymphoid cell engraftment.

The adult livers of immunodeficient mice support human hematopoiesis: evidence for a hepatic mast cell population that develops early in human ontogeny.

The research team found that injection of CAR T cells into 79 immunodeficient mice arrested the growth of GBM in 60 % of them.

In this study, the Hiroshima University researchers developed an animal model using severely immunodeficient mice whose livers were partially populated with human cells, in order to reconstruct elements of the human immune system.

To determine whether SOST impacts metastasis in animals, they modified a prostate cancer cell line to overexpress SOST, engrafted various cells lines onto immunodeficient mice, and quantified the rate of secondary tumors and of osteolytic bone lesions.

These conjugates were injected i.v. into immunodeficient mice bearing human KB tumors that overexpress the folic acid receptor.

Moreover, the iPS cells can spontaneously differentiate or be induced into various cell types of three embryonic germ layers in vitro and in vivo when they are injected into immunodeficient mice for teratoma formation.

A thousand myoendothelial cells transplanted into the injured skeletal muscle of immunodeficient mice produced, on average, 89 muscle fibers, compared with 9 and 5 muscle fibers for endothelial and satellite cells, respectively.

NSG ™ variants are the most highly immunodeficient mice and the models of choice for cancer xenograft modeling, stem cell...

«They displayed all the characteristics of cancer stem cells, and less than 100 and as few as 10 cells were enough to initiate a tumor when injected into immunodeficient mice,» says Friedmann - Morvinski.

There was scant experimental evidence for this hypothesis until 1994, when John Dick and colleagues demonstrated that leukemia - initiating stem cells (LSCs) present in the blood of leukemia patients may induce acute myelogenous leukemia (AML) when transplanted into severe combined immunodeficient mice (2).

The researchers also tested a Runx2 knock - down variant of a human multiple myeloma cell line and found that it produced significantly less tumor growth in immunodeficient mice than the original human multiple myeloma cells.

Comparison of human hematopoietic reconstitution in different strains of immunodeficient mice.

PDX models are created by implanting cancerous tissue from a human primary tumor directly into immunodeficient mouse or rat models, enabling acceleration of oncology research or drug discovery and development programs.

Infusion of CAR T cells into an immunodeficient mouse model led to inhibition of tumor growth.

Patient - derived xenographs involve the implantation of tumor tissue into an immunodeficient mouse which becomes an avatar to help identify which drug or drug combinations are most likely to be effective for an individual cancer patient.

Perhaps the most exciting observation occurred when fused IEC - 6 cells were transplanted into immunodeficient mice.

In subsequent tests using an immunodeficient mouse model infected by Zika, intravenous injections of sofosbuvir significantly reduced viral loads in blood serum compared to a placebo group.

When they mixed those cells with mouse follicular inductive dermal cells and grafted them onto the skin of immunodeficient mice, they produced functional human epidermis (the outermost layers of skin cells) and follicles structurally similar to human hair follicles.

In mouse models, carcinogen - induced tumors that arise in immunodeficient mice, when transplanted to wild - type mice, are usually eliminated by the intact immune system of the new host.

Presumably, tumors induced in immunodeficient mice are highly immunogenic, and therefore easily identified and removed by a healthy immune system.

Once seeded onto a proper support, these keratinocytes appeared capable of forming a pluristratified epidermis both in vitro and in vivo as xenografts in immunodeficient mice.

In immunodeficient mice, for example, carcinogen - induced tumors develop more often and progress more rapidly than in wildtype mice.

In athymic (nude) immunodeficient mice, pinworm infections may instigate lymphoproliferative disorders that may eventually lead to lymphoma.

Another study in the same issue of Nature also investigated cancer immunoediting in immunodeficient mice, this time in an oncogene - driven model of sarcoma.

They developed a simple system that allows them to transplant human hepatocytes into immunodeficient mice, which can now be used to test how drugs affect the liver.

Upon orthotopic transplantation into immunodeficient mice, these organoids form normal pancreatic ducts and acinar tissue resembling fetal human pancreas without evidence of tumour formation or transformation.

Immunohistochemical, cytogenetic and genetic analyses were performed on both the human biopsy and xenografted tumor from severe combined immunodeficient mice.

To directly examine whether ABL kinases play a role in regulating the colonization and survival of breast cancer cells in the bone microenvironment, we injected control or ABL1 / ABL2 knockdown breast cancer cells directly into the tibia of immunodeficient mice.

To investigate whether inhibition of ABL kinases interferes with metastatic processes other than invasion, we depleted ABL1 and ABL2 (ABL1 / ABL2) in two bone metastatic breast cancer cell lines, 1833 and SCP28 (22), and evaluated the metastatic potential of these cells after intracardiac injection into immunodeficient mice.

When injected into immunodeficient mice, the iPS cells grew into neural tissue, cartilage, muscle, and forebears of cells that line the intestinal tract — representing all classes of tissue that give rise to a complete body.

Responsible for the daily care and wellbeing of a wide variety of university research animals to include conventional and quarantine rats, clean mice, quarantine mice, BSL2 / immunodeficient mice, radiological rats and mice, hamsters, rabbits, BSL2 rabbits, ferrets, swine, and ground hogs