Sentences with phrase «impact of changes over»

Most studies looked at the quality of a marriage and the risk of cardiovascular disease (CVD) at a single point in time, rather than the potential impact of changes over time.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

Russ Corsi, who worked nearly 32 years for Pittsburgh - based PPG, a global supplier of auto glass, says larger sunroofs are also more prone to weakening over time as the pane absorbs impacts from bumps in the road, twists and turns of the car's frame, and «thermal shock» — the expanding and contracting from sudden temperature changes.

«Even though the pace of advances in robotics and artificial intelligence may accelerate over the next two decades, the impact of that change — whether it tends to increase or decrease employment — depends not on the technology, but on demand.

«When you have thousands of people coming to your site every day, if making one little change like putting a security logo on your checkout page makes a 1 percent difference in conversion rate a day that can make a huge impact on your bottom line over time.»

Ultimately, McCoy was trying to fix an unimaginable mess at a company with operations all over the world, and proved slow to react to market changes such as the impact of e-commerce and changing demographics.

Given all the changes over the past three decades, Davidoff citing a study of the impact of New York financial transaction taxes from 1932 to 1981 is interesting from a historical perspective but not much more.

Over the course of 18 months, Toyota's team made simple changes that had deep and lasting impact throughout the organization.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

But according to Pandora's new CEO — who quickly began implementing a number of changes to reinvigorate growth ranging from investments in Pandora's ad tech, marketing, distribution partnerships, and new content launches — most of their new growth initiatives are «still in early stages, and their impact will build over the course of 2018.»

And it crosses over all these lines: local environmental impact, there's the climate argument, there's the First Nations rights argument, there's the stewardship argument, so it can really draw from a whole wide sector of civil society in the way that the faceless catastrophe of climate change can't.

This may be one of the reasons why this equation shows a relatively small impact over the first year or so following an interest rate change.

Such risks and uncertainties include, but are not limited to: our ability to achieve our financial, strategic and operational plans or initiatives; our ability to predict and manage medical costs and price effectively and develop and maintain good relationships with physicians, hospitals and other health care providers; the impact of modifications to our operations and processes; our ability to identify potential strategic acquisitions or transactions and realize the expected benefits of such transactions, including with respect to the Merger; the substantial level of government regulation over our business and the potential effects of new laws or regulations or changes in existing laws or regulations; the outcome of litigation, regulatory audits, investigations, actions and / or guaranty fund assessments; uncertainties surrounding participation in government - sponsored programs such as Medicare; the effectiveness and security of our information technology and other business systems; unfavorable industry, economic or political conditions, including foreign currency movements; acts of war, terrorism, natural disasters or pandemics; our ability to obtain shareholder or regulatory approvals required for the Merger or the requirement to accept conditions that could reduce the anticipated benefits of the Merger as a condition to obtaining regulatory approvals; a longer time than anticipated to consummate the proposed Merger; problems regarding the successful integration of the businesses of Express Scripts and Cigna; unexpected costs regarding the proposed Merger; diversion of management's attention from ongoing business operations and opportunities during the pendency of the Merger; potential litigation associated with the proposed Merger; the ability to retain key personnel; the availability of financing, including relating to the proposed Merger; effects on the businesses as a result of uncertainty surrounding the proposed Merger; as well as more specific risks and uncertainties discussed in our most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.cigna.com as well as on Express Scripts» most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.express-scripts.com.

These risks and uncertainties include food safety and food - borne illness concerns; litigation; unfavorable publicity; federal, state and local regulation of our business including health care reform, labor and insurance costs; technology failures; failure to execute a business continuity plan following a disaster; health concerns including virus outbreaks; the intensely competitive nature of the restaurant industry; factors impacting our ability to drive sales growth; the impact of indebtedness we incurred in the RARE acquisition; our plans to expand our newer brands like Bahama Breeze and Seasons 52; our ability to successfully integrate Eddie V's restaurant operations; a lack of suitable new restaurant locations; higher - than - anticipated costs to open, close or remodel restaurants; increased advertising and marketing costs; a failure to develop and recruit effective leaders; the price and availability of key food products and utilities; shortages or interruptions in the delivery of food and other products; volatility in the market value of derivatives; general macroeconomic factors, including unemployment and interest rates; disruptions in the financial markets; risk of doing business with franchisees and vendors in foreign markets; failure to protect our service marks or other intellectual property; a possible impairment in the carrying value of our goodwill or other intangible assets; a failure of our internal controls over financial reporting or changes in accounting standards; and other factors and uncertainties discussed from time to time in reports filed by Darden with the Securities and Exchange Commission.

