Sentences with phrase «immunomodulatory mechanism»

Researchers studying the effects of iPSC - MSCs treatment in an in vivo mouse model discover a novel immunomodulatory mechanism involving caspase proteins

The new immunomodulatory mechanism uncovered employing an in vivo mouse model suggests that iPSC - MSCs secreted immunomodulatory factors inhibit the cleavage of caspases and suppress T cell responses to promote an anti-inflammatory environment.

This new study suggests that iPSC - MSC - secreted factors modulate T cell responses by inhibiting the cleavage of caspases, in what represents a novel immunomodulatory mechanism [3].

Our aim is to identify immunomodulatory mechanisms associated to the presence of the invading tumor in the LNs, and to discover biomarkers that could guide the design of patient - tailored immune therapies.

Not exact matches

The study is investigator led and has therefore focused on clinical need, targeting patients with progressive multiple sclerosis in whom most disability is incurred... The study also reports a predominant effect on neurodegenerative rather than inflammatory outcomes, suggesting a novel mechanism of action that might be suitable as combination treatment with immunomodulatory treatments... Further phase 3 studies to measure the effect of simvastatin on sustained disability, particularly in patients with non-relapsing secondary progressive and primary progressive multiple sclerosis, are clearly needed, but this trial represents a promising point from which to develop trials of progressive disease.»

The authors suggest the mechanism behind this effect is the immunomodulatory effect of antibiotics, and the disruption of the microorganisms (microbiome) in the gut caused by antibiotics which can lead to reduce immune responses.

Multiple classes of agent with distinct mechanisms of action are now available for the treatment of patients with relapsed and / or refractory multiple myeloma (RRMM), including immunomodulatory agents, proteasome inhibitors, histone deacetylase inhibitors and monoclonal antibodies.

2Research has proven these curcuminoids exert powerful health - promoting effects via 160 mechanisms and pathways in the body such as antioxidant, neuroprotective, immunomodulatory, anti-inflammatory, epigenetic, and adaptogenic properties.