Sentences with phrase «immunopathologies as»
In bacterial vaccines, the antigen causes the same immunopathology as the disease itself.
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They found that IL - 27 levels in infected lungs follow, with some delay, the level of virus: they peak as viral levels are starting to decline and come down when immunopathology has resolved.
Fahmy, who worked as a chemical engineer at DuPont for 5 years before doing a Ph.D. in immunopathology, had just explained the complex relationship between the lymphatic system and the circulatory system when a reporter interrupted him.
The concern for an occurrence of lung immunopathology on challenge of mice vaccinated with an inactivated virus vaccine, as reported by Haagmans, et al. for ferrets and nonhuman primates, was seen by us after challenge of mice vaccinated with a SARS VLP vaccine [20].
As indicated, two reports attributed the immunopathology to presence of the N protein in the vaccine; however, we found the same immunopathologic reaction in animals given S protein vaccine only, although it appeared to be of lesser intensity.
Those challenged animals exhibited infection similar to unvaccinated animals as well as Th2 - type immunopathology.
As indicated, strong animal model evidence indicates expression of the N protein by SARS - CoV vector vaccines can induce sensitization leading to a Th2 — type immunopathology with infection.
To be certain the Th2 type immunopathology was elicited by the S protein vaccine in our studies and in hopes a greater immune response would result from higher dosages of the vaccine and induce greater protection against infection as well as reduce or prevent the immunopathology, our experiment 2 used up to 9 µg of the S protein for immunization.
Dr. Sanfilippo received his BS and MS degrees in physics from Penn, his MD and PhD in immunology as an NIH Medical Scientist Training Program Fellow at Duke, and Pathology residency training at Duke, with Boards in Anatomic and Clinical Pathology, and Immunopathology.
At Duke he also served as Director of the Duke - VAMC Immunogenetics - Transplantation Laboratory, Director of the Duke Immunopathology Lab, and chief of the Renal and Transplant Pathology services.
The Sette lab's approach uses epitopes as specific probes to define the immune signatures associated with productive / protective immunity versus deficient immunity / immunopathology.