Sentences with phrase «immunotherapeutic targets»
More importantly, this research highlights that HDAC11, which was the last of 11 HDAC to be discovered, should be treated as an immunotherapeutic target.
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«Targeting FAS - ligand could be a good adjunct therapy to boost the effects of immunotherapeutic drugs.»
One class of immunotherapeutic drugs is known as «checkpoint» inhibitors, as they target checkpoints in immune system regulation to allow the body's natural defenses, such as white blood cells, to more effectively target the cancer.
«Our findings are encouraging, as they suggest that entolimod can be safely combined with other chemotherapeutic, targeted or immunotherapeutic agents as treatment for advanced and very hard - to - treat cancers,» notes Dr. Adjei, who is Senior Vice President of Clinical Research and the Katherine Anne Gioia Chair in Cancer Medicine at Roswell Park.
One of the immunotherapeutic approaches that has been explored thus far relies on the use of monoclonal antibodies that specifically target a protein present on the surface of prostate cancer cells called prostate specific membrane antigen (PSMA) to elicit an anti-tumor immune response and control the cancer.
Our findings show how the tumor microenvironment drives the acquisition of CD39 as an immune regulatory molecule on CD8 + T cells, with implications for defining a biomarker of T cell dysfunction and a target for immunotherapeutic intervention.
4: Lobello K, Ryan JM, Liu E, Rippon G, Black R. Targeting Beta amyloid: a clinical review of immunotherapeutic approaches in Alzheimer's disease.
In addition to stem cell transplants, which have been used for decades, the immunotherapeutic antibody dinutuximab ⎯ which targets the glycolipid GD2 ⎯ is approved for childhood cancer patients with neuroblastoma.
Known as immunotherapeutic vaccines, they enlist a neutered version of viruses to infect healthy T cells and genetically modify them to target the disease.
Immunotherapeutic concepts to target acute myeloid leukemia: focusing on the role of monoclonal antibodies, hypomethylating agents and the leukemic microenvironment