Sentences with phrase «immunological responses in»

What's more, IL - 33 and the DNA vaccine augmented immunological responses in both CD4 helper T cells and CD8 killer T cells, with a large proportion of CD8 killer T cells demonstrating a further improvement in the ability of DNA vaccines to drive the immune system to kill tumor cells in animals.

«The candidate vaccine prompted a robust immunological response in recipients and was very well tolerated,» noted VRC scientist Julie E. Ledgerwood, D.O., principal investigator of the trial.

Not exact matches

Loe said interim tumor and immunological response data are likely in FY H2 / 18 at the earliest.

«A second interim tumor response / immunological response update is expected later in FY Q4 / 17,» Loe indicated.

No observed local immunological response at cell level after five years of oats in adult coeliac disease.

Giving small feeds more frequently during illness may help to maximise nutrient absorption Vitamins and minerals Folate, zinc, iron, vitamin B12, vitamin A, and possibly other micro-nutrients are involved in intestinal mucosal renewal and / or a variety of immunological responses.

In addition to the damage that can be caused to an individual animal, «the presence of lead indirectly impacts upon the Griffon vulture population due to changes to bird behaviour, reduced reproductive success and lower immunological response,» the researcher concludes.

The group has characterized the immunological responses of a cohort of these so - called non-progressors — HIV - positive children in South Africa who contracted the infection from their mothers but who remain healthy.

She is investigating the role of glycosylated molecules in tumor progression and metastasis, tissue - and species - specific expression of lectin receptors that play a role in regulating host innate immune responses and inflammation, and the immunological mechanisms underlying chronic inflammation and cancer development.

Doing so assumes, he says, that the CLA's immunological responses will be as potent in people as they have been in lab animals.

Melanoma is a tumor that is recognized by the immunological system and mechanisms leading to an anti-tumor immune response of potential value in the adjuvant setting.

Thus, placental function appears to be affected differently for male or female offspring, potentially framing sex differences in metabolic, immunological, and inflammatory responses (186).

The results were even more auspicious when the investigators stratified vaccinated subjects by antibody responder status: subjects who successfully mounted an immunological response to the vaccine enjoyed statistically significant benefits as measured with the IGA, the two motor function subscales of the MDS - UPDRS, and the Parkinson's Disease Questionnaire (PDQ - 39) of quality of life (though not on the PD Non-Motor Symptoms Questionnaire (NMS - Quest / PD - NMS)-RRB-, while no benefit was observed in nonresponders on any scale (Table 1).

Better understanding of these factors is a major area of interest in the lab, with some of the specific projects including tissue - specificity of cis - regulatory variants in the GTEx data set, immune response eQTLs where genetic variants contribute to inter-individual response to immunological stimuli, and haplotypic epistasis between regulatory and coding variants.

Current studies focus mainly on two receptor systems - the mast cell surface receptor, FcεRI, and the receptor for epidermal growth factor that operate in immunological and cell proliferation responses.

Allergen will be combined with novel immunomodulators — both adjuvants and specific immunological targets implicated in allergic responses — to invoke depletion and deviation mechanisms of tolerance.

Therefore the group: i) characterizes the specificity of these antibody responses to identify relevant targets for a vaccine; ii) developes new approaches to test antibody responses; and iii) adoptes the immunological analysis in preclinical (in rabbits and macaques) and clinical vaccines studies to identify predictive signatures for the development and prioritization of new HIV - 1 vaccine candidates.

Two new NSG mouse models allow immunological dissection of graft - versus - host disease (GVHD) responses and in vivo testing of therapeutic agents targeting human CD4 T cells.

Mast cells play important roles in initial immunological responses as well as in the clearance of parasitic infections (9, 10, 31, 32).

In cases where tools do not exist to identify and quantify relevant immune responses, MVI engages research groups in developing and optimizing immunological assays to improve our ability to develop strong vaccine candidateIn cases where tools do not exist to identify and quantify relevant immune responses, MVI engages research groups in developing and optimizing immunological assays to improve our ability to develop strong vaccine candidatein developing and optimizing immunological assays to improve our ability to develop strong vaccine candidates.

Evidence is accumulating that DHEA may be effective as a treatment for the immunological abnormalities that arise in subjects with low circulating levels of this hormone, including the impaired immune response of older individuals and immune dysregulation in patients with chronic autoimmune disease.93

Immunologist Dr. Jean Dodds has also noted similar issues: «Beyond the immediate hypersensitivity (vaccine) reactions, other acute events tend to occur 24 to 72 hours afterward, or 7 to 45 days later in a delayed type immunological response.

In a separate vivo study, an herbal remedy containing Echinacea was applied to mice grafts to understand the immunological response (22).

The relations between independent predictor variables (measures of immunological and psychological function at entry to the trial, age of onset, and duration of illness) and dependent dichotomous outcome variables (self rated global outcome; presence or absence of caseness on the general health questionnaire at follow up; reduced or normal delayed responses to hypersensitivity skin test) were examined in separate logistic regression analyses.