In later experiments, these findings were confirmed and the vaccine utilized by Haagmans, et al. was also shown to induce
the immunopathology in mice.
The immunopathology in all experiments in the present study occurred in the absence of detectable virus in lungs of mice two days after challenge with infectious virus.
Not exact matches
Having discovered the crucial role of IL - 27
in regulating
immunopathology, the researchers wondered whether this could be exploited for therapeutic purposes.
They found that IL - 27 levels
in infected lungs follow, with some delay, the level of virus: they peak as viral levels are starting to decline and come down when
immunopathology has resolved.
The scientists conclude that
in mice «well - timed treatment with rIL - 27 improved lung injury and accelerated recovery without affecting viral clearance» and continue «these data demonstrate that IL - 27 has a unique role
in controlling
immunopathology without impacting on host defense, and might therefore represent a promising candidate for immunomodulatory therapy of viral pneumonia.»
Fahmy, who worked as a chemical engineer at DuPont for 5 years before doing a Ph.D.
in immunopathology, had just explained the complex relationship between the lymphatic system and the circulatory system when a reporter interrupted him.
It was a rich and rewarding workplace for a novice, surrounded by people who were experts
in disparate aspects of tuberculosis research including clinical trials, epidemiology, and
immunopathology.
Taking advantage of infected patients, proprietary animal models of infection and new technological advances
in the field of static and dynamic imaging,
Immunopathology Unit tackles unresolved issues that include the means by which innate and adaptive immune cells traffic and function within the normal, cirrhotic or cancerous livers.
Dr. Lohman - Payne's area of research is viral
immunopathology, with special interest
in the impact of HIV exposure
in...
The scientific advisory board also includes Douglas Cole, MD, General Partner, Flagship Ventures; Kenneth Chien, MD, Ph.D., professor
in the Department of Cell and Molecular Biology and Department of Medicine at the Karolinska Institute, and visiting professor
in the Department of Stem Cell and Regenerative Biology, Harvard University.; David Liu, Ph.D., Professor of Chemistry and Chemical Biology at Harvard University, a Howard Hughes Medical Institute Investigator and a Senior Associate Member of the Broad Institute of Harvard and MIT; Douglas Melton, Ph.D., Thomas Dudley Cabot Professor
in the Natural Sciences at Harvard University and an Investigator of the Howard Hughes Medical Institute; Elizabeth Nabel, MD, President of the Brigham and Women's Hospital (BWH) and Professor of Medicine, Harvard Medical School; and Ulrich H. von Andrian, M.D., Mallinckrodt Professor of
Immunopathology at Harvard Medical School.
In an effort to determine whether an adjuvant that induced a bias for a Th1 - type response would protect and prevent the
immunopathology, we initiated an experiment where the DI PBS suspended vaccine was adjuvanted with Freund's complete adjuvant, a Th1 - type adjuvant.
Finally, a number of other studies of vaccines
in animal model systems have been reported but presence or absence of
immunopathology after challenge was not reported.
A summary of the SARS - CoV vaccine evaluations
in animal models (including the current report) that indicated an evaluation for
immunopathology after challenge is presented
in Table 2.
That lung disease exhibited the characteristics of a Th2 - type
immunopathology with eosinophils
in the lung sections suggesting hypersensitivity that was reminiscent of the descriptions of the Th2 - type immunopathologic reaction
in young children given an inactivated RSV vaccine and subsequently infected with naturally - occurring RSV [32]--[33].
Professor Emeritus Curtis Wilson, Jr., a world authority on the
immunopathology of kidney diseases, joined Scripps
in 1968.
As indicated, two reports attributed the
immunopathology to presence of the N protein
in the vaccine; however, we found the same immunopathologic reaction
in animals given S protein vaccine only, although it appeared to be of lesser intensity.
In this regard, animal model studies with FIPV in cats and RSV in mice have indicated that viral surface proteins may be the sensitizing protein of inactivated vaccines for immunopathology with infection [32], [45
In this regard, animal model studies with FIPV
in cats and RSV in mice have indicated that viral surface proteins may be the sensitizing protein of inactivated vaccines for immunopathology with infection [32], [45
in cats and RSV
in mice have indicated that viral surface proteins may be the sensitizing protein of inactivated vaccines for immunopathology with infection [32], [45
in mice have indicated that viral surface proteins may be the sensitizing protein of inactivated vaccines for
immunopathology with infection [32], [45].
The vaccines were evaluated for immunogenicity and efficacy; however, because of the previous report of
immunopathology on challenge of ferrets and nonhuman primates that had been vaccinated with a whole virus adjuvanted vaccine and mice that had been vaccinated with a VLP vaccine, the primary orientation was to assess for
immunopathology among animals
in relation to type of vaccine, dosage, serum antibody responses, and virus infection.
Nevertheless, the Th2 - type
immunopathology pattern was seen only
in animals given an inactivated vaccine earlier.
In contrast to our results, those studies did not find clear evidence of the Th2 type
immunopathology on challenge of mice given a vector vaccine for the S protein.
To be certain the Th2 type
immunopathology was elicited by the S protein vaccine
in our studies and
in hopes a greater immune response would result from higher dosages of the vaccine and induce greater protection against infection as well as reduce or prevent the
immunopathology, our experiment 2 used up to 9 µg of the S protein for immunization.
Histopathology seen
in animals given one of the SARS - CoV vaccines was uniformly a Th2 - type
immunopathology with prominent eosinophil infiltration, confirmed with special eosinophil stains.
While increased titers of serum antibody were induced and no virus was detected day two after challenge
in most animals, the Th2 - type
immunopathology occurred after challenge, and the
immunopathology seen earlier after vaccination with the DI whole virus vaccine was seen again.
Dr. Sanfilippo received his BS and MS degrees
in physics from Penn, his MD and PhD
in immunology as an NIH Medical Scientist Training Program Fellow at Duke, and Pathology residency training at Duke, with Boards
in Anatomic and Clinical Pathology, and
Immunopathology.
This may result
in immunopathology.
Neurogenic Inflammation — The Peripheral Nervous System's Role
in Host Defense and
Immunopathology.
In bacterial vaccines, the antigen causes the same
immunopathology as the disease itself.
Gastrointestinal inflammation is evident
in the dogs with non-specific dietary sensitivity In collaboration with researchers at the School of Veterinary Medicine in Hannover, Germany, and the University of Bristol, UK, WALTHAM investigated the morphology and immunopathology of the small and large intestine in dogs with non-specific dietary sensitivity (Zentek et al. 2002
in the dogs with non-specific dietary sensitivity
In collaboration with researchers at the School of Veterinary Medicine in Hannover, Germany, and the University of Bristol, UK, WALTHAM investigated the morphology and immunopathology of the small and large intestine in dogs with non-specific dietary sensitivity (Zentek et al. 2002
In collaboration with researchers at the School of Veterinary Medicine
in Hannover, Germany, and the University of Bristol, UK, WALTHAM investigated the morphology and immunopathology of the small and large intestine in dogs with non-specific dietary sensitivity (Zentek et al. 2002
in Hannover, Germany, and the University of Bristol, UK, WALTHAM investigated the morphology and
immunopathology of the small and large intestine
in dogs with non-specific dietary sensitivity (Zentek et al. 2002
in dogs with non-specific dietary sensitivity (Zentek et al. 2002).
Boston Emergency, Boston, MA Pathology Externship o Performed rounds
in autopsy, surgical pathology, hematopathology,
immunopathology and cytopathology