It is hard to judge right now what the economic impact will be of this changing culture over time.

Due to potentially - large oscillations in the desire to hold cash and to the fact that changes in the money supply can take years to impact the cost of living, this theoretical rate of purchasing - power change will tend to be inaccurate over periods of two years or less but should approximate the actual rate of purchasing - power change over periods of five years or more.

This is expected to change over time as more bitcoin exchanges gain trading volume in different countries thereby weakening the impact of regional variances.

However, much of this drop was due to demographic change, and a slight reduction in the unemployment rate over that period helped to mitigate the impact on employment.

Personally i think those specific prayers are a distraction most of the times we pray these prayers because its what we think we need and often thats not the case.The better way is to just trust the holy spirit let him lead i think we miss the awesomeness of doing it Gods way its easy not difficult.The struggle is difficult when we are walking by the flesh and trying to do it our way.When i got to the point where i said to the God i am not going to do it my way anymore and i submit to you because know whats best for me.Change me and when i feel the wrong desires or temptation to walk by the flesh i just say Lord you know i am weak and i can not live a christian life without you help me.As soon as i do that it is effortless theres no struggle thats how we should grow.I am excited with what God is doing in my life he has opened his word i am seeing the fruit of his life impacting mine and i am changing day by day.I am walking by faith and not slipping back into my old desires i know what it means to be an overcomer sin does not have dominion over me anymore.In myself i can not boast because it is the power of God at work in my life and i give all the praise back to God.brentnz

Such intra group communication changes are of great significance to faith communities; however, this often is neglected in our concern over the impact of mass media.

And even if, moment - by - moment, the novelty and spontaneity is quite small, over time it can change the impact of the past on the present quite dramatically.

(Indeed, fascinating histories might be written of major changes in the identities of both denominational and university - related theological schools that came about over the past thirty years not by grand vision and masterful decision but through the accumulated impact of individual decisions about particular proposed courses, programs for this and centers for that.)

It is one, though, that is having a much more significant impact on the understanding and practise of religious faith because it is laying the foundations for a change that will be durable over a much longer period of time.

The site makes it possible for CSIRO to conduct long - term farming systems experiments that investigate changes to the soil over time and provide a better understanding of the impact of factors such as soil organic matter and soil acidity on farm profitability.

«What has changed over the years is that the impact of the finances in the CL is not as big any more.

With Barca set to make changes to their starting line - up, he'll be hopeful of getting some playing time and having an impact before the season is over.

Chelsea made plenty of changes over the summer and in January, with the likes of Nemanja Matic, Diego Costa and Michy Batshuayi among those to recently leave, while unconvincing additions such as Alvaro Morata, Tiemoue Bakayoko, Danny Drinkwater and Olivier Giroud have come in and made minimal impact.

«What has changed over the years is that the impact of the finances in the Champions League is not as big anymore.

The impacts of motherhood will result in fundamental changes in your wife over a short time period.

«We hope these findings will help foster discussion both about how changes in pediatric athletic participation over the past 20 years may be impacting injury rates and how we can best develop youth injury prevention programs and athletic participation guidelines,» said Marc A. Tompkins, MD, an assistant professor of orthopaedic surgery at the University of Minnesota.

The resulting data is used to compare relative abundance of seabirds over time — to help us understand populations within the sanctuary and their possible impacts on local ecosystems and as a barometer for other changes in the environment.

