Sentences with phrase «impact on autophagy»

Not exact matches

Because the impact of autophagy on cancer seems to go both ways, cancer trials have tested therapies that enhance autophagy as well as drugs that block it.

«The decrease in physical activity indicates that autophagy in one organ can have a major impact on other organs, in this case probably muscle or motor neurons,» said Hansen.

While autophagy blockade is believed to render tumors more sensitive to chemotherapy, its impact on anti-tumor immunity is not well understood.

The researchers are now planning to address the impact of targeting autophagy either clinically and pharmacologically on the immune landscape of melanomas by phenotyping other immune cells in the melanoma tumor microenvironment.

«We wanted to ask how age impacts autophagy — is it at the beginning of the process by increasing the rate at which APs are formed, or, by analogy, how many garbage trucks are rolling out on the street — or is it at the end of the process by blocking the conversion of APs to ALs, i.e., how much recycling is taking place at the recycling plant.

We will study how signaling mechanisms impact homeostasis in cell - free, cell - based, and organismal systems, with a particular focus on the highly topical role of autophagy in different processes and studying autophagic mechanisms in depth.