Sentences with word «immunoregulatory»

First proposed more than 20 years ago, the hygiene hypothesis suggested that societal efforts to reduce exposure to infectious microbes early in life have deprived the immune system of immunoregulatory stimulation necessary for protection against allergic disease (4).

In studies, mucopolysaccharides show anti-inflammatory and immunoregulatory effects on connective tissue diseases.

The immune checkpoint refers to a range of immunoregulatory pathways that enhance or moderate immune responses.

They focused on what is known as immunoregulatory checkpoints.

We will use functional studies combined with gene expression profiling to determine serological responses to the vaccine, enumerate responding T and B cell subsets, and validate the biological relevance of differential expression of genes involved in immunoregulatory and metabolic pathways.

Apart from their protective function, these peptides have also exhibited immunoregulatory abilities against several autoimmune diseases.

IDO is a key immunoregulatory enzyme in the metabolism of the essential amino acid tryptophan to kynurenine.

The newly described mechanism involving gastric immunoregulatory mononuclear phagocytes brings an improved understanding of the complex and dynamic interactions between H. pylori and its human host.

Some preliminary research also suggests that wormwood contains anti-inflammatory, anti-cancer, and immunoregulatory benefits as well (4).

These findings lead to the hypothesis that impaired immune responses in the elderly to infection or vaccination reflects dysregulation of immunoregulatory pathways and metabolic pathways, which work in concert to orchestrate an effective immune response in young healthy individuals.

In addition to sIgA, infants in the early postpartum period also lack CD14, an immunoregulatory protein normally present in the mature intestine.

In vitro experiments demonstrated an immunoregulatory function of transgenic PD - L1 overexpressing HSPCs.

We take a multidisciplinary approach to explore the mechanisms and evolution of stromal - mediated immune dysfunction in the tumour microenvironment and uncouple the immunoregulatory systems governing their suppressive function.