Sentences with phrase «immunogenicity in»

-- «Mammaglobin — A Immunogenicity in Canine Mammary Cancer Vaccine Development,» led by Dr. R. Curtis Bird, Department of Pathobiology.

Prior to FibroGen, Dr. Kang investigated inhibition of DNA methylation and chemical induction of immunogenicity in cancer cells in the laboratory of Professor Peter Dervan, completing her PhD at the California Institute of Technology.

Although NY - ESO - 1 was isolated from an esophageal carcinoma patient, its expression in this type of cancer and its immunogenicity in esophageal cancer patients have not yet been fully elucidated.

Finding comparable safety and immunogenicity in U.S. and Ugandan populations provided proof of principle that a protective, multivalent filovirus vaccine is attainable.

iTeos» pipeline addresses key unmet needs in immuno - oncology: the inhibition of immune suppression in inflamed (hot) tumors and the increase of immunogenicity in non-inflamed (cold) tumors.

mRNA - 1440 demonstrated strong efficacy based Hemagglutination Inhibition Assay (HAI) and Microneutralization Assay (MN) titers, two measures of immunogenicity in response to vaccination, and was safe and well - tolerated.

The clinical research center CAIMED, part of Ponce Health Sciences University in Puerto Rico, will examine the vaccine's safety and immunogenicity in participants who have already been naturally exposed to Zika or dengue viruses

Selected mucosal vaccine candidates will be tested for immunogenicity in mice.

The next steps for this vaccine are to produce a clinical grade lot and conduct a phase 1 study of safety and immunogenicity in infants, Moore says.

Not exact matches

Diversity in oat potential immunogenicity: basis for the selection of oat varieties with no toxicity in coeliac disease.

Although Tdap has an excellent safety record, future cohort or surveillance studies must continue to assess safety and immunogenicity of Tdap immunization during pregnancy, write Natalia Jimnez - Truque, M.S.C.I., Ph.D., and Kathryn M. Edwards, M.D., of Vanderbilt University Medical Center, Nashville, Tenn., in an accompanying editorial.

According to Dr Won Park, Inha University Hospital, Korea, and lead investigator of the PLANETAS study, «the challenge for biosimilars is to demonstrate similarity in therapeutic effectiveness, safety and immunogenicity to their reference product, not just biochemical and pharmacokinetic equivalence.»

The study, which was published in the last issue of Science Translational Medicine, reports early plasma cytokine signatures that correlate with, and predict, the immunogenicity and reactogenicity of the vaccine.

The European research collaboration behind this study focuses on deep immunological analysis of the immunogenicity and reactogenicity of the Ebola vaccine in healthy volunteers.

Thus, natural antibodies play a crucial role by preventing pathogen dissemination to vital organs and by improving immunogenicity through enhanced antigen - trapping in secondary lymphoid organs.

The Transcriptomics Core Facility supports a systems biology approach in vaccine development focusing on the identification of transcriptomic correlates of vaccine immunogenicity and efficacy for a range of novel and licensed vaccines using PBMC or whole - blood and BAL fluid samples.

A Phase I evaluation of the safety and immunogenicity of vaccination with recombinant gp160 in patients with early human immunodeficiency virus infection.

Comparable antigenicity and immunogenicity of oligomeric forms of a novel, acute HIV - 1 subtype C gp145 envelope for use in preclinical and clinical vaccine research, doi: 10.1128 / JVI.00412 - 15, J Virol.

We produce live and inactivated viruses in our BSL2 and BSL3 facilities, and perform immunogenicity and efficacy studies in pigs (influenza) and sheep (RSV) with a focus on skin vaccination and extended monitoring of humoral and cellular immune responses in the blood and lung.

The Walter Reed Army Institute of Research (WRAIR) began vaccinations today in a Phase 1 human clinical trial to test the safety and immunogenicity of the Zika purified inactivated virus (ZPIV) vaccine.

Founded in 2014, ImmunXperts provides immunogenicity and immune - oncology screening services, assessing all aspects of the immune responses in donors and patients, supporting its partners in the full development cycle of novel drugs, biotherapeutics and stem cell therapies.

Using JanusMatrix, we have identified T cell epitopes in H7N9 influenza HA protein that are highly conserved with human genome epitopes, and these epitopes possess low immunogenicity, activate natural Tregs and suppress bystander effector T cell responses in vitro.

In April 2017, Moderna published human data for its mRNA vaccine technology in Molecular Therapy, which showed that its first prophylactic vaccine candidate, mRNA - 1440 — an mRNA prophylactic vaccine against avian H10N8 influenza — induced high levels of immunogenicity and was safe and well tolerateIn April 2017, Moderna published human data for its mRNA vaccine technology in Molecular Therapy, which showed that its first prophylactic vaccine candidate, mRNA - 1440 — an mRNA prophylactic vaccine against avian H10N8 influenza — induced high levels of immunogenicity and was safe and well toleratein Molecular Therapy, which showed that its first prophylactic vaccine candidate, mRNA - 1440 — an mRNA prophylactic vaccine against avian H10N8 influenza — induced high levels of immunogenicity and was safe and well tolerated.

One hundred children aged 1 to 6 years were sequentially assigned to 3 cohorts of 20, 40 and 40 participants with stratification for age by 2 - year increments (1 — 2 years, 3 — 4 years, and 5 — 6 years) to ensure that the study groups were balanced by age in case of age - related differences in tolerability or immunogenicity.

