Specific Clinical / Research Interest: Experimental neuropathology, neurodegenerative disorders, brain aging; Functional anatomy of the cerebral cortex, comparative neuroanatomy; Computer - assisted morphometry, stereology, microscopy; Magnetic resonance microscopy, functional brain imaging Current Students: Tuyen Nguyen (PhD) Postdoctoral Fellows: Camilla Butti, PhD, Timothy Rumbell PhD, Merina Varghese PhD Research Personnel: Bridget Wicinski, Daniel Dickstein Summary of Research Studies: Our research is directed towards the study of selective neuronal vulnerability in dementing illnesses using classical neuropathological as well as modern quantitative
immunohistochemical methods.
Immunohistochemical methods were used to assess protein expression in formalin - fixed, paraffin - embedded cell blocks from Karpas 299 and SU - DHL1 and in 31 ALK + ALCL tumors using methods described previously (21).
The ImmunoStar # 24505 5 - HT2C Receptor antiserum was quality control tested using standard
immunohistochemical methods.
The ImmunoStar 5HT 6 receptor antibody was quality control tested using standard
immunohistochemical methods.
In order to test the sensitivity and specificity of spectral histopathology, the RUB team compared SHP with classical
immunohistochemical methods, in which tumours are identified with the aid of fluorescent labels.
In their study «D - Serine and Serine Racemase are Localized to Neurons in the Adult Mouse and Human Forebrain,» the lab utilized SR deficient (SR - / --RRB- mice, which have < 15 % of normal D - serine levels, to validate and optimize a D - serine
immunohistochemical method.
Not exact matches
Protein expression levels of DDX3 analyzed by
immunohistochemical staining are also subjected to similar classification (see Materials and
Methods).
A few years later, Karl Deisseroth's lab developed CLARITY, which is a hydrogel - based
method that also allows antibody penetration for
immunohistochemical labeling in whole tissue (15).