Sentences with phrase «impact on gene»

At the same time, if screening reveals that there is little or no impact on gene expression from a particular chemical, why not pursue that one for commercial development?»

And while the long - term effects of GMO products are not really known, there are studies that show that GMO anti-nutrients can be destructive to health and have a negative impact on gene expression.

All of that information has a potential impact on the gene - expression profile.

- regulatory variants dysregulating microRNA transcriptional regulation with downstream impact on the gene regulatory programs in cancer.

We plan to develop new methods and tools for (1) improving the prediction of TFBSs; (2) predicting TF gene targets; (3) prioritizing cis - regulatory variants dysregulating microRNA transcriptional regulation with downstream impact on the gene regulatory programs in cancer.

BET proteins can have a huge impact on gene activity because they belong to a class of molecules called epigenetic readers, which recognize special marks on DNA - protein complexes and attract gene - activating proteins to those spots.

Mitchell and her colleagues eliminated this possibility when they deleted these nearby regions in the genome of mice and found there was no impact on the gene's ability to be turned on in embryonic stem cells.

«We found that simple changes have a powerful impact on gene expression,» Dean Ornish, founder and president of the Preventive Medicine Research Institute and clinical professor at the University of California, San Francisco (U.C.S.F.), said during a news conference.

Indeed, in some cases, contrary to what was expected, DNA methylation has no impact on gene expression.

«It was a little eerie and a little scary to see how something as subtle as a nutritional change in the pregnant mother rat could have such a dramatic impact on the gene expression of the baby,» Jirtle says.

RNAs contained in this non-coding part act as regulatory molecules and have a large impact on gene expression: where in the body and when during development or adulthood genes are expressed.

Turmeric not only tackles the environmental cause of man boobs by blocking the effects of estrogen on a cellular level, and helping to boost testosterone, but it also has a big impact on your genes.

Acrylamide has neurotoxic properties, and it may have a negative impact on genes and reproductive health.

Not exact matches

The launch of bitcoin futures could «have a material negative impact on the price of bitcoin,» says Gene Munster of Loup Ventures.

'' «At PMV Pharmaceuticals, we are targeting the most frequently mutated gene in human cancer (p53) to make an unprecedented impact on cancer patients» lives.

«The event, the fourth of its kind, seeks to raise global awareness and create a forum for collaboration around the wide array of powerful and promising cell therapies, gene therapies, and immunotherapies emerging from medical institutions around the world, as well as the impact new technology will have on humanity and society,» a press release by the Cure Foundation explains (h / t Christian Post).

In fact, specific genes are studied for their impact on the threshold effect of some teratogens.

Entitled Social science and epigenetics: opportunities and challenges, the symposium will seek to examine how multidisciplinary research into epigenetics — the science of the lasting marks that modify the expression of the genes encoded in our DNA — might help provide answers to societal concerns including why deprivation has such a marked impact on child development and on health outcomes.

The study, led by Dr Len Stephens and Dr Phill Hawkins and published today in the journal Molecular Cell, reveals why loss of the PTEN gene has such an impact on many people with prostate cancer, as well as in some breast cancers.

That's in contrast to the impact of a gene on chromosome 20 that increased protein concentration but also significantly decreased yields in soybean varieties.

Others have found that boys are more vulnerable than girls to the long - term impact of maltreatment in childhood, and the risk of such boys becoming antisocial in later life seems to be related to a gene on the X chromosome, although not one that is imprinted.

The aim of the study is to understand the impact of environmental factors, lifestyle factors and genes on health.

«But there hasn't been research conducted on how this gene impacts agronomic traits, like yield,» says Diers.

Dr Antonio Pardiñas, first author of the study, said: «We show for the first time that genetic variants that do not severely impact gene function, but presumably have a more subtle impact on these critical genes, increase risk for developing schizophrenia.»

The study was designed by Robert Plomin of the Institute of Psychiatry at King's College London and his colleagues, to tease apart the impact of genes and the environment on educational achievement.

