Immunogenicity refers to the ability of a substance to induce an immune response in the body. It means that when the substance enters the body, such as a vaccine or medication, it triggers the immune system to produce a response, typically by producing antibodies or activating immune cells. This immune response is important for protecting the body against harmful pathogens or diseases.
Full definition
iTeos» pipeline addresses key unmet needs in immuno - oncology: the inhibition of immune suppression in inflamed (hot) tumors and the increase of
immunogenicity in non-inflamed (cold) tumors.
Based on the
low immunogenicity of the HPCs in the mixed lymphocyte cultures, we now wondered whether the HPCs would engraft in allogenic recipients.
Researchers seek to sustain or increase this effect, and these clinical trials will enable them to collect more data and samples for
immunogenicity studies.
Male cats (n = 12) were divided into groups of three and were immunized once with 0 (sham), 50, 200, or 400 microg synthetic GnRH coupled to keyhole limpet hemocyanin and combined with a mycobacterial adjuvant to
enhance immunogenicity.
Safety and
immunogenicity analyses were based on intention - to - treat, such that all available data were included in analyses.
Another clinical study, RV306, began in September 2013 using the RV144 vaccine regimen to compare additional vaccine boosts and gather more
immunogenicity data in 360 new volunteers.
The vaccine is currently in pre-clinical development and is tested in a non-human primate study, so far with promising safety and
humoral immunogenicity data.
Thus, natural antibodies play a crucial role by preventing pathogen dissemination to vital organs and by
improving immunogenicity through enhanced antigen - trapping in secondary lymphoid organs.
«You really can't know what will have
more immunogenicity until they get into trials, and that's why we are testing them,» Fauci adds.
This is important as the
poor immunogenicity of these cells could be exploited for transplanting across MHC barriers with minimal conditioning of the host.
Following the RV144 trial, AFRIMS and MHRP initiated several follow - on clinical studies with Thai collaborators to conduct
intensive immunogenicity research related to RV144.
MHRP, which led the RV144 trial with the Thai Ministry of Public Health, initiated follow - on clinical studies to conduct intensive
immunogenicity research.
Her research utilises the immuno - SRM platform to detect tryptic peptides in dried blood spots and
predict immunogenicity to enzyme therapy in patients with infantile Pompe disease and other lysosomal storage diseases.
Diversity in oat
potential immunogenicity: basis for the selection of oat varieties with no toxicity in coeliac disease.
Both of the current studies2, 3 clearly show that intradermal vaccination may have
greater immunogenicity than intramuscular vaccination.
Researchers demonstrate that currently used systems assessments of human
iPSC immunogenicity are not sufficient.
Founded in 2014, ImmunXperts
provides immunogenicity and immune - oncology screening services, assessing all aspects of the immune responses in donors and patients, supporting its partners in the full development cycle of novel drugs, biotherapeutics and stem cell therapies.
In what some researchers are calling a «major advance,» three recently published research studies detail these advances and provide the
first immunogenicity data in animals for two different types of immunogens.
Therapeutic Potential for Toll - Like - Receptor 2 Agonists in Pediatric Acute Lymphoblastic Leukemia (pre-B ALL): Induction of Apoptosis and
Anti-ALL Immunogenicity.
However, their
strong immunogenicity precludes routine use in clinical transplantation due to the need for harsh preconditioning and the requirement for toxic immunosuppression to prevent rejection and graft - versus - host disease.
Besides
promoting immunogenicity of the thyroglobulin molecule, dietary iodine can enhance levels of reactive oxygen species (ROS), which lead to expression of cell adhesion molecules (ICAM - 1) that are crucial to the early phases of thyroid follicular inflammatory responses (3).
In theory, this approach could be used to predict
vaccine immunogenicity and reactogenicity in individuals early after vaccination.
Virally vectored TPA.BCA showed however
good immunogenicity and some efficacy in animal models.
As partner of TRANSVAC, IRTA will provide access to their animal facilities (CReSA) to carry out safety and
immunogenicity studies of new candidate vaccines and / or of novel vaccination (administration) strategies in pigs, ferrets and other large animal species.
The development process often takes 15 to 20 years or more and requires virus cultivation, animal model testing, product formulation,
immunogenicity testing and years of costly clinical trials.
She also investigated inhibition of DNA methylation and chemical induction of
immunogenicity in cancer cells in the laboratory of Professor Peter Dervan at the California Institute of Technology.
Phrases with «immunogenicity»