Not exact matches
DBL Investors A spinoff
of J.P. Morgan, DBL has become one
of the nation's top
impact investors, thanks to its $ 75 million Bay Area Equity
Fund I. (Among DBL's portfolio firms is Tesla, the electric - car company that went
public last June.)
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and
public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount
of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability
of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction
of generic versions
of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect
of lowering prices or reducing the number
of insured patients; the possibility
of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels
of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits
of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages
of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development
of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate
of the U.S. dollar that may cause an unfavorable foreign currency exchange
impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
Question: How do you think recent poor performance
of the
public market will
impact early stage companies, such as those seeking seed or Series A
funding?
This area covers the
impact of policies affecting Canadians» health and long - term care choices and outcomes, for example regarding access to and quality
of care,
funding arrangements and incentives, pharmaceuticals policies, intergenerational equity considerations, and the
impact of these choices on the
public purse.
Infrastructure Minister Amarjeet Sohi, a low - profile minister with a high -
impact portfolio, must hammer out huge bilateral deals with all the provinces for their slices
of $ 33 billion in federal
funds for ribbon - cutting - worthy projects like big
public transit expansions.
In the July 2010 version
of their paper entitled «The
Impact of Investor Sentiment on the German Stock Market», Philipp Finter, Alexandra Niessen - Ruenzi and Stefan Ruenzi test the predictive power
of a composite sentiment measure combining consumer confidence, net equity mutual
funds flow, put - call ratio, aggregate trading volume, initial
public offering (IPO) returns, number
of IPOs and aggregate equity - to - debt ratio
of new issues.
«The lack
of transparency in assigning
public funds and the discriminatory
impact on how vulnerable communities in particular are devastated by austerity may become evident again as Puerto Rico awaits disaster relief
funds, and communities await to see how those
funds will be distributed,» she wrote.
From a financial standpoint, the
impact is also very limited because most, if not all,
of the debt Greece owes is held by
public and governmental entities: the International Monetary
Fund, the European Union and the European Central Bank (ECB).
Recent estimates by the International Monetary
Fund (IMF) indicate sizeable and long - lasting
impacts of public infrastructure spending on private investment and output.
«Noting the fact that the Sexual Orientation Regulations are being voted on in the House
of Commons today,» said the Cardinal, «I again express our concern at their
impact, not only on adoption services, but on cooperation between faith - based voluntary agencies and
public authorities in
public funded services....
And Betti Wiggins, executive director
of the Office
of School Nutrition for Detroit
Public Schools, says moving to the new program had zero
impact on the city's Title I
funding.
An article on the environmental
impact of the production and disposal
of millions
of plastic and cloth diapers reveals the length to which corporations will go to ensure profit margins: couching advertisements in «scientific studies»;
funding studies based on controversial methodologies; using unscientific statistical studies to cook the books on cost - benefit analyses
of environmental damage; and employing shrewd, manipulative and effective
public - relations strategies.
Tentative deals have been reached on parts
of a new state budget, including about $ 1 billion in additional
funding for
public schools, a work - around for some higher - income New Yorkers to reduce the
impact of new federal tax deduction limits, and a freeze on what Albany sends to local governments around the state.
Funding for the programs can be federal, state, private, from public - private partnerships, income share agreements, social impact bonds or any combination of the funding streams, sh
Funding for the programs can be federal, state, private, from
public - private partnerships, income share agreements, social
impact bonds or any combination
of the
funding streams, sh
funding streams, she said.
He charged that restoration
of funding for specific departmental legislative branch personnel «without considering the respective value
of the positions» functions, in the context
of the overall city budget and
impact on our city's tax base, is not only unjustifiable but wreaks
of putting politics between the
public interest.»
Mayor Bill de Blasio has a simple message about the local
impact of the $ 168.3 billion state budget: Now that the governor has secured
funding he was seeking for subways and
public housing, he is responsible for some
of New York City's most intractable problems.
As
public sector prisons move towards the thin staffing level model
of profit - making institutions, with their high turnover
of personnel who are less connected to their occupation, a study
funded by the Economic and Social Research Council (ESRC) warns
of a potentially detrimental
impact on prison quality.
Also at 10:30 a.m., the Assembly will hold a
public hearing to examine the
impact of the Renewable Portfolio Standard program and the proposed creation
of the Clean Energy
Fund for the advancement
of large scale renewable energy production, Assembly Hearing Room, 250 Broadway, Room 1923, 19th Floor, Manhattan.
State Comptroller Tom DiNapoli, sole trustee
of the state
public employee pension
fund, is again pushing for energy giant ExxonMobil to disclose how efforts to mitigate global warming will
impact its corporate bottom line.
In an effort to jumpstart all - but - stalled negotiations on a new evaluation system for New York City
public school teachers, StudentsFirstNY today launched a «10 Days
of $ 300 Million» campaign to highlight the negative
impact of losing these
funds.
Dozens
of workshops covered a range
of issues, including the
impact of the State budget on counties, pension
funding, renewable energy, local Medicaid costs,
public safety, budgeting, pre-school special education reforms, shared services, and local leadership.
City Council Finance Chair Carolee Conklin spoke with WXXI's Bob Smith about the city budget in including the
impact of Albany's budgeting and policies, and the obligations the city has to help
funding public education.
«U.S.
funding is insufficient to address the human health
impact of and
public - health responses to climate change,» the report's authors caution.
«We in the science community should do more to satisfy the
public interest in quantifying the
impact of federally -
funded medical research,» said Cruea.
And stimulus money not aimed specifically at the sciences has nonetheless softened the
impact of reduced state
funding at many
public universities, allowing some to borrow against future retirements to hire new faculty members now.