The researchers focused on a gene located on chromosome 15, which was previously shown to impact protein concentration.

A controversial study on twins claims to provide evidence that the genes we inherit have a bigger impact on exam success than schooling and parenting.

But Greg Aharorian, director of the Centre for Global Innovation / Patent Metrics, believes the dispute won't have any serious impact on science and R&D, though he warns the longer the patent battle continues without a deal the greater the chance new types of gene editing will be discovered, which will «potentially undercut their future profits».

«From other studies ***** we know that epigenetic modifications of the DPP4 gene, which are associated with an increased production of the enzyme, have a negative impact on the liver metabolism already in young mice, long before fatty liver disease emerges,» says Baumeier.

As millions of tons of fishmeal are used every year with much of it sinking uneaten to the ocean floor, Jing Wang and colleagues wanted to see what its impact could be on the mariculture «resistome,» or collection of resistance genes.

One of many researchers lending support to the cause is genome scientist and Nobelist John Sulston of the University of Manchester, U.K., who warns that «gene patents can have a chilling impact on research, obstruct the development of new genetic tests, and interfere with medical care.»

«A study covering a large number of subjects, like the one in 2015, makes it possible to identify the relevant genes across the entire population; but their variations have only a limited impact on individuals.

The brain - size - altering effect of the gene is what led the researchers to study the impact on IQ.

A study led by researchers at Boston University School of Medicine (BUSM) provides novel insight into the impact that genes may have on Huntington's disease (HD).

Mitochondrial DNA carries far fewer genes than DNA in the nucleus does, but changes in mitochondrial DNA sequence can have a major impact on health.

But many genes could have a moderate impact on whether a person gets diabetes, and many others could have a minor impact.

Analysis of the tumor genes affected by the two drugs revealed that cabazitaxel had a greater effect on cellular division and regulation of chromatin — a spool for DNA that helps control which genes are in use and when — whereas docetaxel has a greater impact on DNA transcription and repair.

But it remains unclear what the exact impact of including this double copy of the gene will be on a broader scale.

«There are a range of metabolic diseases and other liver disorders where if you fix a mutated gene you might be really able to have an impact on human health,» Anderson says.

The study is the first to look at these different biological markers, as well has how the gene's impact on dopamine production specifically affects Caucasian populations.

Scientists earlier described compounds that can boost ethA activity, making the drug more potent, but these have no impact on M. tuberculosis strains that have mutations in the gene and are completely resistant to the ethionamide.

The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait loci (eQTLs), which link polymorphisms in single genes to quantifiable changes in gene expression associated with specific diseases.

«Finally, we analyzed four mutants in the study and we proved the impact on the seed longevity when the overexpression of the ATHB25 gene is introduced,» states Ramón Serrano, researcher at the IBMCP.

One speculation from Wigler is that mutations with very damaging impact on cognition will tend to be eliminated rapidly from the gene pool, as people with them are less likely to have children.

The researchers also investigated the impact of aneuploidy on other biological pathways, such as transcription, the first stage of gene expression in which a segment of DNA is copied into RNA.

The more risk genes an individual has, the more negative an impact the «life events» have on the size of the hippocampus.

Co-author Christina Hvilsom, a researcher at Copenhagen Zoo, said, «We have learned from the comparable studies of modern humans and Neanderthals that gene flow occasionally has an impact on parts of the genomes that provide some advantages for the admixed individuals.

They also say they are concerned about the antibiotic resistance marker gene that the wheat contains, and assert that the researchers «are openly releasing a synthetic version of a compound that... has had no long - term health safety tests whatsoever for human consumption, or for its impacts on non-target species.»

This finding matters because — by impacting on who mixes their genes with whom — choosiness is a key factor shaping the biodiversity of species.

Although gene variations are primarily inherited at conception, the findings show that environmental impacts can also introduce them later on.