With data collected over time, the study will increase our understanding of the local impacts of climate change and contribute to the natural history of Great Lakes fish.

-- Climate change could impact many Bay State birds — including familiar species such as the Black - capped Chickadee — over the next 30 - 50 years, according to Mass Audubon's State of the Birds: Massachusetts Birds and Our Changing Climate.

Climate change could impact many Bay State birds — including familiar species such as the Black - capped Chickadee — over the next 30 - 50 years, according to Mass Audubon's State of the Birds: Massachusetts Birds and Our Changing Climate.

Because of changes in adoption over the last few decades — changes that include open adoption, gay adoption, international adoptions and trans - racial (racial transformation) adoptions, and a focus on moving children out of the foster care system into adoptive families — the impact of adoption on the basic unit of society and the family, has been enormous.

Disability Alliance (now Disability Rights UK) stated that it was «very concerned» the timetable allowed for the passage of the Bill could «prevent adequate analysis of the potential impact of plans to be undertaken» and warned that it may take legal action against the DWP over some of the proposed changes.

Despite the pause button having been pressed over the Hinkley Point project by the new May administration in July, the resulting «new» safeguards put in place to cover Chinese involvement do not appear that different from the old arrangements, implying that the Brexit - led change of leadership in Westminster may have little impact on Chinese access to such projects in future.

Indeed there is no doubt that the future direction of the European Union will have a major impact on the political landscape of the UK: Completion of the single market, enlargement, climate change and security are some of the salient challenges which Member States will confront over the coming years and we as British Conservatives should be at the forefront of those advocating sensible and workable solutions.

Meanwhile, the piece of legislation that could have the greatest impact on rent that is being backed by advocates would change the requirements for serving on the Rent Guidelines Board — the group that sets the rates for rent - controlled apartments and give the City Council approval over the Mayor's appointments to the body.

Attorney General Eric Schneiderman's office on Thursday continued to question the legitimacy of a review by House Republicans into an investigation over whether ExxonMobile understated the impact of climate change.

But Republican challenger Seth Allen, a 27 - year - old newcomer, hopes to turn some of those accomplishments into vulnerabilities by capitalizing on voter discontent over some of the changes impacting Uptown Kingston.

The government is also under pressure over the possible impact on family budgets of changes to welfare, following reports that Iain Duncan Smith, the work and pensions secretary, is looking at plans to cut child benefit.

We don't yet know for sure the impact of the reduction in the number of constituencies — the Conservatives should be the net beneficiaries, but the parties will fight over every boundary line; until the new map is drawn we won't know how many seats will change hands for a given swing.

There is now a «clear and overwhelming consensus» among scientists over the reality and risks of climate change, Mr Noon told delegates, calling on the TUC and UK to show leadership and commitment towards averting its environmental impact.

Earlier on Monday, a report by Policy in Practice — a group that works with local authorities on welfare changes — revealed the impact on two - thirds of working tax credit recipients over the next five years, and suggested that the # 4.4 bn savings from the tax credits package would be partly offset by higher housing benefit and council tax support payments.

That's why we have to look at the balance in terms of what is cheaper: Can we reduce emissions of greenhouse gases today so that we can stabilize the earth's climate, rather than adapt to the impacts of climate change and incur much higher costs over a period of time?

... We have established an Indian Network for Comprehensive Climate Change Assessment, a network of over 120 research institutes, which will bring out regular reports on the impacts of climate change on different sectors and different regions of the coChange Assessment, a network of over 120 research institutes, which will bring out regular reports on the impacts of climate change on different sectors and different regions of the cochange on different sectors and different regions of the country.

Back in the lab, they will analyze the mosaics to see how the reefs are changing over time, and how the variation of ocean conditions and human activities impact each reef.

We should get the best science and stay abreast of any threat from human impacts, but I am disturbed that we have spent over thirty billion dollars studying climate change and have little to show for it.

Short - and long - term impacts The American economy is already beginning to feel the effects of climate change, the report says, and «these impacts will likely grow materially over the next 5 to 25 years and affect the future performance of today's business and investment decisions.»