Sentences with phrase «impacted by the cycle»

Not exact matches

Cloud computing, the buzzword sweeping the tech world, claimed the top spot in the most recent Hype Cycle report put out by Gartner Research, while a BusinessWeek cover story compared the technology's impact to the introduction of electricity.

In its press release, Tableau chairman and co-founder Christian Chabot said the company's results were «impacted by extended sales cycles on large deals in the U.S. and softness in (international markets).»

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

That is exactly what happened, the lenders exhausted the pool of borrowers, the reflexive impact of rising demand pushing prices higher began to wane, and the virtuous cycle turned dramatically (as they always do eventually) into a vicious cycle that triggered the Global Financial Crisis and those same banks that made all the ill - advised loans were crushed by massive losses Then, yet again, what were the «Masses» doing at the peak?

Many factors could cause BlackBerry's actual results, performance or achievements to differ materially from those expressed or implied by the forward - looking statements, including, without limitation: BlackBerry's ability to enhance its current products and services, or develop new products and services in a timely manner or at competitive prices, including risks related to new product introductions; risks related to BlackBerry's ability to mitigate the impact of the anticipated decline in BlackBerry's infrastructure access fees on its consolidated revenue by developing an integrated services and software offering; intense competition, rapid change and significant strategic alliances within BlackBerry's industry; BlackBerry's reliance on carrier partners and distributors; risks associated with BlackBerry's foreign operations, including risks related to recent political and economic developments in Venezuela and the impact of foreign currency restrictions; risks relating to network disruptions and other business interruptions, including costs, potential liabilities, lost revenues and reputational damage associated with service interruptions; risks related to BlackBerry's ability to implement and to realize the anticipated benefits of its CORE program; BlackBerry's ability to maintain or increase its cash balance; security risks; BlackBerry's ability to attract and retain key personnel; risks related to intellectual property rights; BlackBerry's ability to expand and manage BlackBerry ® World ™; risks related to the collection, storage, transmission, use and disclosure of confidential and personal information; BlackBerry's ability to manage inventory and asset risk; BlackBerry's reliance on suppliers of functional components for its products and risks relating to its supply chain; BlackBerry's ability to obtain rights to use software or components supplied by third parties; BlackBerry's ability to successfully maintain and enhance its brand; risks related to government regulations, including regulations relating to encryption technology; BlackBerry's ability to continue to adapt to recent board and management changes and headcount reductions; reliance on strategic alliances with third - party network infrastructure developers, software platform vendors and service platform vendors; BlackBerry's reliance on third - party manufacturers; potential defects and vulnerabilities in BlackBerry's products; risks related to litigation, including litigation claims arising from BlackBerry's practice of providing forward - looking guidance; potential charges relating to the impairment of intangible assets recorded on BlackBerry's balance sheet; risks as a result of actions of activist shareholders; government regulation of wireless spectrum and radio frequencies; risks related to economic and geopolitical conditions; risks associated with acquisitions; foreign exchange risks; and difficulties in forecasting BlackBerry's financial results given the rapid technological changes, evolving industry standards, intense competition and short product life cycles that characterize the wireless communications industry.

Supply of limited resources is being further constrained by more severe and unpredictable climate events and more potent microbes, pests and diseases — causing food producers to more seriously consider the environmental life cycle impact of food production activities.

* Based on streamlined life cycle assessment (LCA) by Environmental Packaging International on various packaging options, using a web - based Packaging Impact Quick Evaluation Tool (PIQET).

Again, the consistency of your cycle and symptoms related to your period will be impacted by how frequently your baby is nursing and how that affects your hormones.

They fought over whether governments should intervene in markets; both were influenced by the impact of WW1 and had studied the boom and bust of the business cycle.

«When you have voters who have been betrayed by their elected officials on an issue as important as marriage, the impact on the election cycle is a big one.»

He explained that compilation of the report had suffered some setbacks occasioned by the non-disbursement of approved funding from development partners, and more particularly by the impact of the electoral cycle on the country's fiscal space

This research in Transport aims to study the impact of cycle lanes on cyclist safety in terms of passing space given by overtaking vehicles.