Vaccine studies in infants < 6 mo with novel vaccine candidates have generally demonstrated poor immunogenicity (90).

Citation: Thera MA, Doumbo OK, Coulibaly D, Laurens MB, Kone AK, Guindo AB, et al. (2010) Safety and Immunogenicity of an AMA1 Malaria Vaccine in Malian Children: Results of a Phase 1 Randomized Controlled Trial.

One secondary outcome will be immunogenicity, meaning monitoring subjects for any emergence of antibodies against the infused therapeutic antibodies themselves; additionally, «Multiple clinical and exploratory biomarkers will be assessed» in the Phase Ib trial.

The vaccines were evaluated for immunogenicity and efficacy; however, because of the previous report of immunopathology on challenge of ferrets and nonhuman primates that had been vaccinated with a whole virus adjuvanted vaccine and mice that had been vaccinated with a VLP vaccine, the primary orientation was to assess for immunopathology among animals in relation to type of vaccine, dosage, serum antibody responses, and virus infection.

Virally vectored TPA.BCA showed however good immunogenicity and some efficacy in animal models.

Safety and immunogenicity analyses were based on intention - to - treat, such that all available data were included in analyses.

Novel antigens were identified and proved very promising with good immunogenicity and also some efficacy in animal models.

All available data from all participants, including partial data from participants lost to follow - up, were included in both safety and immunogenicity analyses.

A phase Ib clinical trial in age deescalating population will be performed to assess safety and immunogenicity.

RV 172: A Phase I / II Clinical Trial to Evaluate the Safety and Immunogenicity of a Multiclade HIV - 1 DNA Plasmid Vaccine, VRC - HIVDNA016 -00-VP, Boosted by a Multiclade HIV - 1 Recombinant ADENOVIRUS - 5 Vector Vaccine, VRC - HIVADV014 -00-VP in HIV Uninfected Adu

The U.S. Military HIV Research Program (MHRP) at the Walter Reed Army Institute of Research (WRAIR) initiated a Phase 2 clinical trial to evaluate the safety and immunogenicity of a prime - boost Ebola vaccine regimen in both healthy and HIV - infected volunteers.

Therapeutic Potential for Toll - Like - Receptor 2 Agonists in Pediatric Acute Lymphoblastic Leukemia (pre-B ALL): Induction of Apoptosis and Anti-ALL Immunogenicity.

Within the framework of TRANSVAC2, the HZI will offer access in the form of pre-clinical studies in the murine system to assess the immunogenicity, safety and efficacy of specific vaccine formulations.

As partner of TRANSVAC, IRTA will provide access to their animal facilities (CReSA) to carry out safety and immunogenicity studies of new candidate vaccines and / or of novel vaccination (administration) strategies in pigs, ferrets and other large animal species.

HESC have been shown to have reduced immunogenicity, expressing low levels of MHC - I and MHC - II in both the undifferentiated and dedifferentiated state, and to possess an adaptive mechanism to immune responses [60]--[62].

Immunogenicity of ALVAC - HIV (vCP1521) and AIDSVAX B / E Prime Boost Vaccination in RV144, Thai Phase III HIV Vaccine Trial

Glenda Gray, executive director of the Wits Health Consortium's perinatal HIV research unit in South Africa, presented data today at the HIV R4P conference in Cape Town indicating that the prime - boost vaccine candidates initially tested in the RV144 trial in Thailand — the only HIV vaccine trial to date to show any efficacy — induced cross-clade immune responses in a Phase I safety trial conducted in South Africa, with immunogenicity similar to or greater than that of the responses induced in Thai volunteers.

Immunogenicity and efficacy studies in pig (influenza) and sheep (RSV) with a focus on skin vaccination and extended monitoring of humoral and cellular immune responses in the blood and lung.

PFIE will provide access to its facilities for immunogenicity and efficacy studies in pigs or sheep (as well as other species if needed), according to users» requirements.

Based on the low immunogenicity of the HPCs in the mixed lymphocyte cultures, we now wondered whether the HPCs would engraft in allogenic recipients.

In addition to the high degree of pluripotency, ES cells can generate newly - differentiated cells that appear to have low immunogenicity, an ideal property for allogenic transplantation.

Furthermore serum samples or immune Ig preparations generated in the context of immunogenicity and challenge studies performed under the umbrella of the «Animal Models» could be analysed.

As partner of TRANSVAC2, WBVR will provide access to their animal facilities (Lelystad) to carry out immunogenicity and efficacy studies of new candidate vaccines and / or of novel vaccination (administration) strategies in pigs, cattle, ferrets or other animal species.

Within the framework of TRANSVAC2, the HZI will offer access in the form of pre-clinical studies in the murine system to assess the immunogenicity, safety and efficacy of specific vaccine formulations containing a mucosal adjuvant.

SSI offers vaccination studies in mice including 1 - 2 control groups and full immunogenicity analysis including CMI and humoral immunogenicity using Flow cytometry (B and T cells) and ELISA (cytokines and antibodies).

In recent years, key improvements to existing vectors such as those based on adenovirus have led to significant improvements in immunogenicity and efficacIn recent years, key improvements to existing vectors such as those based on adenovirus have led to significant improvements in immunogenicity and efficacin immunogenicity and efficacy.