Sentences with phrase «immunotherapy combination for»
Not exact matches
«While we are disappointed CheckMate - 026 did not meet its primary endpoint in this broad patient population, we remain committed to improving patient outcomes through our comprehensive development program, including the ongoing Phase III CheckMate - 227 study exploring the potential of the combination of Opdivo plus [our other cancer immunotherapy] Yervoy for PD - L1 positive patients, and Opdivo plus Yervoy, or Opdivo plus chemotherapy in PD - L1 negative patients,» he added.
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And using lower levels of Yervoy in combination with Opdivo actually prompted more tumor shrinkage, underscoring the fact that dosing is a critical and unpredictable factor for immunotherapies.
In addition to formulating diagnostic strategies for cancer immunotherapy agents, her team is focused on developing a deep understanding of tumor immune biology as well as mechanisms associated with immune response and immune escape in cancer patients, with the intent of generating rational strategies for the creation of combination therapies.
«Combination immunotherapy effective for advanced prostate cancer.»
«Immunotherapy combination promising for untreated patients with advanced melanoma.»
These therapies could enhance the effects of novel cancer immunotherapies when used in combination, resulting in better health outcomes for cancer patients.
To investigate why checkpoint inhibitors so often stop working, Velculescu; Valsamo Anagnostou, M.D., Ph.D., instructor of oncology at the Johns Hopkins University School of Medicine; Kellie N. Smith, Ph.D., a cancer immunology research associate at the Johns Hopkins University School of Medicine; and their colleagues at the Bloomberg ~ Kimmel Institute for Cancer Immunotherapy studied tumors of four patients with non-small cell lung cancer and one patient with head and neck cancer who developed resistance to two different checkpoint inhibitors: a drug called nivolumab that uses an antibody called anti-PD-1, or nivolumab used alone or in combination with a second drug called ipilimumab, which uses an antibody called anti-CTLA4.
Combination immunotherapy with nivolumab and ipilimumab as tested in the kidney cancer study described here is already FDA - approved for treatment of melanoma, and is being tested for other cancers.
The U.S. Food and Drug Administration granted approval to the combination of two immunotherapy drugs, ipilimumab and nivolumab, for the treatment of metastatic kidney cancer.
Early this week, the U.S. Food and Drug Administration (FDA) approved a combination immunotherapy regimen for treating certain patients newly diagnosed with advanced renal cell carcinoma, the most common form...
Visit our website to find out more about the Clinical Accelerator and for information about combination therapies that came out of our 2013 Cancer Immunotherapy Consortium meeting.
Society for Immunotherapy of Cancer (SITC) Symposium Combination Cancer Immunotherapy: Expanding Clinical Success Saturday, May 5, 8:00 AM — 10:00 AM, Room 12AB Chairs: Bernard A. Fox, Earle A. Chiles Res.
Upcoming interventional trials will examine immunotherapy in combination with other novel agents in an effort to improve both short - and long - term outcomes for patients.
Sharma spoke about one example of this approach: a recently launched CRI Clinical Accelerator trial testing a CD40 - based immunotherapy in combination with checkpoint immunotherapy and chemotherapy for patients with pancreatic cancer.
Additional trials utilizing this vaccine are ongoing in glioblastoma, while a vaccine and checkpoint immunotherapy combination trial is being planned for patients with bladder cancer.
In addition to bevacizumab (Avastin ®) a targeted antibody that is already approved for cervical cancer patients, there are several other types of immunotherapies that are being evaluated for cervical cancer, including some in combination.
The goal is to test if targeting the vitamin D receptor will unlock the potential of immunotherapies to kill pancreatic cancer tumor cells and potentially establish a therapeutic combination for controlling advanced pancreatic cancer, extending patient survival, and reducing patient side effects.
Immunotherapy can be used for many types of cancer, either alone or in combination with other treatments.
In particular, Dr. Azad's laboratory and clinical trials explore epigenetic therapy in combination with chemotherapy and immunotherapy to improve survival for patients, as well as molecularly targeted drugs.
Researchers are investigating nanoparticles for delivery of immunostimulatory or immunomodulatory molecules in combination with chemo - or radiotherapy or as adjuvants to other immunotherapies.
Preliminary analyses of the results of the first combination trials, which show higher response rates than with either agent alone, offer some optimism that these locoregional therapies will find application — as treatment for patients who can not tolerate systemic immunotherapies, to alleviate locoregional morbidity, and perhaps even to «prime» the immune system.
«Immune checkpoint inhibitors, including PD - 1 and PD - L1 inhibitors, have provided meaningful clinical benefits for patients with cancer; however, novel immunotherapy combination treatments are needed to improve efficacy with limited additive toxicity,» said Aung Naing, MD, FACP, associate professor, Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston.
The children received omalizumab or a placebo for eight weeks before starting immunotherapy and for eight weeks during combination treatment with immunotherapy for two to five trigger foods.
However, we have found that dogs with low - grade glioma respond well to the combination of surgery and immunotherapy, and we are prolonging the disease free interval for dogs with high - grade glioma while providing an excellent quality of life.