Sentences with phrase «immunosuppressive effects»

However, for GVHD, the use of MSCs is a double - edged sword, because the prevention of GVHD was associated with a high incidence of leukaemia relapse, which is the result of the non-specific immunosuppressive effect of MSCs on graft - versus - leukaemia 57, 58.

Last, CD34 + cells from T1D patients were pharmacologically treated to increase PD - L1 expression, and these modulated cells demonstrated an enhanced immunosuppressive effect in vitro.

Luznik and colleagues have sought the right balance by giving high doses of cyclophosphamide, a chemotherapy drug with immunosuppressive effects, shortly after transplantation.

Both cigarette smoke and nicotine have been shown to inhibit pulmonary T cell responses, including secretion of IFNγ, and enhance susceptibility to virus infection [31, 33], which suggests that exposure to nicotine, such as in E-cigs, may exhibit immunosuppressive effects.

This has both anti-inflammatory and immunosuppressive effects by supplying vital oxygen and energy to every cell.

Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals.

Anna M.C.M. Doedée «Interaction of paracetamol with the immune system: immunosuppressive effects in human vaccination model» Promotor: Prof. dr. H. van Loveren Co-promotores: dr. R. Janssen, RIVM Bilthoven February 1, 2018.

This is consistent with recent experimental work that attributes the immunosuppressive effects of measles to depletion of B and T lymphocytes.

A study has shown that the immunosuppressive effect of MSCs is mediated by the secretion of galectin - 3, a protein known to modulate T cell proliferation, gene expression, cell adhesion and migration 44.

The current immunotherapies are subject to the immunosuppressive effects of cancer, which likely contribute to their lack of success.

Many studies have demonstrated the immunosuppressive effects of the active derivative of vitamin D, 1,25 - dihydroxyvitamin D3 (1,25 -(OH) 2D3).

Their paper, published in Journal of Autoimmunity, reports that although the immunosuppressive effects of 1,25 -(OH) 2D3 on peripheral blood T cells of patients with RA is equal to that of controls, this is not reflected in T cells from the synovial fluid.

Aspirin directly inhibits the release of free fatty acids into the bloodstream (lipolysis) 795 - 797 and it also inhibits the enzyme responsible for the synthesis of cortisol.798 So while aspirin prevents the production of prostaglandins, it's also inhibiting cortisol production and lipolysis, which cuts off the direct estrogenic, anti-thyroid and immunosuppressive effects of unsaturated fatty acids.

Ashwagandha can significantly reduce cortisol concentrations and the immunosuppressive effect of stress.

Proliferative and degenerative diseases may occur in any of the tissues invaded by the virus, or the virus may be indirectly responsible for other illnesses because of its immunosuppressive effect.

Live worms seem to have an immunosuppressive effect; however the presence of dead worms leads to immune reactions and subsequent lung pathology in areas of the lung not directly associated with the dead HW.

While this can be life saving, the use of corticosteroids should be discontinued as quickly as possible so that their immunosuppressive effect does not interfere with successful treatment.

In cats, these tumors can occur under the immunosuppressive effect of the feline AIDS and Feline Leukemia virus.

Because of the immunosuppressive effects of influenza, bacterial infection may be of concern.

Corticosteroids (cortisone) should not be given even if the animal is experiencing itchiness, due to the immunosuppressive effects of these drugs.

Corticosteroids have immunosuppressive effects, which can compromise the functioning of the immune system.