An international group of researchers led by Professor Christoph Hess from the Department of Biomedicine at the University of Basel and University Hospital Basel have now found a structure that accounts for the rapid
immunologic memory of particular immune cells (CD8 + memory T cells): these important memory cells form multiple connections between mitochondria — the powerhouses of cells — and the endoplasmic reticulum, the site of protein production.
Vaccines
produce immunologic memory; however, circulating vaccine - specific antibodies and immune cells in horses can drop in concentration after a few months.
Annual core vaccinations help provide protection
through immunologic memory, the body's immune response against an infectious pathogen, which allows the horse's body to react more quickly after the immune system has been primed with an initial series of vaccines.
To
gain immunologic memory the body must be exposed to the agent once, to know it, and then a second time to remember it.
Antibody titers in this study population of dogs were likely a result of prior immunization combined with any natural exposure, and suggest that these dogs had
adequate immunologic memory, the mechanism that provides animals with protection from clinical disease upon natural viral challenge.
If that fails, Plummer says his lab still may be able to answer the question by looking at the man's T cells and analyzing whether they have
any immunologic memory of having see the new virus.
In terms of its function and effect,
immunologic memory is well understood — an individual remains healthy despite being exposed to the pathogen.
Research Interests:
Immunologic memory; memory T - cells; allograft rejection; transplantation; therapies for transplant recipients
That recommendation was based on a general knowledge of vaccinal immunity, especially the importance of
immunologic memory and on duration of protection after natural sub clinical or clinical infections as well as on limited studies we had performed with certain canine and feline vaccines.
Successful vaccination to most bacterial pathogens produces
an immunologic memory that remains for years, allowing an animal to develop a protective anamnestic (secondary) response when exposed to virulent organisms.