However, it is electricity consumption by microwave appliances that has the biggest impact on the environment, taking into account its whole life cycle, from production of fuels to generation of electricity.

In the meantime, I hope my thesis work will address some equally interesting questions: how migration of barren - ground caribou impacts wolf movement, whether there is such a thing as the arctic wolf (currently listed «data deficient» by the Committee for the Status of Endangered Wildlife in Canada), whether arctic foxes migrate or just disperse, and how lemming cycles affect that decision.

These maps, with more than 50,000 pixels, show surprisingly large local variation in trait values that could significantly impact future carbon cycle calculations produced by Earth System models (ESMs).

Unseen by the human eye, plants interact with many species of fungi and other microbes in the surrounding environment, and these exchanges can impact the plant's health and tolerance to stressors such as drought or disease, as well as the global carbon cycle.

Environmental economists try to calculate the environmental impacts from making products by using tools called life - cycle assessments or «multi-regional input - output» models, abbreviated MRIO.

Their results showed that changes in key water - stress variables are strongly modified by vegetation physiological effects in response to increased CO2 at the leaf level, illustrating how deeply the physiological effects due to increasing atmospheric CO2 impact the water cycle.

One limitation to all studies that aim to quantify the environmental impacts of human diets is that many of the life - cycle analyses used by researchers are conducted in other countries.

The study, commissioned by CHEOPS - a perovskite research project co-funded by the European research and innovation programme Horizon 2020, is being conducted by SmartGreenScans, a CHEOPS member, specialising in Life - Cycle Assessments (LCA) of photovoltaic technologies, to assess the life - cycle environmental impact of the perovskite - on - silicon tandem cells being commercialised by OxforCycle Assessments (LCA) of photovoltaic technologies, to assess the life - cycle environmental impact of the perovskite - on - silicon tandem cells being commercialised by Oxforcycle environmental impact of the perovskite - on - silicon tandem cells being commercialised by Oxford PV.

The global science community still isn't entirely sure what caused the repeated cycles — there may have been larger oceans in the northern hemisphere that powered a hydrological cycle (evaporation, condensation, precipitation), or shorter cycles could've been caused by volcanic activity or asteroid / comet impacts.

The impact on climate when thinking «by 2100» depends not only on the sensitivity, but also on socio - economic pathways and carbon cycle uncertainties, which determine what the CO2 concentration will be.

About BIOACID: Since 2009, more than 250 BIOACID scientists from 20 German research institutes have investigated how different marine organisms respond to ocean acidification and increasing carbon dioxide concentrations in seawater, how their performance is affected during their various life stages, how these reactions impact marine food webs and elemental cycles and whether they can be mitigated by evolutionary adaptation.

Whether you want to understand your mood swings, determine whether your headaches are driven by hormones, or learn how your cycle impacts your sleep throughout the month, Ava can help.

Despite these factors (which may not actually be true), nearly every strength coach can impact their athletes» overall muscle development, athletic performance, and injury resilience by using the below bodybuilding guidelines at some point in a training cycle.

To summarize: 1) Low intensity, moderate duration cycling has a negligible impact on strength, and can easily be incorporated by most strength athletes with minimal effect.

Pros and Cons of Specialty Bars for Dynamic Waves discussing the impact of varying the the implement (the barbell) throughout different weekly cycles, bottom - line make sure you won't get confused by too much variation if you can't measure and monitor your workload.

Walking and cycling are both low impact exercises which can be enjoyed by all.

12.4 by 2020 achieve environmentally sound management of chemicals and all wastes throughout their life cycle in accordance with agreed international frameworks and significantly reduce their release to air, water and soil to minimize their adverse impacts on human health and the environment

Another issue which could impact on the timely supply of information to HMRC is the monthly pay cycle operated by the payroll provider.

Discovery Sport is designed with a life cycle approach, aiming to minimise environmental impact by considering the entire life cycle of the vehicle.

