Sentences with phrase «impact with lower levels»

• Generation X lawyers felt their work had less social impact with lower levels of work - life balance and exhibited less overall satisfaction.

Not exact matches

While top - down channels are used to communicate vision and strategy in order to get policies and processes aligned with them, bottom - up processes are necessary too, in order for leaders to be aware of the issues faced at the lower levels, as well as to measure the impact of the policies and practices implemented.

Actual results, including with respect to our targets and prospects, could differ materially due to a number of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Risks associated with the Consumer Discretionary sector include, among others, apparel price deflation due to low - cost entries, high inventory levels and pressure from e-commerce players; reduction in traditional advertising dollars; increasing household debt levels that could limit consumer appetite for discretionary purchases; declining consumer acceptance of new product introductions; and geopolitical uncertainty that could impact consumer sentiment.

Companies with low levels of automation must identify, streamline and automate high - impact business processes.

As the result from the study shows the glucose levels might increase if having caffeine together with a meal with a high amount of carbohydrates but there is no indication what the impact is for people who eat according to a low carb diet.

For brand owners who want consistent drop - impact toughness in their dual ovenable trays, Elvaloy ® resins are premium compatibilizers that, when combined with Elvaloy ® AC or similar resins, provide the desired level of low - temperature PET toughness in refrigerated and frozen meals.

Whilst a lot of the media discussion from Week 4 of the Premier League has revolved around boring games, the low level of goals scored so far, and even the amount of time that the ball is actually in play, it's actually been a very busy weekend for the Manager Impact Index with Villas Boas, David Moyes and Michael Laudrup being the stand out performers this week.

«Even with very low levels, these chemicals can have a major impact on a child's body because they are rapidly developing and weigh so little,» which means their bodies are generally less capable of eliminating toxins.

Much of frontline policing is taken up with low level anti-social behaviour, which has a big impact on the quality of life of Londoners, but is not always best dealt with by the Met.

Gillibrand said Sunday that she sent a letter to Sessions inviting him to talk about the impacts the War on Drugs has had on New York's black and Latino communities with constituents who are denied jobs, housing and college financial aid because of nonviolent, low - level pot arrests.

The changes came after labor unions raised issues with the initial version of the amendment, which they said was far too broad in its scope and could impact lower level civil servants.

If you're going to criticize the educational level of minorities, I'm wondering why other groups get high level policy positions that impact on the lives of most Americans with low levels of education.

«This Agreement, in enhancing the implementation of the [2015 United Nations Framework Convention on Climate Change], including its objective, aims to strengthen the global response to the threat of climate change, in the context of sustainable development and efforts to eradicate poverty, including by: (a) Holding the increase in the global average temperature to well below 2 °C above pre-industrial levels and pursuing efforts to limit the temperature increase to 1.5 °C above pre-industrial levels, recognizing that this would significantly reduce the risks and impacts of climate change; (b) Increasing the ability to adapt to the adverse impacts of climate change and foster climate resilience and low greenhouse gas emissions development, in a manner that does not threaten food production; and (c) Making finance flows consistent with a pathway towards low greenhouse gas emissions and climate - resilient development.

The positive impact of sustained high levels of maternal responsivity from toddlerhood through middle childhood was true even for children with more autistic symptoms and lower nonverbal cognitive development levels.

The median funding level for PIs publishing in journals with lower impact factors — such as PLOS ONE and the Journal of Biological Chemistry — was not much lower, about the 70th percentile, but the distribution of funding brackets was more diverse.

«Female athletes with exercise - induced menstrual dysfunction (associated with low estrogen levels) often have disordered eating behavior, which may impact their reproductive and bone health,» said lead researcher Madhusmita Misra, M.D., M.P.H., professor of pediatrics at Harvard Medical School and a pediatric endocrinologist at Massachusetts General Hospital in Boston, Mass..

«The Dam Impact Analysis Model provides managers with a way to assess the levels of survival needed for Atlantic salmon at several large mainstem dams in the lower Penobscot River,» said Jeff Murphy, an endangered species biologist at GARFO.