Such steps are likely to include better documentation
of how each award satisfies the agency's two
funding criteria — scientific merit and broader
impacts — as well as a clearer description for the
public of what the researcher hopes to accomplish.
Sixteen
of the twenty EHSCCs
funded by the National Institute
of Environmental Health Sciences (NIEHS) joined the working group to review the literature on the potential
public health
impact of UNGDO and to make recommendations for research.
«This is high and does not include the many other important ways that
public funding could
impact medical innovation — for instance by supporting the training
of graduate students and postdocs who end up bringing their skills to industry.»
Through the involvement
of Barfoot and Blackburn, the European Commission -
funded EuroStemCell project, which aims to educate the
public on stem cells and their
impact on society, has collaborated with Regenerative Medicine toward the publication
of these issues.
The Working Group generates estimates
of R&D investment that can be compared year to year across options and strategies and
funding sources, helping assess the
impact of public policies aimed at accelerating scientific progress and to provide facts for advocacy.
I find evidence that state
funding of universal kindergarten lowered high - school dropout and institutionalization rates among whites, but not among African Americans, and detect no
impact of state
funding for children
of either race on grade retention,
public assistance receipt, employment or earnings.
It yields a lower bound, understating the potential
impact of portability on federal
funding for
public schools, and showing how portability would matter even in areas with little private school presence.
Tom Payzant, the veteran superintendent who heads up Boston
Public Schools, says large school districts get
funding from a variety
of philanthropic organizations, but he has had to work hard to persuade these
funders to align their efforts to support a system - wide vision
of how to improve education and avoid contributing to what he calls «project-itis,» which is just a series
of ad hoc donations that make givers feel good but have little
impact on students.
By using the threat
of effectively denying the children
of military personnel access to
public education, the bill seeks to force the federal government either to increase its
impact - aid payments to districts or to establish separate schools, with full federal
funding, on the bases.
In her article, she looks at research on the
impact of the Kalamazoo Promise experiment, in which students attending
public schools in Kalamazoo, Michigan can access
funds from private donors to pay for all or most
of the tuition at any
of Michigan's
public universities or community colleges.
Some
of the legislators who voted against the bill expressed uncertainty about the
impact it would have on the
public school system and the state's general
fund.
While this report welcomed «the impressive progress made by the Programme
of sponsored academies to date» it expressed the worry that «academies» educational achievements should not be undermined by poor stewardship
of the
public funds necessary to sustain the
impacts of the Programme» and that there are «increased risks to value for money and proper use
of public money».
Most academies and local authority maintained schools are
impacted by the apprenticeship levy and
public sector apprenticeship target, but many are unclear
of how to access apprenticeship levy
funds available to them.
Although the absolute amount
of philanthropic investment in education ($ 1.8 billion in 2012) is significant, this
funding represents less than 1 %
of total
public K - 12
funding, raising questions about the level
of impact philanthropy can have at a systemic level.
Other recent work includes developing a school
funding model to simulate the
impact of student - based budgeting at the state level, evaluating a rural school grant, and providing strategic and research support for a nonprofit working to build the supply
of great
public schools in a Western state.
This paper, co-authored by Safal Partners and
Public Impact for the National Charter School Resource Center, examines practices used by some charter schools to engage EL families during recruitment, communicate with EL families with limited English proficiency, and meet the special needs
of enrolled EL students and their families, and also highlights the
funding mechanisms that support these strategies.
In «The Common Core Takes Hold,» Robert Rothman
of the Alliance for Excellent Education acknowledges a number
of McShane's concerns: states» shrinking budgets will likely
impact the
funding necessary for implementation; there is little to no quality monitoring
of the new resources that are being created; the new assessments — and the technology required to implement them — are hugely expensive; the
public at large is poorly informed and their support for the standards is waning; and a significant drop in student test scores following implementation
of Common Core - aligned assessments is a real concern.
The
impacts of the first private school voucher programs in the South still reverberate today in battles for adequate and equitable
funding of public education.
To coordinate our efforts and maximize the potential
impact of these
funds, TCSA has partnered with USEED to create a campaign in support
of public charter schools affected by Hurricane Harvey.
Bryan Hassel, co-director
of Public Impact, said he expects most
of the cost to be covered by grants the school system is pursuing or through professional development
funding from the state.
Each voucher is worth $ 12,000, resulting in an expected
impact of around $ 5 million, which is paid for using a reduction in state
funding sent to
public school districts.
«As
public schools nationwide struggle for
funding, complicated by the
impact of poverty and politics, corporate reformers see opportunity to take away local controls
of our community schools,» said Lyn Hoyt, president
of Tennesseans Reclaiming Education Excellence (TREE).
Any direct or indirect erosion
of Impact Aid through a voucher program will reduce the
Impact Aid
funding currently going to these districts, and would also place a great financial burden on the local community, which would be left to
fund public schools with an already low level
of state and local tax revenue.
The Wake County
Public School System provides 2 - to - 1 matching
of private
funds invested in our SummerSTEM program to maximize
impact.
As we document in
Public Impact's new report for the Charter School Growth Fund, Growing a High - Quality Charter Sector: Lessons from Tennessee, the state benefitted from the convergence of favorable policy conditions, political leadership, public - private grants, and an existing supply of local high - quality charter oper
Public Impact's new report for the Charter School Growth
Fund, Growing a High - Quality Charter Sector: Lessons from Tennessee, the state benefitted from the convergence
of favorable policy conditions, political leadership,
public - private grants, and an existing supply of local high - quality charter oper
public - private grants, and an existing supply
of local high - quality charter operators.