Sentences with phrase «immunotherapies by»

Most recently, CRI has launched a new «venture philanthropy» program called the Cancer Vaccine Acceleration Fund (CVAF) as a means to catalyze development of next - generation therapeutic cancer vaccines and other immunotherapies by helping to address the critical shortage of capital available for early stage clinical trials.

Starting operations in 2012, iTeos Therapeutics is a clinical - stage biopharmaceutical company dedicated to extending and improving the lives of cancer patients by developing immunotherapies by design.

He adds: «This knowledge will enable us to significantly enhance cellular immunotherapies by guiding more T cells into a tumor.»

«If successful,» Zhou said, «all these efforts would remarkably improve the current cancer immunotherapies by personalizing the treatment to exactly where and when it is needed, while reducing side effects.»

«Cancers evade immunotherapy by «discarding the evidence» of tumor - specific mutations: Discovery could explain widespread acquired resistance among patients treated with immune checkpoint blockade drugs.»

«This is an important demonstration of the possibilities opened up for immunotherapy by DMAb technology to direct in vivo production of antibodies of major relevance to human cancer,» said David B. Weiner, Ph.D., executive vice president of The Wistar Institute, director of The Wistar Institute Vaccine & Immunotherapy Center, W.W. Smith Charitable Trust Professor in Cancer Research, and senior author of the study.

The paper, «Enhanced Cancer Immunotherapy by Microneedle Patch - Assisted Delivery of Anti-PD-1 Antibody,» is published in the journal Nano Letters.

That's likely to change rapidly with the creation of the Parker Institute for Cancer Immunotherapy, a $ 125 million contribution to Johns Hopkins for immunotherapy by former New York mayor Michael Bloomberg and other philanthropists, and President Obama's «moonshots» effort to accelerate research.

June 13, 2016 Radiation and vaccination can magnify effects of immunotherapy By combining local radiation therapy and anti-cancer vaccines with checkpoint inhibitors, researchers from the University of Chicago, working with mice, were able to increase the response rate for these new immunotherapy agents.

Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, Minato N. Involvement of PD - L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD - L1 blockade.

Building on the pioneering work of the Ludwig Cancer Research (LICR), iTeos is aiming to unlock the full potential of immunotherapy by improving the frequency, depth and duration of response, and by extending therapeutic benefit to more patients.

November 5, 2015 Gut bacteria can dramatically amplify cancer immunotherapy By introducing a particular strain of bacteria into the digestive tracts of mice with melanoma, researchers at the University of Chicago were able to boost the ability of the animal's immune systems to attack tumor cells.

Not exact matches

That said, there is a growing sense among many cancer experts that immunotherapy could improve by leaps and bounds if the right mysteries are unlocked.

Dr. Peter Kiener has substantial experience in both biologics and immunotherapy, and was most recently the Chief Scientific Officer at Sucampo, which was acquired by Mallinckrodt in February 2018 for approximately $ 1.2 billion.

Immunotherapy is praised by researchers because it is targeted, focusing on cancerous cells rather than healthy tissue, as well as potentially durable.

Led by Nina Bhardwaj, M.D., director of immunotherapy, the Personalized Genomic Vaccine trial uses the genetic sequence of a patient's tumor to create a customized vaccine.

Merck (mrk) beat competitor Bristol - Myers Squibb (bmy) to a pioneering 2014 approval for its immunotherapy Keytruda by about three months.

The cancer immunotherapy market is projected to reach $ 111.23 billion by 2021 and there's been plenty of VC activity there lately.

Some of the smaller companies developing immunotherapy drugs could be acquired by the pharmaceutical giants, analysts said.

JCAR015 is among CAR T - cell candidates covered by Juno's 10 - year, approximately $ 1 billion global collaboration launched in 2015 to develop and commercialize cancer and autoimmune diseases immunotherapies.

The primary reason for this reduction was a slowdown in sales for cancer drug Abraxane, which has been hit by the expansion of cancer immunotherapies into new indications.

Turnstone Biologics, a startup co-founded by FACIT, announced a research, option and license agreement with AbbVie Inc. for up to three of Turnstone's next - gen oncolytic viral immunotherapies.

«The event, the fourth of its kind, seeks to raise global awareness and create a forum for collaboration around the wide array of powerful and promising cell therapies, gene therapies, and immunotherapies emerging from medical institutions around the world, as well as the impact new technology will have on humanity and society,» a press release by the Cure Foundation explains (h / t Christian Post).

