Sentences with phrase «immunoreactivity revealed»
Quantification of GFAP and Iba1 immunoreactivity revealed parallels in both mouse models in addition to distinct patterns of microglial activation.
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The most recent study report described in these same regions decreased tissue levels of 5 - HT and tryptophan hydroxylase, the synthesizing enzyme for serotonin, and no evidence of excessive serotonin degradation as assessed by levels of 5 - hydroxyindoleacetic acid (the main metabolite of serotonin) or ratios of 5 - hydroxyindoleacetic acid to serotonin.30 A recent article described a significant association between a decrease in medullary 5 - HT1A receptor immunoreactivity and specific SIDS risk factors, including tobacco smoking.40 These data confirm results from earlier studies in humans39, 41 and are also consistent with studies in piglets that revealed that postnatal exposure to nicotine decreases medullary 5 - HT1A receptor immunoreactivity.42 Animal studies have revealed that serotonergic neurons located in the medullary raphe and adjacent paragigantocellularis lateralis play important roles in many autonomic functions including the control of respiration, blood pressure, heart rate, thermoregulation, sleep and arousal, and upper airway patency.
These GFP - labeled fibers were, however, only a subset of the total gustatory innervation of the taste buds, as revealed by immunoreactivity for P2X3 (Fig. 3E).
Furthermore, in brains from APP transgenic mice conformation - specific antibodies have revealed the early appearance of intraneuronal fibrillar and oligomeric Aβ immunoreactivity, which declined as amyloid plaques appeared, and further became evident in the extracellular space [10].
The examination of the amyloid pathology with super-resolution microscopy permitted us to further reveal a clear separation of the subcellular location of Aβ - immunoreactivity from that of APP / CTFs.
Our microscopy studies at high magnification and high resolution have revealed a clear segregation between Aβ - immunoreactivity and that of APP and its C - terminal fragments (CTFs).
Subsequent post hoc analysis revealed significantly lower CD68 immunoreactivity in exercised relative to sedentary Grn − / − mice (* p < 0.05).