Raising HDL levels with niacin does not appear to impact cardiovascular outcomes nor does lowering triglyceride levels, Lloyd - Jones points out.

According to Joseph P. Gill, Secretary of the Maryland Department of Natural Resources, impacts associated with sea level rise are already being seen along Maryland's coast, such as the documented loss of islands within the Chesapeake Bay, as well as visible changes to wetland habitats all along Maryland's low - lying eastern shore.

Large CDC study shows rocket compound in water impacts women with low levels of iodine; concern for pregnant women

Red arrows indicate higher or lower levels or impact in women compared with men.

We also present evidence that TRLs with reduced ApoC - III content do not affect lipolysis and that a reduction in LPL expression and activity does not suppress the impact of ASO inhibition on lowering plasma TG levels.

This means that low cholesterol is not in itself a measure of success when treating disease, but it can have a greater impact when paired with reduced sugar levels.

Not only is Spinning low impact and so good for people who have a hard time with high - impact exercises, but it is also great for people of all fitness levels.

While low impact exercise aids cardiovascular fitness and fat loss to some extent, you won't see huge increases in your fitness levels, strength or body composition with these alone.The reason?

While low impact exercise aids cardiovascular fitness and fat loss to some extent, you won't see huge increases in your fitness levels, strength or body composition with these alone.

Compared with protein or carbohydrates, fat has the lowest impact on insulin levels.

While low testosterone levels do indeed have a great number of undesirable physical side effects — increased body fat, less energy, low libido all among them — low levels can also carry with them a tremendous psychological impact.

I didn't want to move straight into traditional prenatal yoga classes, and I assumed that since yoga is so low - impact and modifiable for different levels of fitness, I wouldn't need to change too much to keep up with my regular classes.

A study of Asian vegetarians with incomplete amino acid intake showed reduced clearing of xenobiotics.47 Low levels of hydrochloric acid have an adverse impact on the availability of dietary amino acids, even in a higher protein diet, so stimulating the pancreas using lacto - fermented foods is crucial.

Testosterone production in men naturally reduces with age, but low levels of this hormone can sap your energy levels, weaken your sex drive and negatively impact your health.

When stress (mental / emotional, physical or biochemical stress can all impact this) is suppressing the pituitary gland enough to interfere with producing TSH, you might see low or normal TSH levels in the presence of low thyroid hormone production (T3 or T4), and hypothyroid symptoms.

Considering these data together with those of MacNeil, it's likely that potato starch doesn't impact blood glucose levels because digestion of the digestible portion occurs at such a low rate that glucose absorption is easily matched by glucose clearance.

You see with lower hormone levels we are more prone to problems such as osteoporosis, depression, anxiety, loss of collagen, heart attacks and a big one for me is the negative impact on brain health.

While a Soy level of only 0.01 mg is too low for nutritional warning labels, and it might have no impact for many individuals with Soy allergies, we believe it is still better for all to know how much Soy is in PrimalKind.

For those with a high level of excess bodyweight, low - impact exercises such as swimming are an excellent way to partake in cardiovascular exercise and burn fat, whilst exerting minimal impact stress to the muscles and joints.

Glycemic index, glycemic load, and chronic disease risk — a meta - analysis of observational studies) concluded that using the glycemic index (GI scale that rates a food's ability to impact blood glucose levels) to consume lower GI foods is associated with lower triglycerides and higher good HDL cholesterol lipid profiles.

All of this along with others is intentional to get cancer under control, reduce inflammation, increase GSH levels through gluthathione (which is one of the greatest impact to automimmune, low levels) In less than 2 months: no pain in joints yet I have bone cancer secondary to metastatic breast cancer, all swelling out of the body, my lymphatic, adrenal, stomach, colon, liver all greatly impacted by chemo (the red devil) 4 years ago.

If most of what's on your plate is vegetables or other foods with a low GI, then the overall meal itself will probably have a moderate impact on your glucose levels.

