Sentences with word «immunogen»

Scientists in pursuit of an HIV vaccine are building on this work, designing techniques to elicit these antibodies through sequential stimulation of the immune system with specifically designed immunogens.

A Genome - Wide Proteome Array Reveals a Limited Set of Immunogens in Natural Infections of Humans and White - Footed Mice with Borrelia burgdorferi

Thus the GL VHH tested in this study which both bind the R2 immunogen and neutralize the corresponding virus were not present at t = 54 at detectable level by 454 sequencing and it is therefore likely that they were absent or extremely rare at t = 0.

The envelope glycoprotein (Env) trimer on the virus surface is the only bNAb target and accordingly serves as the basis for recombinant protein immunogens intended to induce bNAbs.

Jardine et al. used mice engineered to express germline - reverted heavy chains of a particular bNAb and immunized them with an Env - based immunogen designed to bind to precursors of that bNAb.

Thus, our findings indicate that native - like trimers represent a promising starting point for the further development of recombinant Env immunogens intended to broaden the NAb response.

The researchers injected the four cows with an HIV immunogen, a molecule that can prompt the HIV immune response.

«Repeated immunization of immunogens derived from the initial transmitted / founder virus and escape variants with higher binding ability to a bnAb lineage may be required to induce bnAbs.»

«She was so enthusiastic about that, and she told me: Maybe you could help to discover what is the main immunogen,» Victor recalls.

Boosting these animals with other immunogens may drive these antibodies to further mutate into the longsought bNAbs.

A major goal of HIV - 1 vaccine development is to identify immunogens capable of inducing protective titers of broadly neutralizing antibodies (bNAbs) against circulating, neutralization - resistant (tier 2) viruses.

This suggests that a pan-influenza vaccine may be possible, given the right immunogen.

For the published request for applications, see the May 18, 2016 Guide announcement, Partnerships for Structure - Based Design of Novel Immunogens for Vaccine Development (R01).

They can be used as immunogens to produce antibodies against specific regions of proteins, and this eliminates the need to purify native proteins.

Please note that the recommendations are based on immunogen sequence only we currently do not hold any rabbit specific data.

ǂ «A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen» by Impagliazzo et al. published in Science on Monday 24th August.

The peptide immunogen has been supplied to the Mains and Devi labs and they have raised similar antisera.

«Although cows are not humans, these data provide important insights on how the immune system responds to HIV [immunogens],» Barouchs did not take part in the research.

She coordinated the project NGIN «Next generation immunogens inducing broadly reactivity neutralising antibodies».

The first immunogens are those similar to the trimer outer Envelope protein of native HIV.

Once pieced together, researchers delivered this patchwork of immunogens into the body by using an adenovirus (Ad26).

A team of scientists led by NAC and IAVI researchers have already engineered a prototype immunogen — the active ingredient of a vaccine — based on insights gleaned from such studies.

Bacteria are potent immunogens because they express a number of factors that can act as immune stimulants.

«Then the ultimate proof of utility of this discovery is to use it to design immunogens that can induce broadly neutralizing antibodies by vaccination.»

This revealed that the antibodies were matured fully only in response to the protein immunogens.

Washington University Epitope - based immunogens and diagnostics for dengue virus

Paradoxically, it remains the case that even minimal mutation towards the J3 germ line V gene abolishes the ability to bind either immunogen used [26]; the reintroduction of the three germ line CDR2 residues renders the VHH incapable of binding Env.

In what some researchers are calling a «major advance,» three recently published research studies detail these advances and provide the first immunogenicity data in animals for two different types of immunogens.

«This alliance is working to determine, amongst many, many different sectors and companies, how do we come up with the best way to select these mutations and immunogens?»

Using the findings from this study, the team has designed vaccine immunogens to selectively trigger the cooperating antibody - producing B cells to cooperate to make broadly neutralizing antibodies in a manner that mimics broadly neutralizing antibody development in natural HIV infection.

Finally, the gels can carry pathogens or immunogens, which means that they are not suitable for growing organoids to be used in the clinic.

Immunogens are designed to elicit the production of highly coveted broadly neutralizing antibodies that protect against HIV - 1 [Also see Report by McGuire et al..]

A challenge for HIV - 1 immunogen design is the difficulty of inducing neutralizing antibodies (NAbs) against neutralization - resistant (tier 2) viruses that dominate human transmissions.

Interestingly, A14, B9 and B21 GL VHH (with the V gene reverted to germ line but mature DJ regions) were all able to bind the R2 immunogen and neutralize the homologous virus (Fig. 7) but only B21 GL could bind the both immunogens and neutralize both viruses.

This suggests the immunogens imposed constraints resulting in a common structural mode of high affinity encoded by different sequences.

GL B21 on the other hand bound to both immunogens (Fig. 7A, B) although to a lesser degree than B21 (Fig. 2A, B) which has additional mutations within the V gene.

Can we design immunogens to stimulate specific B cell lineages, effectively launching «specific» affinity maturation pathways that lead to broadly neutralizing anti-viral responses?

Dr. Schief's work focuses on computation - guided and structure - based design of immunogens and immunization regimens, with the goal of inducing broadly neutralizing antibodies against HIV and other pathogens that have frustrated traditional vaccine design strategies.

Antibodies against the immunogen can then be purified from the serum of the animal.