Phase 1b study of a novel
immunotherapy combination therapy of intralesional Coxsackievirus A21 and systemic ipilimumab in patients with advanced melanoma.
They suggest allocating greater resources to research focused on immune checkpoint therapies and targeted /
immunotherapy combination therapies with «curative potential.»
Not exact matches
To achieve this goal, the cancer field is moving away from chemotherapy and towards a
combination of
immunotherapy and targeted
therapy, an approach that is more potent and less toxic.
In addition to formulating diagnostic strategies for cancer
immunotherapy agents, her team is focused on developing a deep understanding of tumor immune biology as well as mechanisms associated with immune response and immune escape in cancer patients, with the intent of generating rational strategies for the creation of
combination therapies.
«
Immunotherapy, gene
therapy combination shows promise against glioblastoma.»
These
therapies could enhance the effects of novel cancer
immunotherapies when used in
combination, resulting in better health outcomes for cancer patients.
Combination therapy with two
immunotherapy drugs produces an unprecedented doubling of response rates from 20 percent to 40 percent, a new study shows.
«The hope is that the
combination of the most potent chemotherapy, radiation
therapy, and
immunotherapy will help make patients who were previously considered non-surgical able to undergo curative surgery,» says Gan.
To meet this end, CCIR members take advantage of resources offered by MD Anderson, including the CCSG Shared Resources, Immune Monitoring Core Laboratory and GMP Cell Facility, allowing them to follow the «bench - to - beside» approach to develop and improve cancer
immunotherapy in the form of cellular
therapy, a vaccine or targeting antibody, either alone or in
combination with conventional
therapies or newly developed
therapies.
If you've seen cancer
immunotherapy in the news recently, you probably have heard about
combination therapies.
The CRI Cancer
Immunotherapy Consortium hosts its 2011 Colloquium, the first meeting of its kind to focus on Schedule and Dose in
Combination Therapy.
Visit our website to find out more about the Clinical Accelerator and for information about
combination therapies that came out of our 2013 Cancer
Immunotherapy Consortium meeting.
Current clinical trials include
combination of intrahepatic embolization and a radiosensitizer in patients with uveal melanoma and liver - only metastases, a phase I trial that evaluates a
combination therapy of BCG with ipilimumab in Stage III / IV melanoma, and several landmark international trials including a phase II trial that evaluates
combination immunotherapy with nivolumab & ipilimumab.
The team will identify genetic and epigenetic features in CAR T cells and / or cancer cells that will help predict which patients will respond to the
immunotherapy, with an eventual goal of initiating clinical trials that employ a
combination of approaches to
therapy.
In particular, Dr. Azad's laboratory and clinical trials explore epigenetic
therapy in
combination with chemotherapy and
immunotherapy to improve survival for patients, as well as molecularly targeted drugs.
Now, we're conducting clinical trials to test these targeted
therapies in
combination with
immunotherapy to treat KRAS - driven NSCLC.
Preliminary analyses of the results of the first
combination trials, which show higher response rates than with either agent alone, offer some optimism that these locoregional
therapies will find application — as treatment for patients who can not tolerate systemic
immunotherapies, to alleviate locoregional morbidity, and perhaps even to «prime» the immune system.
Each type of cancer requires individual care and may include a
combination of treatment
therapies such as surgery, chemotherapy, radiation, cryosurgery (freezing), hyperthermia (heating) or
immunotherapy.
Sometimes cancer is curable - especially if caught early, but often it is a chronic disease that is managed by a
combination of surgery, chemotherapy, radiation and some new innovative treatments like antibody
therapy,
immunotherapy, vaccines, cyberknife
therapy, etc..
Chances of your pet's survival increase if the surgery is followed by
combinations of radiation
therapy and
immunotherapy.
Typically, cancers may be treated with
combinations of surgery, chemotherapy, radiation
therapy, and sometimes
immunotherapy.