Researchers have found that BDNF levels decline progressively with age.10 Lommatzsch, M., et al. «The Impact of Age, Weight and Gender on BDNF Levels in Human Platelets and Plasma,» Neurobiology of Aging 26 (2005):... continue At the same time that BDNF levels decrease, the volume of the hippocampus (primary center for emotion and memory) also decreases.11 Erickson, K.L., et al. «Brain - Derived Neurotrophic Factor is Associated with Age - Related Decline in Hippocampal Volume, Journal of Neuroscience 30,... continue In fact, in some neurological diseases, such as Huntington's and Alzheimer's disease, BDNF levels are low or deficient.12 Laske, C., et al. «Decreased Brain - Derived Neurotrophic Factor (BDNF) and B - Thromboglobulin Blood Levels in Alzheimer's Disease,» Journal of... colevels decline progressively with age.10 Lommatzsch, M., et al. «The Impact of Age, Weight and Gender on BDNF Levels in Human Platelets and Plasma,» Neurobiology of Aging 26 (2005):... continue At the same time that BDNF levels decrease, the volume of the hippocampus (primary center for emotion and memory) also decreases.11 Erickson, K.L., et al. «Brain - Derived Neurotrophic Factor is Associated with Age - Related Decline in Hippocampal Volume, Journal of Neuroscience 30,... continue In fact, in some neurological diseases, such as Huntington's and Alzheimer's disease, BDNF levels are low or deficient.12 Laske, C., et al. «Decreased Brain - Derived Neurotrophic Factor (BDNF) and B - Thromboglobulin Blood Levels in Alzheimer's Disease,» Journal of... coLevels in Human Platelets and Plasma,» Neurobiology of Aging 26 (2005):... continue At the same time that BDNF levels decrease, the volume of the hippocampus (primary center for emotion and memory) also decreases.11 Erickson, K.L., et al. «Brain - Derived Neurotrophic Factor is Associated with Age - Related Decline in Hippocampal Volume, Journal of Neuroscience 30,... continue In fact, in some neurological diseases, such as Huntington's and Alzheimer's disease, BDNF levels are low or deficient.12 Laske, C., et al. «Decreased Brain - Derived Neurotrophic Factor (BDNF) and B - Thromboglobulin Blood Levels in Alzheimer's Disease,» Journal of... colevels decrease, the volume of the hippocampus (primary center for emotion and memory) also decreases.11 Erickson, K.L., et al. «Brain - Derived Neurotrophic Factor is Associated with Age - Related Decline in Hippocampal Volume, Journal of Neuroscience 30,... continue In fact, in some neurological diseases, such as Huntington's and Alzheimer's disease, BDNF levels are low or deficient.12 Laske, C., et al. «Decreased Brain - Derived Neurotrophic Factor (BDNF) and B - Thromboglobulin Blood Levels in Alzheimer's Disease,» Journal of... colevels are low or deficient.12 Laske, C., et al. «Decreased Brain - Derived Neurotrophic Factor (BDNF) and B - Thromboglobulin Blood Levels in Alzheimer's Disease,» Journal of... coLevels in Alzheimer's Disease,» Journal of... continue

Noting the low level of evidence security, it is calculated that using learning styles within the classroom (for example, to match teaching style to learning style) has a low impact with an effect size of 0.13 or two months» worth of learning progress.

Any direct or indirect erosion of Impact Aid through a voucher program will reduce the Impact Aid funding currently going to these districts, and would also place a great financial burden on the local community, which would be left to fund public schools with an already low level of state and local tax revenue.

She also found that math anxiety has an impact on those with high, rather than low amounts of working memory — the very students who have the potential to take mathematics to higher levels.

But they worry about the impact on low - income students who are more likely to read below grade level and struggle with the fundamentals of literary analysis (much less making connections across multiple and challenging texts).

The dreaded «summer slide» in learning impacts all students, with low - income students feeling the biggest hit — losing 2.5 to 3 months of grade level equivalency over the summer months.

The study assumed a low level of familiarity on the part of the participants with the presented technologies and measured the impact of participants» exposure to the technologies across a 5 - week period.

Low levels of educational attainment have a direct impact upon socio - economic conditions, with 2006 data demonstrating that the median income for Indigenous peoples ($ 18,962) was 30 % lower than that of non-Indigenous Canadians ($ 27» 097)[1].

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