Sentences with phrase «immunoglobulin gene»

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family.

Brinster RL, Ritchie KA, Hammer RE, O'Brien RL, Arp B, Storb U. Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice.

The mouse heavy chain immunoglobulin gene contains a tissue - specific enhancer.

The structural analysis of a number of recombinants and the derivation of secondary recombination products define some of the basic features of the mechanism of immunoglobulin gene assembly.

DNA elements are asymmetrically joined during the site - specific recombination of kappa immunoglobulin genes

Two types of immature B cells, namely fetal liver hybridomas and the leukemic cell line 70Z / 3, both of which have cytoplasmic mu chains but no light chains, were examined for DNA rearrangements of their light chain and heavy chain immunoglobulin genes.

An octamer DNA sequence plays a critical role in directing transcription of immunoglobulin genes in B lymphocytes.

Susumu Tonegawa, Leroy Hood, and colleagues report on the organization of immunoglobulin genes, demonstrating how so many antibody patterns can be produced by such a limited number of genes.

Peters A, Storb U. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation.

The immunoglobulin genes that code for antibodies are highly rearranged in the genome, causing missed identifications of antibodies in mass spectrometry searches.

A surprising finding was a marked up - regulation of immunoglobulin genes in the knockout tumours.

Not exact matches

By using engineered zinc - finger nucleases (ZFNs) designed to target an integrated reporter and two endogenous rat genes, Immunoglobulin M (IgM) and Rab38, we demonstrate that a single injection of DNA or messenger RNA encoding ZFNs into the one - cell rat embryo leads to a high frequency of animals carrying 25 to 100 % disruption at the target locus.

Immunoglobulin K genes are constructed during lymphocyte differentiation by the joining of two DNA elements, VK and JK, to form both a VKJK coding unit and a reciprocal recombination product.

The gene (E2A) that codes for proteins with the properties of immunoglobulin enhancer binding factors E12 / E47 was mapped to chromosome region 19p13.2 - p 13.3, a site associated with nonrandom translocations in acute lymphoblastic leukemias.

But rather than delivering the entire gene for the clotting - factor proteins to cells, as most gene therapies do, the researchers used the viruses to engineer immune - regulating B cells to express a fragment of the clotting factor fused to an immune molecule called an immunoglobulin.

The results suggest that, although the lack of light chain synthesis can be due to a lack of gene rearrangement, there may also be transcriptional regulation, which may also be important for the expression of light chain immunoglobulins in immature B cells.

Janardan Pandey, Ph.D., an immunogeneticist specializing in immunoglobulin GM genes at the Medical University of South Carolina, helped monitor for immune responses that could limit the effectiveness of the broadly neutralizing antibody VRC01 in a phase 1 trial of that antibody in HIV - infected individuals led by a team at the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

Pandey's expertise as an immunogeneticist specializing in immunoglobulin GM genes was needed for the trial because the VRC01 antibody is built on the immunoglobulin GM3 platform.

Antibodies are generated through recombination of a fixed set of germline immunoglobulin segments, called V genes, with other germline immunoglobulin segments.

7.30 PM Gary Holland, MD: Interaction between Killer Immunoglobulin - like Receptor (KIR) Gene - HLA Combinations and Parasite Serotypes among Hispanic Individuals at Risk for Ocular Toxoplasmosis

Gross G, Waks T, Eshhar Z. Expression of immunoglobulin - T - cell receptor chimeric molecules as functional receptors with antibody - type specificity (chimeric genes / antibody variable region).

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre — loxP — mediated gene targeting.

Interaction between Killer Immunoglobulin - like Receptor (KIR) Gene - HLA Combinations and Parasite Serotypes among Hispanic Individuals at Risk for Ocular Toxoplasmosis

The zebrafish immunoglobulin zeta gene (ighz) and mouse Tcrd, which are proximal to the V gene array, are expressed earlier in development.

A variety of different mutations in the Immunoglobulin mu - binding protein 2 (Ighmbp2) gene have been identified to be the cause of SMARD, but the mechanism of how these mutations result in this disease are still unknown.

deCODE scientists have also located two additional genes with strong linkage to respiratory allergies, as measured by heightened immunoglobulin E (IgE) levels.

Detection of immunoglobulin heavy chain gene rearrangements in classic hodgkin lymphoma using commercially available BIOMED - 2 primers.

The antigen receptor genes that undergo rearrangements are the immunoglobulin heavy chain (IGH) and light chain loci (IGK and IGL) in B cells, and the T cell receptor gene loci (TRA, TRB, TRG and TRD) in T cells.

The laboratories also offer highly sensitive NGS - based MRD assays to track FLT3 mutations and patient - specific immunoglobulin and T - cell receptor gene rearrangements.

Recent studies in mice suggested that antibodies produced by old individuals may be encoded by distinct immunoglobulin (Ig) genes and that the somatic hypermutation process in these individuals is compromised.

Developing B cells use somatic hypermutation (SHM) to diversify their immunoglobulin (Ig) genes.

DT40 has with 1.3 × 10 − 5 mutations / bp / generation [14] a high and stable mutation rate at the immunoglobulin light chain locus, guaranteeing constant diversification of any gene cloned into this region.

Invivoscribe products identify clonal rearrangements within the immunoglobulin and T - cell receptor genes, which helps identify clonal B - and T - cell populations.

Developing B cells activate and diversify their immunoglobulin (Ig) genes by recombination, gene conversion (GC) and somatic hypermutation (SHM).

Although all seven genes in the interval are Idd10 candidates, we suggest the gene encoding the EWI immunoglobulin subfamily member EWI - 101 (Cd101) as the most likely Idd10 candidate because of the previously reported immune - associated properties of the human CD101 molecule.

However, an incomplete picture of canine (Canis lupus familiaris) immunoglobulin (IG) and T cell receptor (TR)- or antigen receptor (AR)- gene loci has restricted their utility.