Over the same tightening cycle that ended in 2006, the impact on the 10 - Year U.S. Treasury Bond yield was 60 bps higher, driving the 1 - Year / 10 - Year slope to flatten by 265 bps (see Exhibit 1).

Despite a typical hiking cycle causing a flattening of the yield curve, we are potentially embarking on a path where yield curves may steepen significantly, as the Fed may be concluding that financial conditions (i.e. stock prices) can only be impacted by engineering a steeper yield curve and higher term premium.

In addition, Microsoft has faced challenges and its earnings are impacted by the slower upgrade cycle and substitute demand for tablets.

It has been historically agreed by many economists, that the US elections have an impact on stock market and the election cycles correlate with the market returns.

After the second heat cycle, there is no significant impact on her risk by spaying.

The video below details how the world is impacted by a «dynamic» day and night cycle as well as a offering a closer look into their new system to capture light realistically, advanced volumetric lighting, procedural destruction and impressive particle effects resulting in some pretty stunning looking graphics to excite those of us who have taken a leap to the next - gen systems and maybe entice those still stuck on the fence.

Inspired by the special exhibition Jasper Johns and Edvard Munch: Love, Loss, and the Cycle of Life, this gallery talk contemplates three works by Ernst Ludwig Kirchner (1880 — 1938), part of the Ludwig and Rosy Fischer Collection, a key German Expressionist artist with consideration of the impact of his life experiences.

The probability calculation Almuth proposes is tailor made for influencing the public towards «greater» action, while a calculation that looked at say the impact of Kyoto in 2020 on the wind speed of a second Katrina, compared that to the variability introduced by natural cycles and emphasised that this was based on models, while there had been no conclusive trend in tropical cyclone wind speeds so far, would be made with a different kind of advocacy in mind (Pielke et al's paper is very clearly going in this direction).

We show that, although drones consume less energy per package - km than delivery trucks, the additional warehouse energy required and the longer distances traveled by drones per package greatly increase the life - cycle impacts.

And if the impacts are becoming greater, that does raise the point that such bigger impacts will also be felt by the carbon cycle.

Between 75 and 80 percent of our clothing's lifecycle impact comes from washing and drying, according to reports by Proctor (pdf) and Marks & Spencer, because it takes so much energy to heat the wash water and run the dry cycle.

If the Jakobshavn effect is the key the velocity will propagate up - glacier, the terminus velocity will be impacted by tides, and there will be no seasonal cycle.

Global warming is one kind of climate change caused by an increased greenhouse effect with an impact on both meteorology and the hydrological cycle.

From what data exists about previous peroids of rapid climate change (i.e. climate change caused by an intrinsic mechanism such as a meteor impact, massive volcanic activity or human activity, as opposed to sun cycles), it seems that climate does show such behavior too.

Three years earlier, in 2006, Exxon also reversed the direction of the pipeline's flow, a move that would automatically alter the impact of pressure cycles by changing where the highest and lowest pressures hit along the pipeline.

Finally I attempt a suggestion that perhaps one solution to the problem that the solar impact on climate is underestimated by models might be because EBM and GCM, like GISS, do not contain CO2 and CH4 cycle mechanisms that might be partially effected by the Sun, and other mechanisms are missing or uncertain (water vapor, cloud cover, vegetation, bacteria respiration, UV radiation, cosmic ray effects etc.).

We recently commissioned a report, Life Cycle Assessment of alternatively fuelled vehicle (available from www.travelfootprint.org) which showed that electric vehicles that are charged by renewable energy have the lowest environmental impact.

In essence Tung & Zhou are dining at the denialist's last - chance saloon by invoking a 60 - year natural cycle (their cycle of choice being AMO) resulting in a reduced anthropogenic influence on climate, although they make sure to not directly challenge climate sensitivity by asserting that their findings will impact on assessment of net anthropogenic forcing and leave climate sensitivity estimates unchallenged.

At the sovereign nation level monitoring should encompass the internal disparities of the unfair impacts of climate change on the poor who by far have the smallest carbon footprint but will come to bear the brunt of harsh climate change impacts from vicious weather cycles to survival access to drinking water, food and shelter.