Not exact matches
White MT, Verity R, Griffin JT, et al.White MT, Verity R, Griffin JT, Asante KP, Owusu - Agyei S, Greenwood B, Drakeley C, Gesase S, Lusingu J, Ansong D, Adjei S, Agbenyega T, Ogutu B, Otieno L, Otieno W, Agnandji ST, Lell B, Kremsner P, Hoffman I, Martinson F, Kamthunzu P, Tinto H, Valea I, Sorgho H, Oneko M, Otieno K, Hamel MJ, Salim N, Mtoro A, Abdulla S, Aide P, Sacarlal J, Aponte JJ, Njuguna P, Marsh K, Bejon P, Riley EM, Ghani AC close, 2015,
Immunogenicity of the RTS, S / AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of
data from a phase 3 randomised controlled trial, Lancet Infectious Diseases, Vol: 15, ISSN: 1473 - 3099, Pages: 1450 - 1458
Researchers seek to sustain or increase this effect, and these clinical trials will enable them to collect more
data and samples for
immunogenicity studies.
CAMBRIDGE, Mass., April 27, 2017 — Moderna Therapeutics, a clinical stage biotechnology company that is pioneering messenger RNA (mRNA) Therapeutics ™ to create a new generation of transformative medicines for patients, today announced positive interim
data from an ongoing Phase 1 study of mRNA - 1440, an mRNA infectious disease vaccine against avian H10N8 influenza, demonstrating mRNA - 1440 induced high levels of
immunogenicity, and was safe and well tolerated.
In April 2017, Moderna published human
data for its mRNA vaccine technology in Molecular Therapy, which showed that its first prophylactic vaccine candidate, mRNA - 1440 — an mRNA prophylactic vaccine against avian H10N8 influenza — induced high levels of
immunogenicity and was safe and well tolerated.
Safety and
immunogenicity analyses were based on intention - to - treat, such that all available
data were included in analyses.
All available
data from all participants, including partial
data from participants lost to follow - up, were included in both safety and
immunogenicity analyses.
Moderna Announces Positive Interim Phase 1 Clinical
Data Demonstrating First mRNA Vaccine Candidate, mRNA - 1440, Induces High Levels of
Immunogenicity
WRAIR and collaborators will share
data related to assays designed to measure antibody responses following vaccination with ZPIV, biologic samples generated during the performance of animal studies, and biologic samples generated during the performance of early human trials assessing the safety and
immunogenicity of ZPIV.
Glenda Gray, executive director of the Wits Health Consortium's perinatal HIV research unit in South Africa, presented
data today at the HIV R4P conference in Cape Town indicating that the prime - boost vaccine candidates initially tested in the RV144 trial in Thailand — the only HIV vaccine trial to date to show any efficacy — induced cross-clade immune responses in a Phase I safety trial conducted in South Africa, with
immunogenicity similar to or greater than that of the responses induced in Thai volunteers.