The new immunomodulatory mechanism uncovered employing an in vivo mouse model suggests that iPSC - MSCs secreted immunomodulatory factors inhibit the cleavage of caspases and suppress T cell responses to promote an anti-inflammatory environment.
This new study suggests that iPSC - MSC - secreted factors modulate T cell responses by inhibiting the cleavage of caspases, in what represents a novel immunomodulatory mechanism [3].