Sentences with phrase «immunoglobulin molecules»

Here we report that HB1.F3 NSCs can be engineered to express and secrete functional full - length HER2 - specific human immunoglobulin molecules that can selectively bind to and inhibit the proliferation of HER2 - positive breast carcinoma cells.

Here we report, for the first time, that human NSCs can be genetically modified to secrete anti-HER2 immunoglobulin molecules.

You can think of them as the glue in immunoglobulin molecules, the warriors of the immune system.

Not exact matches

During this time, the intestinal epithelium (the boundary between intestinal tissues and the external environment) is still permeable to large molecules like immunoglobulins, which helps aid in absorption of these powerful maternal antibodies.

A viral epitope inserted into the complementarity - determining region 3 (CDR3) loop of the heavy chain of a self immunoglobulin (Ig) molecule was generated from the Ig context and was presented by I - Ed class II molecules to virus - specific, CD4 + T cells.

The researchers also found that treating the mice with a molecule called CTL - associated antigen - 4 immunoglobulin (CTLA4Ig) suppressed damage to liver cells infected with hepatitis B virus, suggesting that this might be a potential approach to treatment.

The apCAM's are members of the immunoglobulin class of cell adhesion molecules and resemble two neural cell adhesion molecules, NCAM and fasciclin II.

But rather than delivering the entire gene for the clotting - factor proteins to cells, as most gene therapies do, the researchers used the viruses to engineer immune - regulating B cells to express a fragment of the clotting factor fused to an immune molecule called an immunoglobulin.

The alterations in the pattern of G reactivity are consistent with the tissue - specific binding of molecules to the mouse immunoglobulin heavy chain enhancer.

They discovered that three 3 - immunoglobulin domains come together to form a trimer (so - called because it is made up of three molecules).

Antibodies are immunoglobulins, and the upper arms of these Y - shaped proteins are designed to bind specifically to another molecule.

Gross G, Waks T, Eshhar Z. Expression of immunoglobulin - T - cell receptor chimeric molecules as functional receptors with antibody - type specificity (chimeric genes / antibody variable region).

«Although molecules such as FcRn do function in the immune system, in that they transport immunoglobulin, they certainly don't present antigens to T cell receptors, the primary function of MHC proteins,» said Bjorkman.

Subsequently, Shatz and colleagues identified a receptor on neurons called PirB (paired immunoglobulin - like receptor B), through which MHC molecules normally delivered the «off» signal.

Other studies have shown that a family of proteins called 14 -3-3 are involved in learning along with interesting cell adhesion molecules of the integrin family and the immunoglobulin superfamily.

The membranes were incubated with mouse sera obtained 3 - 5 weeks after inoculation (1:200 dilution), followed by three wash steps for 15 min each and incubation for 1 - 2 h with peroxidase - conjugated sheep anti-mouse IgG (whole molecule) or goat anti-mouse polyvalent immunoglobulins (1:10,000 dilution)(Sigma - Aldrich).

The Ishizaka's received worldwide recognition in 1966 for their discovery of the IgE (immunoglobulin E) protein, a molecule that induces allergic reactions in the human body.

Although all seven genes in the interval are Idd10 candidates, we suggest the gene encoding the EWI immunoglobulin subfamily member EWI - 101 (Cd101) as the most likely Idd10 candidate because of the previously reported immune - associated properties of the human CD101 molecule.

We discovered a negative regulator for IL - 1R - TLR signaling, the single immunoglobulin IL - 1 receptor related molecule (SIGIRR).

Immune System Booster — The sulphur that is present within the Methylsulfonylmethane is what helps your dog's body with an enhanced production of immunoglobulins, the molecule boosting the immune system in the dog (and the human, too.)