By comparing the results to cells from paired normal tissue, researchers get a detailed molecular picture of the tumor environment, including the types and activity levels of T cells that are critical to the immunotherapy response.

Much current research in immuno - oncology focuses on improving these treatments, for example, by finding new immunotherapy targets and identifying biomarkers that predict a patient's response.

A new study by Dana - Farber Cancer Institute scientists suggests it may be possible to prevent tumors from recurring and to eradicate metastatic growths by implanting a gel containing immunotherapy during surgical removal of a tumor.

«Novel mechanism by which tumors evade cancer immunotherapies.»

A Ludwig Cancer Research study led by Benoit Van den Eynde, Director of Ludwig Brussels, has identified a novel mechanism by which tumors of the aggressive skin cancer melanoma can resist cancer immunotherapy.

Their paper, which appears in Nature Communications, describes how an immune cell recruited to the tumor induces the programmed suicide, or apoptosis, of the killer T cells harnessed by many immunotherapies.

Pembrolizumab, or pembro, an immunotherapy drug that unmasks cancer cells and allows the body's own immune system to help destroy tumors, appears to be safe in treating lung cancers, according to a study by Cancer Treatment Centers of America ® (CTCA) at Western Regional Medical Center (Western) in Goodyear, Arizona.

The discovery has powerful implications for cancer immunotherapy researchers say: by blocking the mechanism with a drug, it may be possible to turn the attack - suppressing cells into tumor - attacking cells.

Immunotherapy doubles overall survival and improves quality of life, with fewer side effects, in a treatment - resistant and rapidly progressing form of head and neck carcinoma, reports a large, randomized international trial co-led by investigators at the University of Pittsburgh Cancer Institute (UPCI).

Now, by harnessing advances in genome editing to slice and dice genes in donor T cells, researchers have created a new type of cancer immunotherapy.

My next career step was to accept a 6 - month position, which was then extended by an additional year, to establish a translational research laboratory for cancer immunotherapy at the Gustave Roussy Cancer Campus, a major nonprofit health care, research, and teaching institution in Paris.

Immunotherapy caused an increase in peanut - specific T cells, accompanied by a change in the distribution of T - cell subtypes over time.

Today's immunotherapy researchers not only will need to borrow the methods once popularized by Coley, but also his implacable personality.

«A personalised immunotherapy was prepared for each patient by taking a sample of their blood and extracting a particular type of immune cell called dendritic cells.

In 2009, BMS took a big risk jumping into the immunotherapy field by acquiring the company Medarex, which brought with it Yervoy, a member of a new class of cancer drugs.

Funding for the study was provided by the National Institutes of Health (P50 CA083638, R21 CA156224, 5P30 CA016520 - 36), the Marcus Foundation, the Ovarian Cancer Immunotherapy Initiative, the Ludwig Institute for Cancer Research at the University of Lausanne, and the Ovacure Foundation.

Soon afterward, Allison returned to MD Anderson, lured by the opportunity to launch the center's $ 30 million Moon Shots immunotherapy research program.

«The hope is to enhance certain immunotherapy drugs by adding such glutamine antagonists,» says Powell.

Using an approach developed at Maisonneuve - Rosemont, consisting of an autograft to reduce tumour mass followed by a family allograft three to four months later to clean the bone marrow of myeloma cells with immune cells from a family donor (immunotherapy), the study resulted in a total cure rate of 41 %, a record level using this strategy.

The immunotherapy drug pembrolizumab — already FDA - approved for other forms of cancer - has been found to be effective in patients with metastatic triple negative breast cancer, according to an international clinical trial led by NYU Langone's Perlmutter Cancer Center.

They elaborate on several focus areas described by the White House earlier: preventive vaccines, early detection, single cancer cell genomics, immunotherapy, pediatric cancer, and data sharing.

The study has also grabbed attention because — as first reported by the MIT Technology Review — tech entrepreneur Sean Parker's new $ 250 million Parker Institute for Cancer Immunotherapy will fund the trial.

Combining their strategy with an existing immunotherapy treatment that works by releasing the «brakes» on immune cells, they found they could shrink melanoma tumors, and prolong survival in preclinical models for melanoma.

These drugs work by targeting the PDL - 1 receptor — a known immunotherapy biomarker for lung and other cancers — to boost immune responses to the cancer.

The trial, sponsored by the Parker Institute for Cancer Immunotherapy in San Francisco, California, could begin in 6 to 8 months.

In light of recent findings and future promises, cancer immunotherapy has even been chosen as scientific breakthrough of the year 2013 by the journal Science.

Cancer immunotherapies work by activating T cells to kill tumors.