Sentences with phrase «immunosuppressive tumor microenvironment»

«This immunosuppressive tumor microenvironment involves CD4 + and FoxP3 + cells that represent a regulatory T - cell population.

Genetically modified «hunter» T cells successfully migrated to and penetrated a deadly type of brain tumor known as glioblastoma (GBM) in a clinical trial of the new therapy, but the cells triggered an immunosuppressive tumor microenvironment and faced a complex mutational landscape that will need to be overcome to better treat this aggressive cancer, Penn Medicine researchers report in a new study this week in Science Translational Medicine.

Not exact matches

It's this «immunosuppressive» microenvironment that gives the remaining tumor cells license to metastasize and flourish in other parts of the body.

But T cells typically can not attack tumors because the immunosuppressive microenvironment of tumors keeps APCs from turning these signals on.

The paper identified two barriers: a wide variation in EGFRvIII expression in patients and a resistance in the tumor microenvironment, which researchers showed became even more immunosuppressive following CAR T cell infusion.

The ability of CD8 + T lymphocytes to eliminate tumors is limited by their ability to engender an immunosuppressive microenvironment.

Trp53 inactivation in the tumor microenvironment promotes tumor progression by expanding the immunosuppressive lymphoid - like stromal network.

One barrier to successful cancer immunotherapy is the tumor microenvironment, which recruits immunosuppressive cells that can inhibit endogenous anti-tumor responses.