Sentences with phrase «immunotherapy agents»
To combat the nation's third deadliest cancer, the phase 1b / 2 open - label study will explore the combination of standard chemotherapy and two immunotherapy agents: an anti-PD-1 checkpoint inhibitor and a novel antibody targeting CD40, a protein that when activated can drive the immune system to attack tumors.
http://cancerresearch.org/
Given the substantial increase in development activity and clinical success of other immunotherapy agents that followed, and in an effort to continue to provide maximum value to the rapidly evolving field, the direction of the CIC was re-set to become a «think tank» that would convene and tackle topics of importance to the continued development of cancer immunotherapies.
June 13, 2016 Radiation and vaccination can magnify effects of immunotherapy By combining local radiation therapy and anti-cancer vaccines with checkpoint inhibitors, researchers from the University of Chicago, working with mice, were able to increase the response rate for these new immunotherapy agents.
Immunotherapy agents on their own have limitations, and it will take multi-modality approaches to cure most cancers.
NEW YORK AND SAN DIEGO (Sept. 3, 2014)-- The nonprofits Ludwig Cancer Research (Ludwig) and the Cancer Research Institute (CRI) announced today an agreement with VentiRx Pharmaceuticals Inc., a clinical stage biopharmaceutical company, to conduct a clinical trial with motolimod (VTX - 2337) combined with other immunotherapy agents available to Ludwig and CRI through other industry partnerships.
During those studies, he found the synergy between these two immunotherapy agents as well.
In addition to formulating diagnostic strategies for cancer immunotherapy agents, her team is focused on developing a deep understanding of tumor immune biology as well as mechanisms associated with immune response and immune escape in cancer patients, with the intent of generating rational strategies for the creation of combination therapies.
The next year, the FDA approved another immunotherapy agent, ipilimumab, to treat melanoma.
«Immunotherapy agent benefits patients with drug - resistant multiple myeloma.»
Not exact matches
Of the 21 patients treated, nine previously either had stable disease or responded to single - agent immunotherapy before becoming resistant to this treatment.
But rather than writing off cancer immunotherapy, some researchers argue that the agents have been examined in the wrong way, resulting in erroneous conclusions.
«We also have data suggesting that this immunotherapy works synergistically with chemotherapy, so testing the effect of this immune targeting agent with chemotherapy was a natural step.»
UC San Diego School of Medicine is among 27 research institutions selected to be part of the National Cancer Institute - funded Cancer Immunotherapy Trials Network — to find agents that harness patients» immune systems to fight their cancer.
In my professional career, I have focused both on developing precision medicine agents as well as immunotherapies.
Systemic immunotherapy treats the whole body by administering an agent such as the protein interferon alpha that can shrink tumors.
Upcoming interventional trials will examine immunotherapy in combination with other novel agents in an effort to improve both short - and long - term outcomes for patients.
Lentiviral vectors are promising agents for cancer immunotherapy, but this research is still in the pre - clinical / early clinical stages.
Both recent experience with immunotherapy for clearance of Aβ in AD, and their own (and Prothena's) experience with AS - clearing immunotherapies in animal models, indicate that in order to be effective as disease - modifying agents when administered alone, therapies that remove proteinaceous aggregates from the brain must be initiated in the early clinical or even preclinical stages of the disease, before the burden of other forms of aging damage becomes entrenched.
Building on clinical data from several single - agent immunotherapy clinical trials, and by engaging scientists with unique and complementary expertise from eight institutions and three industry partners, the BEAT - HIV Collaboratory's central mission will be to develop and test innovative combined immunotherapy strategies to eradicate and / or permanently suppress HIV replication in the absence of ART.
Research in the Leukemia Program spans from direction of clinical trials to basic molecular studies of leukemia biology, immunotherapy and development of novel agents, and to mitigating the late effects of treatment in long - term survivors.
In addition to conserved antigens, these next - gen ZVex agents will be designed to produce personalized neoantigen - based immunotherapies, as well.
Over the past 5 years, a number of new pharmacologic treatments for advanced melanoma have been introduced, including immunotherapy, targeted agents (BRAF and MEK inhibitors), and oncolytic viral therapy.
Preliminary analyses of the results of the first combination trials, which show higher response rates than with either agent alone, offer some optimism that these locoregional therapies will find application — as treatment for patients who can not tolerate systemic immunotherapies, to alleviate locoregional morbidity, and perhaps even to «prime» the immune system.
On the other hand, allergies to environmental agents like pollen or mold can be difficult to avoid, in which case your vet may recommend immunotherapy or treatment with antihistamines.